Lanreotide
Also known as Ipstyl, Lanreotida, Lanreotidum
Key facts
What buyers check first
- CAS number
- 108736-35-2
- Formula
- C54H69N11O10S2
- Molar mass
- 1,096.35 g/mol
- EC number
- 689-178-4
- HS code
- 293719
- Category
- Oncology and immunology drugs
What is Lanreotide?
Plain description, key identifiers and synonyms
Lanreotide is a synthetic cyclic octapeptide analogue of somatostatin. Lanreotide binds to somatostatin receptors (SSTR), specifically SSTR-2 and also to SSTR-5 with a lesser affinity. However, compare with octreotide, this agent is less potent in inhibiting the release of growth hormone from the pituitary gland. Furthermore, lanreotide has an acute effect on decreasing circulating total and free insulin-like growth factor 1 (IGF-I). This agent is usually given as a prolonged-release microparticle or Autogel formulation for the treatment of acromegaly and to relieve the symptoms of neuroendocrine tumors.
Lanreotide is a pharmaceutical drug.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- (4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-19-[[(2R)-2-amino-3-naphthalen-2-ylpropanoyl]amino]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
- CAS number
- 108736-35-2 CAS number cross-checkedOther or deprecated CAS: 118992-92-0
- EC number
- 689-178-4
- Molecular formula
- C54H69N11O10S2
- UNII
- 0G3DE8943Y
- MDL number
- MFCD03424071
- InChIKey
- PUDHBTGHUJUUFI-SCTWWAJVSA-N
- InChI
- InChI=1S/C54H69N11O10S2/c1-29(2)45-54(75)63-44(53(74)65-46(30(3)66)47(57)68)28-77-76-27-43(62-48(69)38(56)23-32-15-18-33-10-4-5-11-34(33)22-32)52(73)60-41(24-31-16-19-36(67)20-17-31)50(71)61-42(25-35-26-58-39-13-7-6-12-37(35)39)51(72)59-40(49(70)64-45)14-8-9-21-55/h4-7,10-13,15-20,22,26,29-30,38,40-46,58,66-67H,8-9,14,21,23-25,27-28,55-56H2,1-3H3,(H2,57,68)(H,59,72)(H,60,73)(H,61,71)(H,62,69)(H,63,75)(H,64,70)(H,65,74)/t30-,38-,40+,41+,42-,43+,44+,45+,46+/m1/s1
- Canonical SMILES
- CC(C)C1NC(=O)C(CCCCN)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(NC(=O)C(N)Cc2ccc3ccccc3c2)CSSCC(C(=O)NC(C(N)=O)C(C)O)NC1=O
- Isomeric SMILES
- C[C@H]([C@@H](C(=O)N)NC(=O)[C@@H]1CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)C(C)C)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)[C@@H](CC5=CC6=CC=CC=C6C=C5)N)O
Synonyms
- Ipstyl
- Lanreotida
- Lanreotidum
- Lanreotide Autogel
- BIM 23014
- DC 13-116
- Nal-cyclo(cys-tyr-trp-lys-val-cys)-thr-NH2
- Somatulina
- Somatuline LA
- L-Threoninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2-7)-disulfide
- BIM 23014C
- Dermopeptin
- DC 13116
- Nal-cyclo(Cys-Tyr-Trp-Lys-Val-Cys)Thr-NH2
- naphthyl-cyclo(Cys-Tyr-Trp-Lys-Val-Cys)Thr-NH2
- 2-naphthylalanyl-cyclo(cysteinyl-tyrosyl-tryptophyl-lysyl-valyl-cysteinyl)-threoninamide
- naphthalenyl-cyclo(cysteinyl-tyrosyl-tryptophyl-lysyl-valyl-cysteinyl)threoninamide
- L-Threoninamide, 3-(1-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2-7)-disulfide
- 3-(2-Naphthyl)-D-ala-cys-tyr-D-trp-lys-val-cys-thr-NH2
- 3-(2-Naphthyl)alanyl-cystinyl-tyrosyl-tryptophyl-lysyl-valyl-cystinyl-threonine amide
- D-Nal-cys-tyr-trp-lys-val-cys-thr-NH2
- Autogel
- Somatulin
- Somatulin-Autogel
- 188Re-lanreotide
Show all 31 synonymsShow fewer synonyms
- 108736-35-2 (free base)
- Lanreotide,Lanreotide Acetate
- L-Threoninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2-->7)-disulfide
- 108736-35-2ree base?Lanreotide Acetate
- 3-(2-Naphtyl)-D-Ala-L-Cys(1)-L-Tyr-D-Trp-L-Lys-L-Val-L-Cys(1)-L-Thr-NH2
- L-Threoninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2 inverted exclamation marku7)-disulfide
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 1,096.35 g/molcalc.Computed value |
|---|---|
| Exact mass | 1,095.467 Dacalc.Computed value |
| LogP (octanol/water) | 0.82calc.Computed value |
| Topological polar surface area | 355.1 ร
ยฒcalc.Computed value |
| Hydrogen bond donors | 13calc.Computed value |
| Hydrogen bond acceptors | 14calc.Computed value |
| Rotatable bonds | 17calc.Computed value |
| Heavy atoms | 77calc.Computed value |
| Rings | 6calc.Computed value |
| Aromatic rings | 5calc.Computed value |
| Fraction sp3 carbons | 0.41calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 9calc.Computed value |
| Lipinski rule of five | Fails (3 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
O=C1CNC(=O)CNC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCc2ccc3ccccc3c2)CSSCCN1
6 rings, 57 atoms.
