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Oncology and immunology drugs

Mitotane

Also known as Mitotan, Lysodren, Chlodithane

CAS 53-19-0Formula C14H10Cl4Molar mass 320.05 g/molEC 200-166-6
GHS signal word: Warning. Pictograms: Serious health hazard 93 suppliers listed Drug substance
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Mitotane chemical structure, C14H10Cl4, CAS 53-19-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from pentane or methanol
Melting point
77 °C
Solubility
In water, 0.10 mg/L at 25 °C
HS code
290399
Category
Oncology and immunology drugs
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Mitotane?

Plain description, key identifiers and synonyms

Mitotane is a diarylmethane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
CAS number
53-19-0 CAS number cross-checked
EC number
200-166-6
Molecular formula
C14H10Cl4
UNII
78E4J5IB5J
MDL number
MFCD00000850
InChIKey
JWBOIMRXGHLCPP-UHFFFAOYSA-N
InChI
InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
SMILES (canonical and isomeric)
C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl

Synonyms

  • Mitotan
  • Lysodren
  • Chlodithane
  • Chloditan
  • o,p'-DDD
  • 2,4'-Ddd
  • Mitotano
  • Opeprim
  • o,p'-TDE
  • 1-Chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)benzene
  • 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
  • o,p-Tde
  • Mitotanum
  • 2,4'-Dichlorodiphenyldichloroethane
  • o,p'-Dichlorodiphenyldichloroethane
  • CB 313
  • O,p'-ddd,o p'-tde
  • 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
  • (o,p)-DDD
  • 2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane
  • 1,1-Dichloro-2,2-bis(2,4'-dichlorophenyl)ethane
  • 2,2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane
  • Ethane, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)-
  • Ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro-
  • 1-chloro-4-[2,2-dichloro-1-(2-chlorophenyl)ethyl]benzene
Show all 38 synonyms
  • Khloditan
  • Mytotan
  • ortho,para-DDD
  • ortho,para DDD
  • 1-chloro-4-(2,2-dichloro-1-(2-chlorophenyl)ethyl)benzene
  • Lisodren
  • Opddd
  • 2, 4'-Dichlorodiphenyldichloroethane
  • 1, 1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
  • 2, 2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane
  • Khlodithan
  • Chlodithan
  • 1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from pentane or methanolexp.
Melting point
77 °Cexp.
Solubility
In water, 0.10 mg/L at 25 °Cexp.
Vapour pressure
1.94 × 10⁻⁶ mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
320.05 g/molcalc.
Exact mass
317.9537 Dacalc.
LogP (octanol/water)
5.93calc.
Topological polar surface area
0 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
0calc.
Rotatable bonds
3calc.
Heavy atoms
18calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.14calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Cc2ccccc2)cc1

c1ccc(Cc2ccccc2)cc1

2 rings, 13 atoms, the Diphenylmethane ring system.

8,982 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H351Suspected of causing cancer.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Mitotane suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 93 suppliers
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Where suppliers are based

93 suppliers in 14 countries

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Mitotane price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Used to induce chemical adrenalectomies in patients having adrenal cancer by reducing host levels of adrenocorticosteroids.

O,p'-DDD (Mitotane) is produced under the name Lysodren for use as a chemotherapy agent for adrenal gland cancer.

Therapeutic category: Antineoplastic.

Industries and functions

Pharmacological actions

  • Antineoplastic Agents, Hormonal

Roles

  • antineoplastic agent
  • pharmaceutical

Pharmacology

The mechanism of action of mitotane is as a Cytochrome P450 3A4 Inducer.

How it is made

/Synthesized from/ dichloroacetaldehyde and its acetals.

Constituent of commercial DDD which contains about 10% of this o,p'-isomer. Prepn from 2,2-dichloro-1-(o-chlorophenyl)ethanol with chlorobenzene in presence of H2SO4.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Mitotane is traded under.

HS 2903.99Indicative HS code

Halogenated derivatives of aromatic hydrocarbons, other

World exports in 2024
$798M
−15.8% vs 2023, imports $786M
2019 to 2024
Top exporters
  1. China51.0%
  2. United States15.9%
  3. Belgium8.6%
Top importers
  1. India * partner reported16.1%
  2. United States14.7%
  3. Germany10.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Mitotane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Mitotane, based on the data on this page

What is Mitotane?

Mitotane is a diarylmethane.

What is the CAS number of Mitotane?

The CAS registry number of Mitotane is 53-19-0.

What is the molecular formula and weight of Mitotane?

The molecular formula of Mitotane is C14H10Cl4 and its molar mass is 320.05 g/mol.

What is Mitotane used for?

Used to induce chemical adrenalectomies in patients having adrenal cancer by reducing host levels of adrenocorticosteroids. O,p'-DDD (Mitotane) is produced under the name Lysodren for use as a chemotherapy agent for adrenal gland cancer. Therapeutic category: Antineoplastic.

Is Mitotane hazardous?

Mitotane carries the GHS signal word "Warning". Main hazards: suspected of causing cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Mitotane?

Mitotane is usually classified under HS code 290399 (Halogenated derivatives of aromatic hydrocarbons, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Mitotane?

CompoundList lists 93 suppliers of Mitotane in United States, China, United Kingdom, Germany and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Mitotane in India?

1 supplier in India list Mitotane on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Mitotane?

Suppliers quote Mitotane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Mitotane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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