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Heterocyclic building blocks

Mefuparib

Also known as CVL-218 free base, 5-Fluoro-2-(4-((methylamino)methyl)phenyl)-7-benzofurancarboxamide, 5-fluoro-2-{4-[(methylamino)methyl]phenyl}-1-benzofuran-7-carboxamide

CAS 1392502-82-7Formula C17H15FN2O2Molar mass 298.32 g/mol
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Mefuparib chemical structure, C17H15FN2O2, CAS 1392502-82-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1392502-82-7
Formula
C17H15FN2O2
Molar mass
298.32 g/mol
HS code
293299
Category
Heterocyclic building blocks

What is Mefuparib?

Plain description, key identifiers and synonyms

Mefuparib is a member of the class of 1-benzofurans that is 1-benzofuran substituted by 4-[(methylamino)methyl]phenyl, fluoro and aminocarbonyl groups at positions 2, 5, and 7, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 3.2 nM and 1.9 nM, respectively). The compound exhibits anti-cancer properties and has also shown promising antiviral activity against the virus that causes COVID-19. It has a role as an anticoronaviral agent, an antineoplastic agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and an apoptosis inducer. It is a primary carboxamide, an organofluorine compound, a member of 1-benzofurans and a secondary amino compound. It is a conjugate base of a mefuparib(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-fluoro-2-[4-(methylaminomethyl)phenyl]-1-benzofuran-7-carboxamide
CAS number
1392502-82-7
Molecular formula
C17H15FN2O2
UNII
9NN2OZ1YX4
InChIKey
ROBJKLPZIPNAMV-UHFFFAOYSA-N
InChI
InChI=1S/C17H15FN2O2/c1-20-9-10-2-4-11(5-3-10)15-7-12-6-13(18)8-14(17(19)21)16(12)22-15/h2-8,20H,9H2,1H3,(H2,19,21)
SMILES (canonical and isomeric)
CNCC1=CC=C(C=C1)C2=CC3=CC(=CC(=C3O2)C(=O)N)F

Synonyms

  • CVL-218 free base
  • 5-Fluoro-2-(4-((methylamino)methyl)phenyl)-7-benzofurancarboxamide
  • 5-fluoro-2-{4-[(methylamino)methyl]phenyl}-1-benzofuran-7-carboxamide
  • 5-Fluoro-2-[4-[(methylamino)methyl]phenyl]-7-benzofurancarboxamide
  • 5-fluoro-2-(4-((methylamino)methyl)phenyl)-1-benzofuran-7-carboxamide
  • Mefuparib Free Base
  • 5-fluoro-2-{4-[(methylamino)methyl]phenyl}-benzofuran-7-carboxamide
  • 5-fluoro-2-{4-[(methylamino)methyl]phenyl}benzofuran-7-carboxamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
298.32 g/molcalc.
Exact mass
298.1118 Dacalc.
LogP (octanol/water)
3.06calc.
Topological polar surface area
68.26 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
22calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.12calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(-c2cc3ccccc3o2)cc1

c1ccc(-c2cc3ccccc3o2)cc1

3 rings, 15 atoms, the 2-Phenyl-benzofuran ring system.

505 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Mefuparib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

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Mefuparib price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • anticoronaviral agent
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • apoptosis inducer
  • enzyme inhibitor
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Mefuparib is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Mefuparib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Mefuparib, based on the data on this page

What is Mefuparib?

Mefuparib is a member of the class of 1-benzofurans that is 1-benzofuran substituted by 4-[(methylamino)methyl]phenyl, fluoro and aminocarbonyl groups at positions 2, 5, and 7, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 3.2 nM and 1.9 nM, respectively).

What is the CAS number of Mefuparib?

The CAS registry number of Mefuparib is 1392502-82-7.

What is the molecular formula and weight of Mefuparib?

The molecular formula of Mefuparib is C17H15FN2O2 and its molar mass is 298.32 g/mol.

What is Mefuparib used for?

Known uses and roles of Mefuparib include building blocks in research and laboratory, screening compounds in research and laboratory, anticoronaviral agent, antimicrobial agent, antineoplastic agent and 4 more.

Is Mefuparib hazardous?

No GHS hazard classification for Mefuparib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Mefuparib?

Mefuparib is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Mefuparib?

Post a free request on CompoundList and suppliers of Mefuparib will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Mefuparib?

Suppliers quote Mefuparib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Mefuparib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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