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Methotrexate-alpha glutamate

Also known as Meapa-glu-glu, L-Glutamic acid, N-(N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-alpha-glutamyl)-, 2-[[4-carboxy-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]butanoyl]amino]pentanedioic acid

CAS 71074-49-2Formula C25H29N9O8Molar mass 583.56 g/mol
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Methotrexate-alpha glutamate chemical structure, C25H29N9O8, CAS 71074-49-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
71074-49-2
Formula
C25H29N9O8
Molar mass
583.56 g/mol
HS code
293359
Category
Peptides

What is Methotrexate-alpha glutamate?

Plain description, key identifiers and synonyms

Methotrexate-alpha glutamate is a chemical substance with the molecular formula C25H29N9O8 and a molar mass of 583.56 g/mol. Its CAS registry number is 71074-49-2. The IUPAC name is 2-[[4-carboxy-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]butanoyl]amino]pentanedioic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[[4-carboxy-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]butanoyl]amino]pentanedioic acid
CAS number
71074-49-2 CAS number cross-checked
Molecular formula
C25H29N9O8
InChIKey
GCHKEUJNMCBNBS-UHFFFAOYSA-N
InChI
InChI=1S/C25H29N9O8/c1-34(11-13-10-28-21-19(29-13)20(26)32-25(27)33-21)14-4-2-12(3-5-14)22(39)30-15(6-8-17(35)36)23(40)31-16(24(41)42)7-9-18(37)38/h2-5,10,15-16H,6-9,11H2,1H3,(H,30,39)(H,31,40)(H,35,36)(H,37,38)(H,41,42)(H4,26,27,28,32,33)
SMILES (canonical and isomeric)
CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)O

Synonyms

  • Meapa-glu-glu
  • L-Glutamic acid, N-(N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-alpha-glutamyl)-
  • 2-[[4-carboxy-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]butanoyl]amino]pentanedioic acid
  • L-Glutamic acid,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-alpha-glutamyl]-
  • N-[2-(4-{[(4-Amino-2-imino-2,3-dihydropteridin-6-yl)methyl](methyl)amino}benzamido)-4-carboxy-1-hydroxybutylidene]glutamic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
583.56 g/molcalc.
Exact mass
583.2139 Dacalc.
LogP (octanol/water)
-0.38calc.
Topological polar surface area
276.9 Ųcalc.
Hydrogen bond donors
7calc.
Hydrogen bond acceptors
12calc.
Rotatable bonds
14calc.
Heavy atoms
42calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.32calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(NCc2cnc3ncncc3n2)cc1

c1ccc(NCc2cnc3ncncc3n2)cc1

3 rings, 18 atoms.

202 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Methotrexate-alpha glutamate suppliers

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Methotrexate-alpha glutamate price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Methotrexate-alpha glutamate is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Methotrexate-alpha glutamate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Methotrexate-alpha glutamate, based on the data on this page

What is Methotrexate-alpha glutamate?

Methotrexate-alpha glutamate is a chemical substance with the molecular formula C25H29N9O8 and a molar mass of 583.56 g/mol. Its CAS registry number is 71074-49-2. The IUPAC name is 2-[[4-carboxy-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]butanoyl]amino]pentanedioic acid.

What is the CAS number of Methotrexate-alpha glutamate?

The CAS registry number of Methotrexate-alpha glutamate is 71074-49-2.

What is the molecular formula and weight of Methotrexate-alpha glutamate?

The molecular formula of Methotrexate-alpha glutamate is C25H29N9O8 and its molar mass is 583.56 g/mol.

Is Methotrexate-alpha glutamate hazardous?

No GHS hazard classification for Methotrexate-alpha glutamate is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Methotrexate-alpha glutamate?

Methotrexate-alpha glutamate is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Methotrexate-alpha glutamate?

Post a free request on CompoundList and suppliers of Methotrexate-alpha glutamate will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Methotrexate-alpha glutamate?

Suppliers quote Methotrexate-alpha glutamate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Methotrexate-alpha glutamate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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