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Respiratory, allergy and digestive drugs

Naphazoline

Also known as 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole, Nafazolina, Clearine

CAS 835-31-4Formula C14H14N2Molar mass 210.28 g/molEC 212-641-5
61 suppliers listed Drug substance
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Naphazoline chemical structure, C14H14N2, CAS 835-31-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
835-31-4
Formula
C14H14N2
Molar mass
210.28 g/mol
EC number
212-641-5
HS code
293329
Category
Respiratory, allergy and digestive drugs

What is Naphazoline?

Plain description, key identifiers and synonyms

2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole is a member of naphthalenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
CAS number
835-31-4 CAS number cross-checkedOther or deprecated CAS: 10061-11-7
EC numbers
212-641-5, 233-197-9
Molecular formula
C14H14N2
UNII
H231GF11BV
MDL number
MFCD00066737
InChIKey
CNIIGCLFLJGOGP-UHFFFAOYSA-N
InChI
InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)
SMILES (canonical and isomeric)
C1CN=C(N1)CC2=CC=CC3=CC=CC=C32

Synonyms

  • 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
  • Nafazolina
  • Clearine
  • Nafazolin
  • Naphazolinum
  • 2-(1-Naphthylmethyl)-2-imidazoline
  • Ciba 2020/R
  • alpha-Naphthylmethyl imidazoline
  • 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-
  • