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Amines and amides

N-Methylformamide

Also known as Methylformamide, Formamide, N-methyl-, Monomethylformamide

CAS 123-39-7Formula C2H5NOMolar mass 59.07 g/molEC 204-624-6
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 41 suppliers listed
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N-Methylformamide chemical structure, C2H5NO, CAS 123-39-7
2D chemical structure

Key facts

What buyers check first

All properties
Physical form
Liquid
Melting point
-5.4 °C
Boiling point
180 to 185
Density
0.9961 g/cm³ @ 25 °C
Flash point
98 °C
HS code
292419
Category
Amines and amides
Illustrative photo, 25 litre white jerry cans of liquid in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is N-Methylformamide?

Plain description, key identifiers and synonyms

N-methylformamide is a member of the class of formamides having a N-methyl substituent. It is functionally related to a formamide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-methylformamide
CAS number
123-39-7 CAS number cross-checked
EC number
204-624-6
Molecular formula
C2H5NO
UNII
XPE4G7Y986
MDL number
MFCD00003280
InChIKey
ATHHXGZTWNVVOU-UHFFFAOYSA-N
InChI
InChI=1S/C2H5NO/c1-3-2-4/h2H,1H3,(H,3,4)
SMILES (canonical and isomeric)
CNC=O

Synonyms

  • Methylformamide
  • Formamide, N-methyl-
  • Monomethylformamide
  • N-Monomethylformamide
  • n-methyl-Formamide
  • EK 7011
  • Formic acid amide, N-methyl-
  • formylmethylamine
  • Formamide, N-methyl
  • N-Formylmethylamine
  • Hconhch3
  • Formamide, methyl-
  • methylimidoformic acid
  • N-Methyl-formimidic acid
  • (E)-methylimidoformic acid
  • (Z)-methylimidoformic acid
  • NMF
  • N-Methyl-formic acid-amide
  • N-Methylformamide, 99%
  • methanimidic acid, methyl-
  • N-Methyl formamide
  • n-methylcarboxamide
  • Methylformamide, Monomethylformamide, N-Methylformimidic Acid, N-Monomethylformamide, NSC 3051
  • methyl-Methanimidic acid
  • n-methyl Formic acid amide
Show all 28 synonyms
  • Formamide, N-methyl- ( )
  • 4-04-00-00170 (Beilstein Handbook Reference)
  • N-Methylformamide Solution in Methanol, 1000ug/mL

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Liquidexp.
Melting point
-5.4 °Cexp.
Boiling point
180 to 185exp.
Density
0.9961 g/cm³ @ 25 °Cexp.
Flash point
98 °Cexp.
Autoignition temperature
322.8 °Cexp.
Solubility
Miscible in waterexp.
Vapour pressure
0.253 mm Hg @ 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
59.07 g/molcalc.
Exact mass
59.0371 Dacalc.
LogP (octanol/water)
-0.64calc.
Topological polar surface area
29.1 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
1calc.
Heavy atoms
4calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H312Harmful in contact with skin.
  • H360DMay damage the unborn child.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

N-Methylformamide suppliers

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All 41 suppliers
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Where suppliers are based

41 suppliers in 8 countries

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N-Methylformamide price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

The substance is used as an intermediate in the synthesis of pesticides, extraction solvent for aromatic hydrocarbons.

In the manufacture of methyl isocyanate.

Pharmacological actions

  • Antineoplastic Agents
  • Radiation-Sensitizing Agents

Pharmacology

N-Methylformamide is a water-soluble organic solvent. As an adjuvant antineoplastic agent, N-methylformamide depletes cellular glutathione, a key molecule involved in the antioxidation of reactive oxygen species (ROS) and other free radicals, thereby enhancing ionizing radiation-induced DNA cross-linking in and terminal differentiation of tumor cells. (NCI04)

How it is made

By heating the methylamine salt, or by reaction of methylamine with methyl or ethyl formate

Methyl formate + methylamine (amide formation)

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 616-056-00-X

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: N-Methylformamide, Ref no: 746, Annex ref: II/746

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code N-Methylformamide is traded under.

HS 2924.19Indicative HS code

Acyclic amides (including acyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$2.38B
−1.7% vs 2023, imports $2.22B
2019 to 2024
Top exporters
  1. China34.7%
  2. Germany12.5%
  3. India * partner reported6.8%
Top importers
  1. United States17.5%
  2. Germany8.8%
  3. India * partner reported6.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for N-Methylformamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about N-Methylformamide, based on the data on this page

What is N-Methylformamide?

N-methylformamide is a member of the class of formamides having a N-methyl substituent. It is functionally related to a formamide.

What is the CAS number of N-Methylformamide?

The CAS registry number of N-Methylformamide is 123-39-7.

What is the molecular formula and weight of N-Methylformamide?

The molecular formula of N-Methylformamide is C2H5NO and its molar mass is 59.07 g/mol.

What is N-Methylformamide used for?

The substance is used as an intermediate in the synthesis of pesticides, extraction solvent for aromatic hydrocarbons. In the manufacture of methyl isocyanate.

Is N-Methylformamide hazardous?

N-Methylformamide carries the GHS signal word "Danger". Main hazards: harmful in contact with skin, may damage the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of N-Methylformamide?

N-Methylformamide is usually classified under HS code 292419 (Acyclic amides (including acyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy N-Methylformamide?

CompoundList lists 41 suppliers of N-Methylformamide in China, United States, Canada, France and 4 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of N-Methylformamide?

Suppliers quote N-Methylformamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle N-Methylformamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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