CompoundList
Sign in
Cardiovascular and metabolic drugs

Lofexidine

Also known as 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole, Lofexidina, Lofexidinum

CAS 31036-80-3Formula C11H12Cl2N2OMolar mass 259.14 g/mol
8 suppliers listed Drug substance
Get quotes Compare 8 suppliers
Lofexidine chemical structure, C11H12Cl2N2O, CAS 31036-80-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
31036-80-3
Formula
C11H12Cl2N2O
Molar mass
259.14 g/mol
HS code
293329
Category
Cardiovascular and metabolic drugs

What is Lofexidine?

Plain description, key identifiers and synonyms

Lofexidine is a dichlorobenzene, a member of imidazoles, a carboxamidine and an aromatic ether. It has a role as an alpha-adrenergic agonist and an antihypertensive agent.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole
CAS number
31036-80-3 CAS number cross-checked
Molecular formula
C11H12Cl2N2O
UNII
UI82K0T627
InChIKey
KSMAGQUYOIHWFS-UHFFFAOYSA-N
InChI
InChI=1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15)
SMILES (canonical and isomeric)
CC(C1=NCCN1)OC2=C(C=CC=C2Cl)Cl

Synonyms

  • 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole
  • Lofexidina
  • Lofexidinum
  • 2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline
  • 2-(1-(2,6-Dichlorophenoxy)ethyl)-4,5-dihydro-1H-imidazole
  • 1H-Imidazole, 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-
  • 2-[1-(2,6-dichlorophenoxy)ethyl]-2-imidazoline
  • 1H-Imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-
  • 2-(1-(2,6-Dichlorophenoxy)ethyl)-2-imidazoline
  • 2-(alpha-(2,6-dichlorophenoxy)ethyl) delta-2-imidazoline
  • Britlofex
  • Lofexidine (INN)
  • Lofexidine (hydrochloride)
  • Baq-168, MDL-14042
  • Lucemyra
  • (+)-Lofexidine, (S)-(+)-Lofexidine
  • 31036-80-3 (free base)
  • Lofexidine - API Standards
  • 2-Imidazoline 2-(1-(2,6-dichlorophenoxy)ethyl)-
  • 2-{1-[(2,6-dichlorophenyl)oxy]ethyl}-4,5-dihydro-1H-imidazole
  • 2-(1-(26-dichlorophenoxy)ethyl)-45-dihydro-1H-imidazole
  • (+)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene
  • (-)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
259.14 g/molcalc.
Exact mass
258.0327 Dacalc.
LogP (octanol/water)
2.76calc.
Topological polar surface area
33.62 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
16calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.36calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(OCC2=NCCN2)cc1

c1ccc(OCC2=NCCN2)cc1

2 rings, 13 atoms, the 2-(Phenoxymethyl)-4,5-dihydro-1H-imidazole ring system.

49 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Lofexidine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 8 suppliers
8 of 8 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

8 suppliers in 4 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Lofexidine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Adrenergic alpha-2 Receptor Agonists
  • Antihypertensive Agents
  • Narcotic Antagonists

Roles

  • adrenergic agent
  • adrenergic agonist
  • alpha-adrenergic agonist
  • alpha-adrenergic drug
  • antihypertensive agent
  • cardiovascular drug
  • neurotransmitter agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Lofexidine is traded under.

HS 2933.29Indicative HS code

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…

World exports in 2024
$1.43B
−7.6% vs 2023, imports $1.47B
2019 to 2024
Top exporters
  1. China28.1%
  2. France * partner reported12.7%
  3. India * partner reported10.3%
Top importers
  1. United Kingdom13.0%
  2. United States7.9%
  3. China6.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Lofexidine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Lofexidine, based on the data on this page

What is Lofexidine?

Lofexidine is a dichlorobenzene, a member of imidazoles, a carboxamidine and an aromatic ether. It has a role as an alpha-adrenergic agonist and an antihypertensive agent.

What is the CAS number of Lofexidine?

The CAS registry number of Lofexidine is 31036-80-3.

What is the molecular formula and weight of Lofexidine?

The molecular formula of Lofexidine is C11H12Cl2N2O and its molar mass is 259.14 g/mol.

What is Lofexidine used for?

Known uses and roles of Lofexidine include antihypertensives in pharmaceuticals, cns agents in pharmaceuticals, adrenergic agent, adrenergic agonist, alpha-adrenergic agonist and 8 more.

Is Lofexidine hazardous?

No GHS hazard classification for Lofexidine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Lofexidine?

Lofexidine is usually classified under HS code 293329 (Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Lofexidine?

CompoundList lists 8 suppliers of Lofexidine in China, India, Italy and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Lofexidine in India?

1 supplier in India list Lofexidine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Lofexidine?

Suppliers quote Lofexidine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Lofexidine

Get quotes for Lofexidine

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Lofexidine
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Lofexidine with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/lofexidine-31036-80-3" title="Lofexidine structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Cardiovascular and metabolic drugs or HS code 293329

8 suppliers
Free quotes, contact stays private
Get quotes