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Cardiovascular and metabolic drugs

Milrinone

Also known as Milrila, Milrinona, Milrinonum

CAS 78415-72-2Formula C12H9N3OMolar mass 211.22 g/molEC 278-903-6
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 128 suppliers listed Drug substance
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Milrinone chemical structure, C12H9N3O, CAS 78415-72-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
78415-72-2
Formula
C12H9N3O
Molar mass
211.22 g/mol
EC number
278-903-6
HS code
293339
Category
Cardiovascular and metabolic drugs

What is Milrinone?

Plain description, key identifiers and synonyms

Milrinone is a member of the class of bipyridines that is 2-pyridone which is substituted at positions 3, 5, and 6 by cyano, pyrid-4-yl, and methyl groups, respectively. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. It has a role as a vasodilator agent, a cardiotonic drug, a platelet aggregation inhibitor and an EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor. It is a nitrile, a pyridone and a member of bipyridines.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
CAS number
78415-72-2 CAS number cross-checked
EC number
278-903-6
Molecular formula
C12H9N3O
UNII
JU9YAX04C7
MDL number
MFCD00133539
InChIKey
PZRHRDRVRGEVNW-UHFFFAOYSA-N
InChI
InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
SMILES (canonical and isomeric)
CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2

Synonyms

  • Milrila
  • Milrinona
  • Milrinonum
  • Win-47203-2
  • 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile
  • 6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile
  • WIN 47203
  • WIN 47,203-2
  • (3,4'-Bipyridine)-5-carbonitrile, 1,6-dihydro-2-methyl-6-oxo-
  • Corotrop
  • (3,4'-Bipyridine)-5-carbonitrile, 6-dihydro-2-methyl-6-oxo-
  • [3,4'-Bipyridine]-5-carbonitrile, 1,6-dihydro-2-methyl-6-oxo-
  • Lactate, Milrinone
  • Primacor
  • Corotrope
  • 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
  • 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carbonitrile
  • 3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone
  • 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
  • 6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile
  • 2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile
  • 1,6-Dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile
  • 1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile
  • 2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile
  • YM 018
Show all 30 synonyms
  • Milrila (TN)
  • WIN 47203-2
  • Milrinone?
  • Milrinone (Standard)
  • Tocris-1504

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
211.22 g/molcalc.
Exact mass
211.0746 Dacalc.
LogP (octanol/water)
1.62calc.
Topological polar surface area
69.54 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
16calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.08calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1ccc(-c2ccncc2)c[nH]1

O=c1ccc(-c2ccncc2)c[nH]1

2 rings, 13 atoms, the [3,4'-Bipyridin]-6(1H)-one ring system.

38 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301 + H311 + H331Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled.
  • H301Toxic if swallowed.
  • H311Toxic in contact with skin.
  • H331Toxic if inhaled.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Milrinone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 128 suppliers
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Where suppliers are based

128 suppliers in 18 countries

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Milrinone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Cardiotonic Agents
  • Phosphodiesterase 3 Inhibitors
  • Platelet Aggregation Inhibitors
  • Vasodilator Agents

Roles

  • antihypertensive agent
  • antispasmodic drug
  • cardiotonic drug
  • cardiovascular drug
  • enzyme inhibitor
  • hematologic agent
  • muscle relaxant
  • neuromuscular agent
  • pharmaceutical
  • platelet aggregation inhibitor
  • vasodilator agent

Pharmacology

Milrinone is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Milrinone is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Milrinone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Milrinone, based on the data on this page

What is Milrinone?

Milrinone is a member of the class of bipyridines that is 2-pyridone which is substituted at positions 3, 5, and 6 by cyano, pyrid-4-yl, and methyl groups, respectively. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure.

What is the CAS number of Milrinone?

The CAS registry number of Milrinone is 78415-72-2.

What is the molecular formula and weight of Milrinone?

The molecular formula of Milrinone is C12H9N3O and its molar mass is 211.22 g/mol.

What is Milrinone used for?

Use classes: Pharmaceuticals.

Is Milrinone hazardous?

Milrinone carries the GHS signal word "Danger". Main hazards: toxic if swallowed. toxic in contact with skin. toxic if inhaled, toxic if swallowed, toxic in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Milrinone?

Milrinone is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Milrinone?

CompoundList lists 128 suppliers of Milrinone in China, United States, Germany, Spain and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Milrinone in India?

4 suppliers in India list Milrinone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Milrinone?

Suppliers quote Milrinone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Milrinone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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