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Oncology and immunology drugs

Mitomycin C

Also known as Mitomycin, Mutamycin, Ametycine

CAS 50-07-7Formula C15H18N4O5Molar mass 334.33 g/molEC 200-008-6
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Serious health hazard 110 suppliers listed Drug substance
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Mitomycin C chemical structure, C15H18N4O5, CAS 50-07-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Blue-violet crystals
Melting point
>360
Solubility
SOL IN WATER, METHANOL, BUTYL ACETATE, ACETONE, AND CYCLOHEXANONE, SLIGHTLY SOL IN BENZE…
HS code
294190
Category
Oncology and immunology drugs
UN number
UN 2811
Illustrative photo, blue pigment powder in an open fibre drum in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Mitomycin C?

Plain description, key identifiers and synonyms

Mitomycin C is a mitomycin. It has a role as an alkylating agent and an antineoplastic agent. It is a conjugate acid of a mitomycin C(1-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
CAS number
50-07-7 CAS number cross-checkedOther or deprecated CAS: 1404-00-8
EC number
200-008-6
Molecular formula
C15H18N4O5
UNII
50SG953SK6
MDL number
MFCD00078109
InChIKey
NWIBSHFKIJFRCO-WUDYKRTCSA-N
InChI
InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
Canonical SMILES
COC12C(COC(N)=O)C3=C(C(=O)C(C)=C(N)C3=O)N1CC1NC12
Isomeric SMILES
CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N

Synonyms

  • Mitomycin
  • Mutamycin
  • Ametycine
  • Mitomycin-C
  • Mitocin-C
  • Ametycin
  • Mitomycinum
  • Mytomycin
  • Mytozytrex
  • Mitomycinum C
  • Mitocin C
  • Mitamycin
  • Mitosol
  • Muamycin
  • Mitomycyna C
  • 7-Amino-9alpha-methoxymitosane
  • Mito-C
  • Mitomicina
  • Mitomycine
  • Jelmyto
  • [(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
  • (1aS,8S,8aR,8bS)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
  • [(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.0^{2,7}.0^{4,6}]trideca-1(9),11-dien-8-yl]methyl carbamate
  • Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methyl-, carbamate (ester)
  • Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS,8S,8aR,8bS)-
Show all 38 synonyms
  • Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS,8S,8aR,8bS)-
  • MitocinC
  • Mutamycine
  • Mitocin
  • Mitolem
  • Mitomycine C
  • Mito-Medac
  • Mitomycin-X
  • ((4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo(7.4.0.0^(2,7).0^(4,6))trideca-1(9),11-dien-8-yl)methyl carbamate
  • ((4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo(7.4.0.02,7.04,6)trideca-1(9),11-dien-8-yl)methyl carbamate
  • (1as,8s,8ar,8bs)-6-amino-8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione
  • (1aS,8S,8aR,8bS)-6-Amino-4,7-dioxo-8a-methoxy-5-methyl-1,1a,2,8,8a,8b-hexahydroazirino(2',3':3,4)pyrrolo(1,2-a)indol-8-ylmethyl carbamate
  • Mitozytrex

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Blue-violet crystalsexp.
Melting point
>360exp.
Solubility
SOL IN WATER, METHANOL, BUTYL ACETATE, ACETONE, AND CYCLOHEXANONE, SLIGHTLY SOL IN BENZENE, ETHER, AND CARBON TETRACHLORIDE, PRACTICALLY INSOL IN PETROLEUM ETHER.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
334.33 g/molcalc.
Exact mass
334.1277 Dacalc.
LogP (octanol/water)
-1.65calc.
Topological polar surface area
146.9 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
3calc.
Heavy atoms
24calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.53calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CC(=O)C2=C1CC1C3NC3CN21

O=C1C=CC(=O)C2=C1CC1C3NC3CN21

4 rings, 15 atoms.

82 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H300Fatal if swallowed.
  • H301Toxic if swallowed.
  • H351Suspected of causing cancer.
Precautionary statements (10)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2811

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Mitomycin C suppliers

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Where suppliers are based

110 suppliers in 21 countries

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Mitomycin C price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Alkylating Agents
  • Antibiotics, Antineoplastic
  • Cross-Linking Reagents
  • Nucleic Acid Synthesis Inhibitors

Roles

  • aetiopathogenetic role
  • alkylating agent
  • antineoplastic agent
  • genotoxin
  • mutagen
  • pharmaceutical

Pharmacology

Mitomycin is an Alkylating Drug. The mechanism of action of mitomycin is as an Alkylating Activity.

How it is made

Produced by streptomyces caespitosus (griseovinaceseus).

Yamamoto, Kenkyusho, Japan pat. 2898 (1956), Kenkyusho, Brit. pat. 830,874 (1960 to Kyowa), Gourevitch et al, U.S. pat. 3,042583 (1962 to Bristol-Myers) (production of the complex)

Derived from Streptomyces

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce, Regulatory flags: Significant new use rule

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Mitomycin C is traded under.

HS 2941.90Indicative HS code

Antibiotics, other

World exports in 2024
$6.39B
+2.3% vs 2023, imports $6.97B
2019 to 2024
Top exporters
  1. China39.7%
  2. United States11.3%
  3. Switzerland * partner reported10.9%
Top importers
  1. Italy15.0%
  2. India * partner reported12.0%
  3. China8.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Mitomycin C is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Mitomycin C, based on the data on this page

What is Mitomycin C?

Mitomycin C is a mitomycin. It has a role as an alkylating agent and an antineoplastic agent. It is a conjugate acid of a mitomycin C(1-).

What is the CAS number of Mitomycin C?

The CAS registry number of Mitomycin C is 50-07-7. Other or deprecated CAS numbers: 1404-00-8.

What is the molecular formula and weight of Mitomycin C?

The molecular formula of Mitomycin C is C15H18N4O5 and its molar mass is 334.33 g/mol.

What is Mitomycin C used for?

Known uses and roles of Mitomycin C include anticancer drugs in pharmaceuticals, synthesis reagents in research and laboratory, aetiopathogenetic role, alkylating agent, antineoplastic agent and 7 more.

Is Mitomycin C hazardous?

Mitomycin C carries the GHS signal word "Danger". Main hazards: fatal if swallowed, toxic if swallowed, suspected of causing cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Mitomycin C?

Mitomycin C is usually classified under HS code 294190 (Antibiotics, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Mitomycin C?

CompoundList lists 110 suppliers of Mitomycin C in China, United States, India, Germany and 17 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Mitomycin C in India?

8 suppliers in India list Mitomycin C on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Mitomycin C?

Suppliers quote Mitomycin C on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Mitomycin C

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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