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Antibiotics and anti-infectives

Methicillin

Also known as Meticillin, Methycillin, Metacillin

CAS 61-32-5Formula C17H20N2O6SMolar mass 380.42 g/molEC 200-505-8
GHS signal word: Warning. Pictograms: Harmful or irritant 26 suppliers listed
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Methicillin chemical structure, C17H20N2O6S, CAS 61-32-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
61-32-5
Formula
C17H20N2O6S
Molar mass
380.42 g/mol
Solubility
FINE, WHITE, CRYSTALLINE POWDER, FREELY SOL IN METHANOL, PYRIDINE, SLIGHTLY SOL IN PROPY…
HS code
294110
Category
Antibiotics and anti-infectives

What is Methicillin?

Plain description, key identifiers and synonyms

Methicillin is a penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group. It has a role as an antibacterial drug. It is a penicillin and a penicillin allergen. It is a conjugate acid of a methicillin(1-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
CAS number
61-32-5 CAS number cross-checked
EC number
200-505-8
Molecular formula
C17H20N2O6S
UNII
Q91FH1328A
InChIKey
RJQXTJLFIWVMTO-TYNCELHUSA-N
InChI
InChI=1S/C17H20N2O6S/c1-17(2)12(16(22)23)19-14(21)11(15(19)26-17)18-13(20)10-8(24-3)6-5-7-9(10)25-4/h5-7,11-12,15H,1-4H3,(H,18,20)(H,22,23)/t11-,12+,15-/m1/s1
Canonical SMILES
COc1cccc(OC)c1C(=O)NC1C(=O)N2C1SC(C)(C)C2C(=O)O
Isomeric SMILES
CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)C3=C(C=CC=C3OC)OC)C(=O)O)C

Synonyms

  • Meticillin
  • Methycillin
  • Metacillin
  • Dimocillin
  • Methicillinum
  • Meticilina
  • Meticilline
  • Meticillinum
  • Meticillina
  • (2,6-Dimethoxyphenyl)penicillin
  • 6-(2,6-Dimethoxybenzamido)penicillanic acid
  • (2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • Penicillin, (2,6-dimethoxyphenyl)-
  • 2,6-dimethoxyphenyl penicillin
  • 6beta-(2,6-dimethoxybenzamido)penicillanic acid
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((2,6-dimethoxybenzoyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2,6-dimethoxybenzamido)-3,3,-dimethyl-7-oxo-
  • Penicillin, Dimethoxyphenyl
  • Methicillin Monohydrate, Monosodium Salt
  • (2S,5R,6R)-6-((2,6-dimethoxybenzene)amido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
  • (2S,5R,6R)-6-((2,6-dimethoxybenzoyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
  • (2S,5R,6R)-6-[(2,6-dimethoxybenzene)amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • Dimethoxyphenyl Penicillin
  • BRL 1241
Show all 28 synonyms
  • (2S,5R,6R)-6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • Methcillin
  • (2S,5R,6R)-6-(2,6-Dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Solubility
FINE, WHITE, CRYSTALLINE POWDER, FREELY SOL IN METHANOL, PYRIDINE, SLIGHTLY SOL IN PROPYL AND AMYL ALCOHOL, ETHYLENE CHLORIDE, INSOL IN BENZENE, ODORLESS OR HAVING SLIGHT ODOR /METHICILLIN SODIUM/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
380.42 g/molcalc.
Exact mass
380.1042 Dacalc.
LogP (octanol/water)
0.95calc.
Topological polar surface area
105.2 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
5calc.
Heavy atoms
26calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.47calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(NC1C(=O)N2CCSC12)c1ccccc1

O=C(NC1C(=O)N2CCSC12)c1ccccc1

3 rings, 17 atoms.

9 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Methicillin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 26 suppliers
26 of 26 offers
  • 001Chemical
    China, HangzhouUnclaimed profile
    MethicillinGrade, purity and minimum order on request
    Price on request
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  • AbaChemScene, LLC
    United States, Monmouth JunctionUnclaimed profile
    MethicillinGrade, purity and minimum order on request
    Price on request
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  • AiFChem
    United States, SomervilleUnclaimed profile
    MethicillinGrade, purity and minimum order on request
    Price on request
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  • AKos Consulting & Solutions
    Germany, LorrachUnclaimed profile
    MethicillinGrade, purity and minimum order on request
    Price on request
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  • Alfa Chemistry
    United States, HolbrookUnclaimed profile
    MethicillinGrade, purity and minimum order on request
    Price on request
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  • Ambinter
    France, OrleansUnclaimed profile
    MethicillinGrade, purity and minimum order on request
    Price on request
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  • BenchChem
    United States, AustinUnclaimed profile
    MethicillinGrade, purity and minimum order on request
    Price on request
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  • Biorbyt Ltd.
    United Kingdom, CambridgeUnclaimed profile
    MethicillinGrade, purity and minimum order on request
    Price on request
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  • BLD Pharm
    China, ShanghaiUnclaimed profile
    MethicillinGrade, purity and minimum order on request
    Price on request
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  • BOC Sciences
    United States, New YorkUnclaimed profile
    MethicillinGrade, purity and minimum order on request
    Price on request
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

26 suppliers in 10 countries

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Methicillin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Pharmacological actions

  • Anti-Bacterial Agents

Roles

  • antibacterial agent
  • antibacterial drug
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • pharmaceutical

Pharmacology

Methicillin is a semisynthetic, narrow spectrum beta-lactamase-resistant penicillin antibiotic with bactericidal and beta-lactamase resistant activity. Methicillin binds to specific penicillin-binding proteins (BPBs) on the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to an interruption of the bacterial cell wall and causes bacterial lysis.

How it is made

Fermentation-produced 6-aminopenicillanic acid is condensed with 2,6-dimethoxybenzoyl chloride in suitable organic solvent & resulting methicillin is pptd as sodium salt by addn of sodium acetate. (Methicillin sodium)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Methicillin is traded under.

HS 2941.10Indicative HS code

Penicillins and their derivatives with a penicillanic acid structure, salts thereof

World exports in 2024
$1.66B
−2.5% vs 2023, imports $1.63B
2019 to 2024
Top exporters
  1. China56.8%
  2. Spain13.1%
  3. India * partner reported7.7%
Top importers
  1. India * partner reported16.4%
  2. Austria9.3%
  3. Brazil5.4%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Methicillin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Methicillin, based on the data on this page

What is Methicillin?

Methicillin is a penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group. It has a role as an antibacterial drug. It is a penicillin and a penicillin allergen. It is a conjugate acid of a methicillin(1-).

What is the CAS number of Methicillin?

The CAS registry number of Methicillin is 61-32-5.

What is the molecular formula and weight of Methicillin?

The molecular formula of Methicillin is C17H20N2O6S and its molar mass is 380.42 g/mol.

What is Methicillin used for?

Veterinary medication:.

Is Methicillin hazardous?

Methicillin carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Methicillin?

Methicillin is usually classified under HS code 294110 (Penicillins and their derivatives with a penicillanic acid structure, salts thereof). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Methicillin?

CompoundList lists 26 suppliers of Methicillin in United States, China, Germany, Spain and 6 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Methicillin in India?

1 supplier in India list Methicillin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Methicillin?

Suppliers quote Methicillin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Methicillin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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