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Impurities and reference standards

Loperamide oxide

Also known as Loperamide N-oxide, Loperamide EP impurity G, trans-Loperamide N-Oxide

CAS 106900-12-3Formula C29H33ClN2O3Molar mass 493.05 g/molEC 111-794-4
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 3 suppliers listed
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Loperamide oxide chemical structure, C29H33ClN2O3, CAS 106900-12-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
106900-12-3
Formula
C29H33ClN2O3
Molar mass
493.05 g/mol
EC number
111-794-4
HS code
293339
Category
Impurities and reference standards

What is Loperamide oxide?

Plain description, key identifiers and synonyms

Loperamide oxide is a diarylmethane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[4-(4-chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
CAS number
106900-12-3 CAS number cross-checkedOther or deprecated CAS: 109572-89-6, 217471-03-9
EC numbers
111-794-4, 641-544-4
Molecular formula
C29H33ClN2O3
UNII
NG66S4H2RL, YWT7AJ7O7P
InChIKey
KXVSBTJVTUVNPM-UHFFFAOYSA-N
InChI
InChI=1S/C29H33ClN2O3/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32(35)20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3
SMILES (canonical and isomeric)
CN(C)C(=O)C(CC[N+]1(CCC(CC1)(C2=CC=C(C=C2)Cl)O)[O-])(C3=CC=CC=C3)C4=CC=CC=C4

Synonyms

  • Loperamide N-oxide
  • Loperamide EP impurity G
  • trans-Loperamide N-Oxide
  • Arestal
  • Loperamide oxyde
  • Loperamide oxide anhydrous
  • Oxido de loperamida
  • Loperamide EP Impurity F
  • Loperamide oxide anhydrous, cis-
  • (1r,4s)-4-(4-chlorophenyl)-1-(4-(dimethylamino)-4-oxo-3,3-diphenylbutyl)-4-hydroxypiperidine 1-oxide
  • 4-[4-(4-chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
  • Loperamide oxide (INN)
  • 4-(4-chlorophenyl)-1-(4-(dimethylamino)-4-oxo-3,3-diphenylbutyl)-4-hydroxypiperidine 1-oxide
  • Loperamide EP Impurity G HCl
  • Loperamidum oxidum
  • trans-N-Oxide of loperamide
  • 4-(cis-4-(4-Chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-yl)-N,N-dimethyl-2,2-diphenylbutanamide
  • 4-[cis-4-(4-Chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
  • 4-[(1r,4s)-4-(4-Chlorophenyl)-4-hydroxy-1-oxo-1lambda~5~-piperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
  • cis-loperamide oxide
  • Loperamide Impurity F
  • Loperamide oxide, cis-
  • Loperamide oxide monohydrate CRS
  • 109572-89-6 (free base)
  • 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-, 1-oxide, (E)-
Show all 32 synonyms
  • 4-[cis-4-(4-Chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide (Loperamide cis-N-Oxide)
  • trans-4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutyramide 1-oxide
  • Loperamide hydrochloride specified impurity G
  • Loperamide hydrochloride impurity f
  • Loperamide hydrochloride impurity g
  • Loperamide oxide monohydrate impurity b
  • 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-, 1-oxide, cis-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
493.05 g/molcalc.
Exact mass
492.218 Dacalc.
LogP (octanol/water)
5.1calc.
Topological polar surface area
63.6 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
7calc.
Heavy atoms
35calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.35calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(C2CCN(CCC(c3ccccc3)c3ccccc3)CC2)cc1

c1ccc(C2CCN(CCC(c3ccccc3)c3ccccc3)CC2)cc1

4 rings, 27 atoms.

33 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Loperamide oxide suppliers

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All 3 suppliers

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Where suppliers are based

3 suppliers in 2 countries

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Loperamide oxide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Loperamide oxide is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Loperamide oxide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Loperamide oxide, based on the data on this page

What is Loperamide oxide?

Loperamide oxide is a diarylmethane.

What is the CAS number of Loperamide oxide?

The CAS registry number of Loperamide oxide is 106900-12-3. Other or deprecated CAS numbers: 109572-89-6, 217471-03-9.

What is the molecular formula and weight of Loperamide oxide?

The molecular formula of Loperamide oxide is C29H33ClN2O3 and its molar mass is 493.05 g/mol.

Is Loperamide oxide hazardous?

Loperamide oxide carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Loperamide oxide?

Loperamide oxide is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Loperamide oxide?

CompoundList lists 3 suppliers of Loperamide oxide in China and Czech Republic. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Loperamide oxide?

Suppliers quote Loperamide oxide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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