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Macitentan

Also known as Opsumit, Actelion-1, ACT 064992

CAS 441798-33-0Formula C19H20Br2N6O4SMolar mass 588.28 g/molEC 810-007-8
GHS signal word: Danger. Pictograms: Serious health hazard 89 suppliers listed Drug substance
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Macitentan chemical structure, C19H20Br2N6O4S, CAS 441798-33-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
441798-33-0
Formula
C19H20Br2N6O4S
Molar mass
588.28 g/mol
EC number
810-007-8
HS code
293359
Category
Pharmaceuticals and APIs

What is Macitentan?

Plain description, key identifiers and synonyms

Macitentan is a member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an antihypertensive agent, an endothelin receptor antagonist and an orphan drug. It is an aromatic ether, a ring assembly, an organobromine compound, a member of pyrimidines and a member of sulfamides. It is functionally related to an ethylene glycol and an ACT-132577.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine
CAS number
441798-33-0 CAS number cross-checked
EC number
810-007-8
Molecular formula
C19H20Br2N6O4S
UNII
Z9K9Y9WMVL
MDL number
MFCD17167076
InChIKey
JGCMEBMXRHSZKX-UHFFFAOYSA-N
InChI
InChI=1S/C19H20Br2N6O4S/c1-2-7-26-32(28,29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6,10-12,26H,2,7-9H2,1H3,(H,24,25,27)
SMILES (canonical and isomeric)
CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br

Synonyms

  • Opsumit
  • Actelion-1
  • ACT 064992
  • macitentanum
  • Opsynvi component macitentan
  • {[5-(4-Bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]sulfamoyl}(propyl)amine
  • n-(5-(4-bromophenyl)-6-(2-(5-bromopyrimidin-2-yloxy)ethoxy)pyrimidin-4-yl)-n'-propylaminosulfonamide
  • N-(5-(4-Bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxi)ethoxy)pyrimidin-4-yl)-N'-propylsulfuric diamide
  • N-(5-(4-Bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)-N'-propylsulfamide
  • N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]-N'-propylsulfuric diamide
  • ((5-(4-bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)sulfamoyl)(propyl)amine
  • N-(5-(4-Bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)-N'-propylsulfuric diamide
  • N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide
  • 5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine
  • N-(5-(4-Bromophenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-N'-propylsulfamide
  • C19H20Br2N6O4S
  • N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]-N'- propylsulfamide
  • Opsumit (TN)
  • Macitentan (Standard)
  • Macitentan (JAN/USAN)
  • Macitentan - Bio-X trade mark
  • cas:441798-33-0, Macitentan
  • Macitentan (Actelion-1,ACT-064992)
  • Macitentan (Actelion-1,ACT-064992)?
  • ACT 064992, ACT-064992
Show all 26 synonyms
  • Opsynvi (combination of macitentan + tadalafil)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
588.28 g/molcalc.
Exact mass
585.9633 Dacalc.
LogP (octanol/water)
3.57calc.
Topological polar surface area
128.2 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
11calc.
Heavy atoms
32calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.26calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(-c2cncnc2OCCOc2ncccn2)cc1

c1ccc(-c2cncnc2OCCOc2ncccn2)cc1

3 rings, 22 atoms.

18 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H360May damage fertility or the unborn child.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Macitentan suppliers

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All 89 suppliers
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Where suppliers are based

89 suppliers in 12 countries

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Macitentan price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Endothelin A Receptor Antagonists
  • Endothelin B Receptor Antagonists

Roles

  • antagonist
  • anti-ulcer drug
  • antifibrotic agent
  • antihypertensive agent
  • antineoplastic agent
  • cardiovascular drug
  • endothelin receptor antagonist
  • hormone antagonist
  • hormone receptor modulator
  • orphan drug
  • pharmaceutical
  • receptor modulator

Pharmacology

Macitentan is an Endothelin Receptor Antagonist. The mechanism of action of macitentan is as an Endothelin Receptor Antagonist.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Macitentan is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Macitentan is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Macitentan, based on the data on this page

What is Macitentan?

Macitentan is a member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hypertension.

What is the CAS number of Macitentan?

The CAS registry number of Macitentan is 441798-33-0.

What is the molecular formula and weight of Macitentan?

The molecular formula of Macitentan is C19H20Br2N6O4S and its molar mass is 588.28 g/mol.

What is Macitentan used for?

Known uses and roles of Macitentan include antagonist, anti-ulcer drug, antifibrotic agent, antihypertensive agent, antineoplastic agent and 9 more.

Is Macitentan hazardous?

Macitentan carries the GHS signal word "Danger". Main hazards: may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Macitentan?

Macitentan is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Macitentan?

CompoundList lists 89 suppliers of Macitentan in China, United States, India, Japan and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Macitentan in India?

11 suppliers in India list Macitentan on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Macitentan?

Suppliers quote Macitentan on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Macitentan

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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