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Impurities and reference standards

N-Nitrosomorpholine

Also known as 4-Nitrosomorpholine, Nitrosomorpholine, Morpholine, 4-nitroso-

CAS 59-89-2Formula C4H8N2O2Molar mass 116.12 g/molEC 627-564-6
GHS signal word: Danger. Pictograms: Serious health hazard 16 suppliers listed
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N-Nitrosomorpholine chemical structure, C4H8N2O2, CAS 59-89-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Yellow crystals
Melting point
29 °C
Boiling point
224 to 224.5
Solubility
Miscible in water in all proportions
HS code
293499
Category
Impurities and reference standards
UN number
UN 2810
Illustrative photo, yellow pigment powder in an open fibre drum in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is N-Nitrosomorpholine?

Plain description, key identifiers and synonyms

N-nitrosomorpholine is a nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco. It has a role as a mutagen and a carcinogenic agent.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-nitrosomorpholine
CAS number
59-89-2 CAS number cross-checkedOther or deprecated CAS: 67587-56-8
EC number
627-564-6
Molecular formula
C4H8N2O2
UNII
3L25FO7FN7
MDL number
MFCD00039710
InChIKey
ZKXDGKXYMTYWTB-UHFFFAOYSA-N
InChI
InChI=1S/C4H8N2O2/c7-5-6-1-3-8-4-2-6/h1-4H2
SMILES (canonical and isomeric)
C1COCCN1N=O

Synonyms

  • 4-Nitrosomorpholine
  • Nitrosomorpholine
  • Morpholine, 4-nitroso-
  • NMOR
  • N-Nitrosomorpholin
  • Morpholine, N-nitroso-
  • N-Nitrosomorfolin
  • 4-Nitroso-morpholine
  • 4-Nitrosomorpholine 1.0 mg/ml in Methanol
  • Nitrosomorpholine, 4-Nitrosomorpholine, NSC 139
  • 4-Nitrosomorpholine 0.1 mg/ml in Methanol
  • Molsidomine EP Impurity B
  • N-nitroso morpholine
  • Molsidomine impurity B CRS
  • N-Nitrosomorpholine (NMOR)
  • N-Nitrosomorpholine (Standard)
  • N-Nitrosomorpholine, Molsidomine EP Impurity B
  • N-Nitrosomorpholine 100 microg/mL in Methanol
  • N-Nitrosomorpholine Solution in Methanol, 100_g/mL
  • N-Nitrosomorpholine Solution in Methanol, 1000_g/mL
  • Molsidomine impurity B, European Pharmacopoeia (EP) Reference Standard

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Yellow crystalsexp.
Melting point
29 °Cexp.
Boiling point
224 to 224.5exp.
Solubility
Miscible in water in all proportionsexp.
Vapour pressure
25 mmHgexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
116.12 g/molcalc.
Exact mass
116.0586 Dacalc.
LogP (octanol/water)
0calc.
Topological polar surface area
41.9 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
8calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1COCCN1

C1COCCN1

1 ring, 6 atoms, the Morpholine ring system.

5,994 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H341Suspected of causing genetic defects.
  • H350May cause cancer.
  • H372Causes damage to organs through prolonged or repeated exposure.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2810

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

N-Nitrosomorpholine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 16 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

16 suppliers in 7 countries

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N-Nitrosomorpholine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

N-Nitrosomorpholine is used as a research chemical.

Patents have been issued for the use of NMOR as a solvent for polyacrylonitrile ... and as a chemical intermediate in synthesis of N-aminomorpholine. It has also been found to be effective against microbial infections. No evidence was found that it has been used commercially for these purposes.

N-Nitrosomorpholine is not used commercially in the United States.

Pharmacological actions

  • Carcinogens
  • Mutagens

Roles

  • aetiopathogenetic role
  • carcinogenic agent
  • genotoxin
  • mutagen

Pharmacology

N-Nitrosomorpholine is a yellow, crystalline nitrosamine that is sensitive to light. N-Nitrosomorpholine is not used or produced commercially in the US. This substance has been found as a contaminant in rubber products, including rubber nipples for baby bottles, and is also found in several vegetables, cheeses, alcoholic beverages and fruits. N-Nitrosomorpholine is reasonably anticipated to be a human carcinogen. (NCI05)

How it is made

Reaction of sodium nitrite with a solution of morpholine in sulfuric acid, ... reaction of nitrogen trioxide with morpholine.

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 613-346-00-8

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: 4-nitrosomorpholine, Ref no: 1747, Annex ref: II/1747

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code N-Nitrosomorpholine is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for N-Nitrosomorpholine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about N-Nitrosomorpholine, based on the data on this page

What is N-Nitrosomorpholine?

N-nitrosomorpholine is a nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco. It has a role as a mutagen and a carcinogenic agent.

What is the CAS number of N-Nitrosomorpholine?

The CAS registry number of N-Nitrosomorpholine is 59-89-2. Other or deprecated CAS numbers: 67587-56-8.

What is the molecular formula and weight of N-Nitrosomorpholine?

The molecular formula of N-Nitrosomorpholine is C4H8N2O2 and its molar mass is 116.12 g/mol.

What is N-Nitrosomorpholine used for?

N-Nitrosomorpholine is used as a research chemical. Patents have been issued for the use of NMOR as a solvent for polyacrylonitrile ... and as a chemical intermediate in synthesis of N-aminomorpholine. It has also been found to be effective against microbial infections.

Is N-Nitrosomorpholine hazardous?

N-Nitrosomorpholine carries the GHS signal word "Danger". Main hazards: suspected of causing genetic defects, may cause cancer, causes damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of N-Nitrosomorpholine?

N-Nitrosomorpholine is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy N-Nitrosomorpholine?

CompoundList lists 16 suppliers of N-Nitrosomorpholine in China, United States, India, Switzerland and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy N-Nitrosomorpholine in India?

2 suppliers in India list N-Nitrosomorpholine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of N-Nitrosomorpholine?

Suppliers quote N-Nitrosomorpholine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle N-Nitrosomorpholine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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