13 other chemicals share this scaffoldSafety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H361Suspected of damaging fertility or the unborn child.
Precautionary statements (5)
- P203Obtain, read and follow all safety instructions before use.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
- P318If exposed or concerned, get medical advice.
- P405Store locked up.
- P501Dispose of contents and container in accordance with local regulations.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidLanreotide suppliers
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- ChinaUnclaimed profileLanreotideGrade, purity and minimum order on requestPrice on request
- China, HangzhouUnclaimed profileLanreotideGrade, purity and minimum order on requestPrice on request
- ChinaUnclaimed profileLanreotideGrade, purity and minimum order on requestPrice on request
- SpainUnclaimed profileLanreotideGrade, purity and minimum order on requestPrice on request
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- India, Navi Mumbai ManufacturerUnclaimed profileLanreotideGrade, purity and minimum order on requestPrice on request
- Spain, Sant Quinti De Mediona ManufacturerUnclaimed profileLanreotideGrade, purity and minimum order on requestPrice on request
- Greece, Pallini ManufacturerUnclaimed profileLanreotideGrade, purity and minimum order on requestPrice on request
- China, ShanghaiUnclaimed profileLanreotideGrade, purity and minimum order on requestPrice on request
- China ManufacturerUnclaimed profileLanreotideGrade, purity and minimum order on requestPrice on request
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Where suppliers are based
54 suppliers in 12 countries
- United States20
- China17
- Spain5
- United Kingdom3
- Germany2
- Greece1
- and 6 more countries
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Lanreotide price
Indicative price range per kg from live supplier offers
Suppliers quote this chemical on request. Send one free request and compare quotes side by side.
Uses and applications
What the substance is used for, by industry and function
Industries and functions
Pharmacological actions
- Antineoplastic Agents
Pharmacology
Lanreotide is a Somatostatin Analog. The mechanism of action of lanreotide is as a Somatostatin Receptor Agonist.
Regulatory status
Inventories, regulations and trade controls that list this substance
Health and food
- Active ingredient in FDA approved drug labels
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Lanreotide is traded under.
Polypeptide hormones, protein hormones and glycoprotein hormones, their derivatives andโฆ
- Ireland57.3%
- United States29.0%
- Denmark6.3%
- United States50.4%
- Italy28.1%
- Germany7.4%
The HS code shown for Lanreotide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Frequently asked questions
Quick answers about Lanreotide, based on the data on this page
What is Lanreotide?
What is the CAS number of Lanreotide?
What is the molecular formula and weight of Lanreotide?
What is Lanreotide used for?
Is Lanreotide hazardous?
What is the HS code of Lanreotide?
Where can I buy Lanreotide?
Where can I buy Lanreotide in India?
What is the price of Lanreotide?
Guides for buyers
Practical guides that help when you source, ship or handle Lanreotide
- Article, QualityPharma grades explained: IP vs BP vs USP vs EPWhat the Indian, British, US and European pharmacopoeias are, how their monographs differ, what multi grade claims mean and why a grade alone does not make a product fit for medicines.Read
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, SafetyGHS pictograms, signal words and hazard statements explainedA practical guide to the nine GHS pictograms, the signal words Danger and Warning, H and P statements, and how to read a chemical label in seconds.Read
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