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Cosmetic antioxidants

Matrine

Also known as (+)-Matrine, Vegard, (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one

CAS 519-02-8Formula C15H24N2OMolar mass 248.37 g/molEC 610-750-6
GHS signal word: Warning. Pictograms: Harmful or irritant 94 suppliers listed Drug substance
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Matrine chemical structure, C15H24N2O, CAS 519-02-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
519-02-8
Formula
C15H24N2O
Molar mass
248.37 g/mol
EC number
610-750-6
HS code
293979
Category
Cosmetic antioxidants

What is Matrine?

Plain description, key identifiers and synonyms

(+)-matrine has been reported in Sophora macrocarpa, Euchresta formosana, and other organisms.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one
CAS number
519-02-8 CAS number cross-checked
EC number
610-750-6
Molecular formula
C15H24N2O
UNII
N390W430AC
MDL number
MFCD00210527
INCI name
MATRINE
InChIKey
ZSBXGIUJOOQZMP-JLNYLFASSA-N
InChI
InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1
Canonical SMILES
O=C1CCCC2C3CCCN4CCCC(CN12)C34
Isomeric SMILES
C1C[C@@H]2[C@H]3CCCN4[C@H]3[C@@H](CCC4)CN2C(=O)C1

Synonyms

  • (+)-Matrine
  • Vegard
  • (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one
  • (1R,2R,9S,17S)-7,13-diazatetracyclo(7.7.1.02,7.013,17)heptadecan-6-one
  • 2,6-diamino-5-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl)oxy-1H-pyrimidin-4-one
  • 7,13-diazatetracyclo(7.7.1.02,7.013,17)heptadecan-6-one
  • Ex Sophporae Radix
  • (7aS,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
  • Matrene, (+)-
  • (41S,7aS,13aR,13bR)-Dodecahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(41H)-one
  • Alpha Matrine
  • alpha-Matrine
  • Lupanidine
  • Matrine CRS
  • Matrine (Standard)
  • Matridin-15-one,
  • 5-24-02-00301 (Beilstein Handbook Reference)
  • Matridin-15-one, Vegard, -Matrine
  • Matridin-15-one, Vegard, alpha-Matrine
  • Matrine 100 microg/mL in Acetonitrile
  • (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadecan-6-one
  • (4(1)S,7aS,13aR,13bR)-dodecahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(4(1)H)-one
  • (7aS,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]napthyridin-10-one
  • (7aS,13aR,13bS,13cS)dodecahydro-1H,5H,10H-dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10-one
  • 1H,5H,10H-Dipyrido(2,1-f:3',2',1'-ij)(1,6)naphthyridin-10-one, dodecahydro-, (7as,13ar,13br,13cs)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
248.37 g/molcalc.
Exact mass
248.1889 Dacalc.
LogP (octanol/water)
1.87calc.
Topological polar surface area
23.55 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
0calc.
Heavy atoms
18calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.93calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCCC2C3CCCN4CCCC(CN12)C34

O=C1CCCC2C3CCCN4CCCC(CN12)C34

4 rings, 18 atoms, the Matridin-15-one ring system.

16 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H319Causes serious eye irritation.
Precautionary statements (9)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P330Rinse mouth.
  • P337 + P317If eye irritation persists: Get medical help.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Matrine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 94 suppliers
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Where suppliers are based

94 suppliers in 14 countries

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Matrine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name MATRINE(antioxidant, skin conditioning)

Functional uses

  • Antioxidant
  • Softener and conditioner

Cosmetic functions

  • Antioxidant
  • Skin conditioning

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Matrine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Matrine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Matrine, based on the data on this page

What is Matrine?

(+)-matrine has been reported in Sophora macrocarpa, Euchresta formosana, and other organisms.

What is the CAS number of Matrine?

The CAS registry number of Matrine is 519-02-8.

What is the molecular formula and weight of Matrine?

The molecular formula of Matrine is C15H24N2O and its molar mass is 248.37 g/mol.

What is Matrine used for?

Known uses and roles of Matrine include antioxidants in cosmetics and personal care, skin conditioning agents in cosmetics and personal care, antioxidant, skin conditioning and softener and conditioner.

Is Matrine hazardous?

Matrine carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Matrine?

Matrine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Matrine?

CompoundList lists 94 suppliers of Matrine in China, United States, United Kingdom, Germany and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Matrine in India?

2 suppliers in India list Matrine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Matrine?

Suppliers quote Matrine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Matrine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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