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Screening compounds

Linifanib

Also known as 1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea, ABT 869, N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea

CAS 796967-16-3Formula C21H18FN5OMolar mass 375.41 g/molEC 681-638-2
GHS signal word: Danger. Pictograms: Serious health hazard, Hazardous to the environment 19 suppliers listed
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Linifanib chemical structure, C21H18FN5O, CAS 796967-16-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
796967-16-3
Formula
C21H18FN5O
Molar mass
375.41 g/mol
EC number
681-638-2
HS code
293399
Category
Screening compounds

What is Linifanib?

Plain description, key identifiers and synonyms

Linifanib is a member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 2-fluoro-5-methylphenyl group, while the other is substituted by a p-(3-amino-1H-indazol-4-yl)phenyl group. It is a potent, selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinases. It has a role as an antineoplastic agent, an angiogenesis inhibitor and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a member of phenylureas, an aromatic amine and a member of indazoles.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea
CAS number
796967-16-3 CAS number cross-checked
EC number
681-638-2
Molecular formula
C21H18FN5O
UNII
CO93X137CW
MDL number
MFCD11840918
InChIKey
MPVGZUGXCQEXTM-UHFFFAOYSA-N
InChI
InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
SMILES (canonical and isomeric)
CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N

Synonyms

  • 1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea
  • ABT 869
  • N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
  • 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea
  • linifanibum
  • N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea
  • N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea
  • Urea, N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)-
  • multitargeted receptor tyrosine kinase inhibitor ABT-869
  • Linifanib (ABT-869)
  • Linifanib (GMP)
  • 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea
  • Aminoindazole, 3
  • N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea, ABT 869
  • Kinome_532
  • ABT-869,Linifanib
  • AL 39324
  • Linifanib (USAN/INN)
  • 3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea
  • Linifanib (ABT-869)?
  • Sdccgsbi-0654273.p002
  • 1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
375.41 g/molcalc.
Exact mass
375.1495 Dacalc.
LogP (octanol/water)
4.9calc.
Topological polar surface area
95.83 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
28calc.
Rings
4calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.05calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1ccccc1)Nc1ccc(-c2cccc3[nH]ncc23)cc1

O=C(Nc1ccccc1)Nc1ccc(-c2cccc3[nH]ncc23)cc1

4 rings, 25 atoms.

1 other chemical share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H361Suspected of damaging fertility or the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (11)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Linifanib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 19 suppliers
19 of 19 offers
  • Twochem
    ChinaUnclaimed profile
    LinifanibGrade, purity and minimum order on request
    Price on request
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  • Notachem
    China ManufacturerUnclaimed profile
    LinifanibGrade, purity and minimum order on request
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  • VDM Biochemicals
    United States ManufacturerUnclaimed profile
    LinifanibGrade, purity and minimum order on request
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  • Aceschem Inc
    United States, FriscoUnclaimed profile
    LinifanibGrade, purity and minimum order on request
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  • Angel Pharmatech Ltd.
    China, ShanghaiUnclaimed profile
    LinifanibGrade, purity and minimum order on request
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  • Apexmol
    China, ChongqingUnclaimed profile
    LinifanibGrade, purity and minimum order on request
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  • Ark Pharma Scientific Limited
    China, WuhanUnclaimed profile
    LinifanibGrade, purity and minimum order on request
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  • AvaChem Scientific LLC
    United StatesUnclaimed profile
    LinifanibGrade, purity and minimum order on request
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  • Axon Medchem
    United States, RestonUnclaimed profile
    LinifanibGrade, purity and minimum order on request
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  • Capot
    China, HangzhouUnclaimed profile
    LinifanibGrade, purity and minimum order on request
    Price on request
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

19 suppliers in 3 countries

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Linifanib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • angiogenesis inhibitor
  • antineoplastic agent
  • enzyme inhibitor
  • ophthalmology drug
  • pharmaceutical
  • protein kinase inhibitor
  • tyrosine kinase inhibitor

Pharmacology

Linifanib is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Linifanib inhibits members of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor families, it exhibits much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. This agent does not have a general antiproliferative effect due to its high dose requirement. However, linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as FMS-related tyrosine kinase receptor-3 (FLT3).

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Linifanib is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Linifanib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Linifanib, based on the data on this page

What is Linifanib?

Linifanib is a member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 2-fluoro-5-methylphenyl group, while the other is substituted by a p-(3-amino-1H-indazol-4-yl)phenyl group.

What is the CAS number of Linifanib?

The CAS registry number of Linifanib is 796967-16-3.

What is the molecular formula and weight of Linifanib?

The molecular formula of Linifanib is C21H18FN5O and its molar mass is 375.41 g/mol.

What is Linifanib used for?

Known uses and roles of Linifanib include building blocks in research and laboratory, screening compounds in research and laboratory, angiogenesis inhibitor, antineoplastic agent, enzyme inhibitor and 4 more.

Is Linifanib hazardous?

Linifanib carries the GHS signal word "Danger". Main hazards: suspected of damaging fertility or the unborn child, causes damage to organs through prolonged or repeated exposure, very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Linifanib?

Linifanib is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Linifanib?

CompoundList lists 19 suppliers of Linifanib in China, United States and Canada. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Linifanib?

Suppliers quote Linifanib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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