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Pharmaceuticals and APIs

Metra

Also known as Phendimetrazine tartrate, Statobex, Plegine

CAS 50-58-8Formula C16H23NO7Molar mass 341.36 g/molEC 200-051-0
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant Drug substance
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Metra chemical structure, C16H23NO7, CAS 50-58-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
50-58-8
Formula
C16H23NO7
Molar mass
341.36 g/mol
EC number
200-051-0
HS code
293499
Category
Pharmaceuticals and APIs

What is Metra?

Plain description, key identifiers and synonyms

Phendimetrazine Tartrate is a phenylalkylamine sympathomimetic amine with appetite depressant property. Phendimetrazine tartrate is a prodrug that is hydrolyzed to the active metabolite phenmetrazine, which competes with norepinephrine and dopamine for their presynaptic transporters, thereby blocks the reuptake of these monoamines at the neuronal junctions. As a result, this prolongs activities of dopamine and norepinephrine and leads to central nervous system (CNS) stimulation and metabolic effects, including appetite-suppression, decreased gastric acid secretion and increased blood pressure.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2R,3R)-2,3-dihydroxybutanedioic acid, (2S,3S)-3,4-dimethyl-2-phenylmorpholine
CAS number
50-58-8 CAS number cross-checked
EC number
200-051-0
Molecular formula
C16H23NO7
UNII
6985IP0T80
InChIKey
VEPOHXYIFQMVHW-PVJVQHJQSA-N
InChI
InChI=1S/C12H17NO.C4H6O6/c1-10-12(14-9-8-13(10)2)11-6-4-3-5-7-11;5-1(3(7)8)2(6)4(9)10/h3-7,10,12H,8-9H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t10-,12+;1-,2-/m01/s1
Canonical SMILES
CC1C(c2ccccc2)OCCN1C.O=C(O)C(O)C(O)C(=O)O
Isomeric SMILES
C[C@H]1[C@@H](OCCN1C)C2=CC=CC=C2.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O

Synonyms

  • Phendimetrazine tartrate
  • Statobex
  • Plegine
  • Adphen
  • Alphazine
  • Cam-metrazine
  • Bontril pdm
  • di-Metrex
  • Statobex-g
  • SPRX-3
  • SPRX-105
  • Phenazine-35
  • Melfiat-105
  • X-trozine L.A.
  • Appecon
  • Morpholine, 3,4-dimethyl-2-phenyl-, tartrate, D-
  • Phendimetrazine tartrate ciii
  • Phendimetrazine tartrate (USP)
  • Phendimetrazine tartrate er
  • (2S,3S)-3,4-Dimethyl-2-phenylmorpholine L-(+)-tartrate(1:1)
  • Morpholine, 3,4-dimethyl-2-phenyl-,(2S,3S)-,(2R,3R)-2,3-dihydroxybutanedioate(1:1)
  • x-Trozine
  • Melfiat
  • Phendimetrazine hydrogen tartrate
  • Adipost
Show all 36 synonyms
  • Prelu 2
  • Prelu-2
  • SPRX
  • (2S,3S)-3,4-Dimethyl-2-phenylmorpholine L-tartrate
  • D-3,4-Dimethyl-2-phenyl-morpholine tartrate
  • Statobex (TN)
  • Bontril (TN)
  • Sodium alginate, viscosity ~100mp.s
  • (2S,3S)-3,4-Dimethyl-2-phenylmorpholine L-(+)-tartrate (1:1)
  • Morpholine, 3,4-dimethyl-2-phenyl-, (2S-trans)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1)
  • Morpholine, 3,4-dimethyl-2-phenyl-, (+)-, tartrate (1:1)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
341.36 g/molcalc.
Exact mass
341.1475 Dacalc.
LogP (octanol/water)
-0.04calc.
Topological polar surface area
127.5 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
4calc.
Heavy atoms
24calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
4calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(C2CNCCO2)cc1

c1ccc(C2CNCCO2)cc1

2 rings, 12 atoms, the 2-Phenylmorpholine ring system.

1,017 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H301Toxic if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H332Harmful if inhaled.
Precautionary statements (18)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Metra suppliers

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Metra price

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Metra is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Metra is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Metra, based on the data on this page

What is Metra?

Phendimetrazine Tartrate is a phenylalkylamine sympathomimetic amine with appetite depressant property.

What is the CAS number of Metra?

The CAS registry number of Metra is 50-58-8.

What is the molecular formula and weight of Metra?

The molecular formula of Metra is C16H23NO7 and its molar mass is 341.36 g/mol.

Is Metra hazardous?

Metra carries the GHS signal word "Danger". Main hazards: toxic if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Metra?

Metra is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Metra?

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What is the price of Metra?

Suppliers quote Metra on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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