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Heterocyclic building blocks

Mafosfamide

Also known as Mafosfamida, Mafosfamidum, 2-((2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl)thio)ethanesulfonic acid P-oxide

CAS 88859-04-5Formula C9H19Cl2N2O5PS2Molar mass 401.27 g/mol
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Mafosfamide chemical structure, C9H19Cl2N2O5PS2, CAS 88859-04-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
88859-04-5
Formula
C9H19Cl2N2O5PS2
Molar mass
401.27 g/mol
HS code
293499
Category
Heterocyclic building blocks

What is Mafosfamide?

Plain description, key identifiers and synonyms

Mafosfamide is a synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely related to cyclophosphamide, mafosfamide, unlike cyclophosphamide, does not require hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide, accordingly, mafosfamide is potentially useful in the intrathecal treatment of neoplastic meningitis. (NCI04)

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[[(2S,4S)-2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ5-oxazaphosphinan-4-yl]sulfanyl]ethanesulfonic acid
CAS number
88859-04-5 CAS number cross-checked
Molecular formula
C9H19Cl2N2O5PS2
UNII
5970HH9923
InChIKey
PBUUPFTVAPUWDE-UGZDLDLSSA-N
InChI
InChI=1S/C9H19Cl2N2O5PS2/c10-2-4-13(5-3-11)19(14)12-9(1-6-18-19)20-7-8-21(15,16)17/h9H,1-8H2,(H,12,14)(H,15,16,17)/t9-,19-/m0/s1
Canonical SMILES
O=P1(N(CCCl)CCCl)NC(SCCS(=O)(=O)O)CCO1
Isomeric SMILES
C1CO[P@@](=O)(N[C@H]1SCCS(=O)(=O)O)N(CCCl)CCCl

Synonyms

  • Mafosfamida
  • Mafosfamidum
  • 2-((2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl)thio)ethanesulfonic acid P-oxide
  • 2-(((2S,4S)-2-(bis(2-chloroethyl)amino)-2-oxo-1,3,2lambda5-oxazaphosphinan-4-yl)sulfanyl)ethane-1-sulfonic acid
  • Mafosfamid
  • (+-)-2-((2-(Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl)thio)ethanesulfonic acid P-cis-oxide
  • (+/-)-2-((2-(Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl)thio)ethanesulfonic acid p-cis-oxide
  • 2-({(2S,4S)-2-[Bis(2-chloroethyl)amino]-2-oxo-1,3,2lambda~5~-oxazaphosphinan-4-yl}sulfanyl)ethane-1-sulfonic acid
  • 2-[[(2S,4S)-2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2lambda5-oxazaphosphinan-4-yl]sulfanyl]ethanesulfonic acid
  • Ethanesulfonic acid, 2-(((2R,4R)-2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl)thio)-, rel-
  • Ethanesulfonic acid, 2-((2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl)thio)-, P-oxide, cis-(+-)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
401.27 g/molcalc.
Exact mass
399.985 Dacalc.
LogP (octanol/water)
1.83calc.
Topological polar surface area
95.94 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
9calc.
Heavy atoms
21calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=[PH]1NCCCO1

O=[PH]1NCCCO1

1 ring, 7 atoms.

197 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Mafosfamide suppliers

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Mafosfamide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Adjuvants, Immunologic
  • Antineoplastic Agents

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Mafosfamide is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Mafosfamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Mafosfamide, based on the data on this page

What is Mafosfamide?

Mafosfamide is a synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis.

What is the CAS number of Mafosfamide?

The CAS registry number of Mafosfamide is 88859-04-5.

What is the molecular formula and weight of Mafosfamide?

The molecular formula of Mafosfamide is C9H19Cl2N2O5PS2 and its molar mass is 401.27 g/mol.

What is Mafosfamide used for?

Known uses and roles of Mafosfamide include building blocks in research and laboratory, adjuvants, immunologic and antineoplastic agents.

Is Mafosfamide hazardous?

No GHS hazard classification for Mafosfamide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Mafosfamide?

Mafosfamide is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Mafosfamide?

Post a free request on CompoundList and suppliers of Mafosfamide will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Mafosfamide?

Suppliers quote Mafosfamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Mafosfamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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