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Peptides

MK 0677

Also known as Ibutamoren mesylate, Crescendo, MK 677

CAS 159752-10-0Formula C28H40N4O8S2Molar mass 624.78 g/mol
14 suppliers listed Drug substance
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MK 0677 chemical structure, C28H40N4O8S2, CAS 159752-10-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
159752-10-0
Formula
C28H40N4O8S2
Molar mass
624.78 g/mol
HS code
293590
Category
Peptides

What is MK 0677?

Plain description, key identifiers and synonyms

Ibutamoren Mesylate is the mesylate salt form of ibutamoren, an orally bioavailable, small molecule, non-peptide growth hormone secretagogue (GHS). Upon administration, ibutamoren promotes the release of growth hormone (GH) from the pituitary gland, thereby increasing plasma GH levels. This may counteract GH deficiency. GH plays an important role in many biological processes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide, methanesulfonic acid
CAS number
159752-10-0 CAS number cross-checked
Molecular formula
C28H40N4O8S2
UNII
R90JB6QJ2B
MDL number
MFCD00942284
InChIKey
DUGMCDWNXXFHDE-VZYDHVRKSA-N
InChI
InChI=1S/C27H36N4O5S.CH4O3S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27;1-5(2,3)4/h4-12,22H,13-19,28H2,1-3H3,(H,29,33);1H3,(H,2,3,4)/t22-;/m1./s1
Canonical SMILES
CC(C)(N)C(=O)NC(COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12.CS(=O)(=O)O
Isomeric SMILES
CC(C)(C(=O)N[C@H](COCC1=CC=CC=C1)C(=O)N2CCC3(CC2)CN(C4=CC=CC=C34)S(=O)(=O)C)N.CS(=O)(=O)O

Synonyms

  • Ibutamoren mesylate
  • Crescendo
  • MK 677
  • Nutrobal
  • Ibutamoren mesilate
  • Ibutamoren (Mesylate)
  • Ibutamoren mesylate (MK-0677)
  • Ibutamorin, mk-677
  • (R)-2-amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidin]-1'-yl)-1-oxopropan-2-yl)-2-methylpropanamide methanesulfonate
  • 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide, methanesulfonic acid
  • Ibutamoren mesylate (USAN)
  • 2-Amino-N-((R)-2-(benzyloxy)-1-((1-(methylsulfonyl)spiro(indoline-3,4'-piperidin)-1'-yl)carbonyl)ethyl)-2-methylpropionamide monomethanesulfonate
  • L-163,191, MK-0677
  • Ibutamoren, MK-0677
  • Ibutamoren Mesylate (MK-677)
  • Ibutamoren Mesylate(MK-0677)?
  • (R)-2-amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidine]-1'-yl)-1-oxopropan-2-yl)-2-methylpropanamide methanesulfonate
  • (R)-2-amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidin]-1'-yl)-1-oxopropan-2-yl)-2-methylpropanamidemethanesulfonate
  • 1'-(2-Methylalanyl-O-benzyl-D-seryl)-1-(methylsulfonyl)-1,2-dihydrospiro[indole-3,4'-piperidine] methanesulfonate (1:1)
  • 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-(phenylmethoxy)propan-2-yl]propanamide mesylate.
  • 2-Amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-(phenylmethoxy)propan-2-yl]propanamide methanesulfonic acid
  • 2-Amino-N-((R)-2-(benzyloxy)-1-((1-(methylsulfonyl)spiro(indoline-3,4'-piperidin)-1'-yl)carbonyl)ethyl)-2-methyl-propionamide monomethanesulfonate
  • 2-Amino-N-((R)-2-(benzyloxy)-1-((1-(methylsulphonyl)spiro(indoline-3,4'-piperidin)-1'-yl)carbonyl)ethyl)-2-methylpropionamide monomethanesulphonate
  • 2-Amino-N-(2-(1,2-dihydro-1-(methylsulfonyl)spiro(3H-indole-3,4'-piperidin)-1'-yl)-2-oxo-1-((phenylmethoxy)methyl)ethyl)-2-methylpropanamide mesilate -l
  • 2-Amino-N-(2-(1,2-dihydro-1-(methylsulfonyl)spiro(3H-indole-3,4'-piperidin)-1'-yl)-2-oxo-1-((phenylmethoxy)methyl)ethyl)-2-methylpropanamide mesylate -l
Show all 26 synonyms
  • 2-amino-N-[(1R)-1-(benzyloxymethyl)-2-(1-methylsulfonylspiro[indoline-3,4'-piperidine]-1'-yl)-2-oxo-ethyl]-2-methyl-propanamide, methanesulfonic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
624.78 g/molcalc.
Exact mass
624.2288 Dacalc.
LogP (octanol/water)
1.27calc.
Topological polar surface area
176.4 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
8calc.
Heavy atoms
42calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
1calc.
Components
2calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CCOCc1ccccc1)N1CCC2(CC1)CNc1ccccc12

O=C(CCOCc1ccccc1)N1CCC2(CC1)CNc1ccccc12

4 rings, 26 atoms.

8 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

MK 0677 suppliers

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All 14 suppliers
14 of 14 offers

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Where suppliers are based

14 suppliers in 6 countries

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MK 0677 price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code MK 0677 is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for MK 0677 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about MK 0677, based on the data on this page

What is MK 0677?

Ibutamoren Mesylate is the mesylate salt form of ibutamoren, an orally bioavailable, small molecule, non-peptide growth hormone secretagogue (GHS). Upon administration, ibutamoren promotes the release of growth hormone (GH) from the pituitary gland, thereby increasing plasma GH levels. This may counteract GH deficiency.

What is the CAS number of MK 0677?

The CAS registry number of MK 0677 is 159752-10-0.

What is the molecular formula and weight of MK 0677?

The molecular formula of MK 0677 is C28H40N4O8S2 and its molar mass is 624.78 g/mol.

Is MK 0677 hazardous?

No GHS hazard classification for MK 0677 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of MK 0677?

MK 0677 is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy MK 0677?

CompoundList lists 14 suppliers of MK 0677 in China, United States, Canada, United Kingdom and 2 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy MK 0677 in India?

1 supplier in India list MK 0677 on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of MK 0677?

Suppliers quote MK 0677 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle MK 0677

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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