Mefenamic acid
Also known as Ponstel, 2-[(2,3-dimethylphenyl)amino]benzoic acid, Mephenamic acid
Key facts
What buyers check first
- Appearance
- Crystals
- Melting point
- 230 to 231
- Solubility
- WHITE POWDER, SOLUBILITY IN WATER: GREATER THAN 5 G/100 ML /SODIUM SALT/
- HS code
- 292249
- Category
- Analgesics and anti-inflammatories

What is Mefenamic acid?
Plain description, key identifiers and synonyms
Mefenamic acid is an aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis. It has a role as a non-steroidal anti-inflammatory drug, an analgesic, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a xenobiotic, an antirheumatic drug and an environmental contaminant. It is an aminobenzoic acid and a secondary amino compound.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- 2-(2,3-dimethylanilino)benzoic acid
- CAS number
- 61-68-7 CAS number cross-checked
- EC number
- 200-513-1
- Molecular formula
- C15H15NO2
- UNII
- 367589PJ2C
- MDL number
- MFCD00051721
- InChIKey
- HYYBABOKPJLUIN-UHFFFAOYSA-N
- InChI
- InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)
- SMILES (canonical and isomeric)
- CC1=C(C(=CC=C1)NC2=CC=CC=C2C(=O)O)C
Synonyms
- Ponstel
- 2-[(2,3-dimethylphenyl)amino]benzoic acid
- Mephenamic acid
- 2-((2,3-Dimethylphenyl)amino)benzoic acid
- Mephenaminic acid
- Ponstan
- Methenamic acid
- Vialidon
- Lysalgo
- Tanston
- Acide mefenamique
- Mefenaminsaeure
- N-2,3-Xylylanthranilic acid
- Acido mefenamico
- Mefenaminic Acid
- Acidum mefenamicum
- INF 3355
- N-(2,3-Xylyl)-2-aminobenzoic acid
- N-(2,3-Dimethylphenyl)anthranilic acid
- Gardan
- Anthranilic acid, N-2,3-xylyl-
- 2-(2,3-dimethylphenylamino)benzoic acid
- Benzoic acid, 2-[(2,3-dimethylphenyl)amino]-
- CN 35355
- Benzoic acid, 2-(2,3-dimethylphenyl)amino-
Show all 38 synonymsShow fewer synonyms
- Benzoic acid, 2-((2,3-dimethylphenyl)amino)-
- 2-Diphenylaminecarboxylic acid, 2',3'-dimethyl-
- Mefenamicacid
- Mendys
- Ponstan fte
- Opustan 250
- Opustan 500
- Dysman-250
- Dysman-500
- Meflam 250
- Meflam 500
- Acid, Mefenamic
- Apo Mefenamic
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
| Appearance | Crystalsexp.Measured value |
|---|---|
| Melting point | 230 to 231exp.Measured value |
| Solubility | WHITE POWDER, SOLUBILITY IN WATER: GREATER THAN 5 G/100 ML /SODIUM SALT/exp.Measured value |
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 241.29 g/molcalc.Computed value |
|---|---|
| Exact mass | 241.1103 Dacalc.Computed value |
| LogP (octanol/water) | 3.75calc.Computed value |
| Topological polar surface area | 49.33 ร
ยฒcalc.Computed value |
| Hydrogen bond donors | 2calc.Computed value |
| Hydrogen bond acceptors | 2calc.Computed value |
| Rotatable bonds | 3calc.Computed value |
| Heavy atoms | 18calc.Computed value |
| Rings | 2calc.Computed value |
| Aromatic rings | 2calc.Computed value |
| Fraction sp3 carbons | 0.13calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 0calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
c1ccc(Nc2ccccc2)cc1
2 rings, 13 atoms, the Diphenylamine ring system.
3,181 other chemicals share this scaffoldSafety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H302Harmful if swallowed.
- H361Suspected of damaging fertility or the unborn child.
Precautionary statements (9)
- P203Obtain, read and follow all safety instructions before use.
- P264Wash skin thoroughly after handling.
- P270Do not eat, drink or smoke when using this product.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
- P301 + P317If swallowed: Get medical help.
