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Oncology and immunology drugs

Lomustine

Also known as 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea, Belustine, CeeNU

CAS 13010-47-4Formula C9H16ClN3O2Molar mass 233.70 g/molEC 235-859-2
GHS signal word: Danger. Pictograms: Flammable, Acute toxicity (severe), Serious health hazard 107 suppliers listed Drug substance
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Lomustine chemical structure, C9H16ClN3O2, CAS 13010-47-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Solid
Melting point
90 °C
Solubility
Solubility in water, 0.1N NaOH, 0.1N HCl, or 10% ethanol: <0.05 mg/mL, in absolute ethan…
HS code
292429
Category
Oncology and immunology drugs
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Lomustine?

Plain description, key identifiers and synonyms

Lomustine is an N-nitrosourea that is urea in which one of the nitrogens is substituted by a 2-chloroethyl group and by a nitroso group, while the other nitrogen is substituted by a cyclohexyl group. An alkylating antineoplastic agent, it is used in the treatment of brain tumours, lung cancer, malignant melanoma and other solid tumours. It has a role as an alkylating agent and an antineoplastic agent. It is an organochlorine compound and a member of N-nitrosoureas.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
CAS number
13010-47-4 CAS number cross-checked
EC number
235-859-2
Molecular formula
C9H16ClN3O2
UNII
7BRF0Z81KG
MDL number
MFCD00012392
InChIKey
GQYIWUVLTXOXAJ-UHFFFAOYSA-N
InChI
InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
SMILES (canonical and isomeric)
C1CCC(CC1)NC(=O)N(CCCl)N=O

Synonyms

  • 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
  • Belustine
  • CeeNU
  • CCNU
  • Cecenu
  • CINU
  • Chloroethylcyclohexylnitrosourea
  • Lomustina
  • N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea
  • Urea, N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-
  • Lomustinum
  • Gleostine
  • Cyclohexyl chloroethyl nitrosourea
  • 1-(2-Chloroethyl)-3-cyclohexylnitrosourea
  • ICIG 1109
  • (Chloro-2-ethyl)-1-cyclohexyl-3-nitrosourea
  • RB 1509
  • (Cloro-2-etil)-1-cicloesil-3-nitrosourea
  • 3-(2-chloroethyl)-1-cyclohexyl-3-nitrosourea
  • Prava
  • CCN-U
  • 1-Nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-
  • 2-chloro-N-(cyclohexyl-C-hydroxycarbonimidoyl)-N-nitrosoethan-1-amine
  • Lomeblastin
  • Belustin
Show all 35 synonyms
  • Lucostin
  • Lucostine
  • chloroethylcyclo-hexylnitrosourea
  • Citostal
  • SRI 2200
  • Urea, 1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-
  • CCNU, NSC 79037
  • Lomustina (INN-Spanish)
  • CCNU [Chloroethyl nitrosoureas]
  • Lomustine, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Solidexp.
Melting point
90 °Cexp.
Solubility
Solubility in water, 0.1N NaOH, 0.1N HCl, or 10% ethanol: <0.05 mg/mL, in absolute ethanol: 70 mg/mLexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
233.70 g/molcalc.
Exact mass
233.0931 Dacalc.
LogP (octanol/water)
2.25calc.
Topological polar surface area
61.77 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
15calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.89calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CCCCC1

C1CCCCC1

1 ring, 6 atoms, the Cyclohexane ring system.

24,737 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS02: Flammable
Flammable
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H228Flammable solid.
  • H242Heating may cause a fire.
  • H301Toxic if swallowed.
  • H340May cause genetic defects.
  • H350May cause cancer.
  • H360May damage fertility or the unborn child.
  • H370Causes damage to organs.
  • H372Causes damage to organs through prolonged or repeated exposure.
Precautionary statements (23)
  • P203Obtain, read and follow all safety instructions before use.
  • P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P234Keep only in original packaging.
  • P235Keep cool.
  • P240Ground and bond container and receiving equipment.
  • P241Use explosion-proof electrical, ventilating and lighting equipment.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P308 + P316If exposed or concerned: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P370 + P378In case of fire: Use appropriate media to extinguish.
  • P403Store in a well-ventilated place.
  • P405Store locked up.
  • P410Protect from sunlight.
  • P411Store at temperatures not exceeding the specified limit.
  • P420Store separately.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Lomustine suppliers

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All 107 suppliers
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Where suppliers are based

107 suppliers in 18 countries

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Lomustine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Nitrosourea used in the treatment of certain neoplastic diseases.

Medicine: Antineoplastic.

Medication to treat brain tumors, Hodgkin's disease, and other kinds of cancer.

Industries and functions

Pharmacological actions

  • Antineoplastic Agents, Alkylating

Roles

  • aetiopathogenetic role
  • alkylating agent
  • antineoplastic agent
  • genotoxin
  • mutagen
  • pharmaceutical

Pharmacology

Lomustine is an Alkylating Drug. The mechanism of action of lomustine is as an Alkylating Activity.

How it is made

/Lomustine/ may be prepared by nitrosation of its substituted urea moiety, (1-(2-chloroethyl)-3-cyclohexylurea in a cold acid medium (e.g., formic acid)).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Lomustine is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Lomustine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Lomustine, based on the data on this page

What is Lomustine?

Lomustine is an N-nitrosourea that is urea in which one of the nitrogens is substituted by a 2-chloroethyl group and by a nitroso group, while the other nitrogen is substituted by a cyclohexyl group.

What is the CAS number of Lomustine?

The CAS registry number of Lomustine is 13010-47-4.

What is the molecular formula and weight of Lomustine?

The molecular formula of Lomustine is C9H16ClN3O2 and its molar mass is 233.70 g/mol.

What is Lomustine used for?

Nitrosourea used in the treatment of certain neoplastic diseases. Medicine: Antineoplastic. Medication to treat brain tumors, Hodgkin's disease, and other kinds of cancer.

Is Lomustine hazardous?

Lomustine carries the GHS signal word "Danger". Main hazards: flammable solid, heating may cause a fire, toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Lomustine?

Lomustine is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Lomustine?

CompoundList lists 107 suppliers of Lomustine in China, United States, Germany, United Kingdom and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Lomustine in India?

2 suppliers in India list Lomustine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Lomustine?

Suppliers quote Lomustine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Lomustine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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