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Cardiovascular and metabolic drugs

Midodrine

Also known as Midodrin, Midodrina, Midodrinum

CAS 42794-76-3Formula C12H18N2O4Molar mass 254.29 g/molEC 255-945-3
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 46 suppliers listed Drug substance
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Midodrine chemical structure, C12H18N2O4, CAS 42794-76-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
42794-76-3
Formula
C12H18N2O4
Physical form
Solid
Melting point
150 °C
HS code
292429
Category
Cardiovascular and metabolic drugs
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Midodrine?

Plain description, key identifiers and synonyms

Midodrine is an aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine. It has a role as a sympathomimetic agent, an alpha-adrenergic agonist, a prodrug and a vasoconstrictor agent. It is an amino acid amide, an aromatic ether and a secondary alcohol. It is functionally related to a glycinamide and a deglymidodrine. It is a conjugate base of a midodrine(1+).

Midodrine is a peripheral alpha-1 agonist used for the treatment of dysautonomia and orthostatic hypotension.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide
CAS number
42794-76-3 CAS number cross-checkedOther or deprecated CAS: 133163-28-7, 3092-17-9, 97476-58-9
EC numbers
255-945-3, 622-590-4
Molecular formula
C12H18N2O4
UNII
6YE7PBM15H
InChIKey
PTKSEFOSCHHMPD-UHFFFAOYSA-N
InChI
InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16)
SMILES (canonical and isomeric)
COC1=CC(=C(C=C1)OC)C(CNC(=O)CN)O

Synonyms

  • Midodrin
  • Midodrina
  • Midodrinum
  • St 1085
  • 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol
  • DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid
  • Acetamide, 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-
  • 2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamid
  • 2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethylacetamide
  • 2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide
  • Midodrinum (INN-Latin)
  • (+-)-2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide
  • 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)ethanimidic acid
  • 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]ethanimidic acid
  • 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide
  • Midodrine free base
  • Midodrine (INN)
  • (RS)-N'-(beta-Hydroxy-2,5-dimethoxy-phenethyl)glycinamid
  • 42794-76-3 (free base)
  • 2-Amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxy-ethyl]acetamide
  • DivK1c_000955
  • N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamide
  • N-{2-[2,5-bis(methyloxy)phenyl]-2-hydroxyethyl}glycinamide
  • rac-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamide
  • 2-amino-n-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-acetamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Solidexp.
Melting point
150 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
254.29 g/molcalc.
Exact mass
254.1267 Dacalc.
LogP (octanol/water)
-0.19calc.
Topological polar surface area
93.81 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
6calc.
Heavy atoms
18calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.42calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Midodrine suppliers

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All 46 suppliers
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Where suppliers are based

46 suppliers in 15 countries

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Midodrine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Adrenergic alpha-1 Receptor Agonists
  • Sympathomimetics
  • Vasoconstrictor Agents

Roles

  • adrenergic agent
  • adrenergic agonist
  • alpha-adrenergic agonist
  • alpha-adrenergic drug
  • cardiovascular drug
  • neurotransmitter agent
  • pharmaceutical
  • pro-agent
  • prodrug
  • sympathomimetic agent
  • vasoconstrictor agent

Pharmacology

Midodrine is an alpha-Adrenergic Agonist. The mechanism of action of midodrine is as an Adrenergic alpha-Agonist.

How it is made

Synthesized from hydroquinone dimethyl ether by Friedel-Crafts acylation with chloroacetyl chloride, amination to the corresponding 2-aminoacetophenone, acylation at the amino function with chloroacetyl chloride, displacement of the chloro by the azido group and finally reduction with, e.g., sodium borohydride and catalytic hydrogenation (Pd/C).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Midodrine is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Midodrine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Midodrine, based on the data on this page

What is Midodrine?

Midodrine is an aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group.

What is the CAS number of Midodrine?

The CAS registry number of Midodrine is 42794-76-3. Other or deprecated CAS numbers: 133163-28-7, 3092-17-9, 97476-58-9.

What is the molecular formula and weight of Midodrine?

The molecular formula of Midodrine is C12H18N2O4 and its molar mass is 254.29 g/mol.

What is Midodrine used for?

Use classes: Pharmaceuticals.

Is Midodrine hazardous?

Midodrine carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Midodrine?

Midodrine is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Midodrine?

CompoundList lists 46 suppliers of Midodrine in United States, China, United Kingdom, India and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Midodrine in India?

3 suppliers in India list Midodrine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Midodrine?

Suppliers quote Midodrine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Midodrine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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