- P318If exposed or concerned, get medical advice.
- P330Rinse mouth.
- P405Store locked up.
- P501Dispose of contents and container in accordance with local regulations.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidMefenamic acid suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
- India, Mumbai ManufacturerUnclaimed profileMefenamic AcidGrade, purity and minimum order on requestPrice on request
- China, Zibo ManufacturerUnclaimed profileMefenamic AcidGrade, purity and minimum order on requestPrice on request
- Japan, Chiyoda-KuUnclaimed profileMefenamic AcidGrade, purity and minimum order on requestPrice on request
- Taiwan, Taichung City ManufacturerUnclaimed profileMefenamic AcidGrade, purity and minimum order on requestPrice on request
- ChinaUnclaimed profileMefenamic AcidGrade, purity and minimum order on requestPrice on request
- ChinaUnclaimed profileMefenamic AcidGrade, purity and minimum order on requestPrice on request
- India, ThaneUnclaimed profileMefenamic AcidGrade, purity and minimum order on requestPrice on request
- India, IndoreUnclaimed profileMefenamic AcidGrade, purity and minimum order on requestPrice on request
- India ManufacturerUnclaimed profileMefenamic AcidGrade, purity and minimum order on requestPrice on request
- India, Navi MumbaiUnclaimed profileMefenamic AcidGrade, purity and minimum order on requestPrice on request
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Where suppliers are based
178 suppliers in 29 countries
- India43
- United States42
- China39
- Germany5
- United Kingdom5
- Spain3
- and 23 more countries
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Mefenamic acid price
Indicative price range per kg from live supplier offers
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Uses and applications
What the substance is used for, by industry and function
Use classes: Pharmaceuticals.
Industries and functions
Pharmacological actions
- Anti-Inflammatory Agents, Non-Steroidal
- Cyclooxygenase Inhibitors
Roles
- analgesic
- anti-inflammatory agent
- anti-inflammatory drug
- antipyretic
- antirheumatic drug
- environmental contaminant
- enzyme inhibitor
- hypoglycemic agent
- non-steroidal anti-inflammatory drug
- pharmaceutical
- xenobiotic
Functional uses
- Pharmaceutical
Pharmacology
Mefenamic acid is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of mefenamic acid is as a Cyclooxygenase Inhibitor.
How it is made
Prepd by copper-catalyzed condensation of o-chlorobenzoic acid & 2,3-dimethylaniline: winder...j pharmacol exp ther 138, 405 (1962), belg patent 605,302 (1961 to parke, davis).
O-chlorobenozic acid is condensed with 2,3-xylidene with aid of potassium carbonate & resulting potassium salt is treated with mineral acid to liberate desired acid. Us patent 3,138,636.
Regulatory status
Inventories, regulations and trade controls that list this substance
Health and food
- Active ingredient in FDA approved drug labels
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Mefenamic acid is traded under.
Amino-acids, other than those containing more than one kind of oxygen function, andโฆ
- United States13.4%
- Germany11.1%
- Japan6.6%
* Partner reported figures, a lower bound.
The HS code shown for Mefenamic acid is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Frequently asked questions
Quick answers about Mefenamic acid, based on the data on this page
What is Mefenamic acid?
What is the CAS number of Mefenamic acid?
What is the molecular formula and weight of Mefenamic acid?
What is Mefenamic acid used for?
Is Mefenamic acid hazardous?
What is the HS code of Mefenamic acid?
Where can I buy Mefenamic acid?
Where can I buy Mefenamic acid in India?
What is the price of Mefenamic acid?
Guides for buyers
Practical guides that help when you source, ship or handle Mefenamic acid
- Article, QualityPharma grades explained: IP vs BP vs USP vs EPWhat the Indian, British, US and European pharmacopoeias are, how their monographs differ, what multi grade claims mean and why a grade alone does not make a product fit for medicines.Read
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, SafetyGHS pictograms, signal words and hazard statements explainedA practical guide to the nine GHS pictograms, the signal words Danger and Warning, H and P statements, and how to read a chemical label in seconds.Read
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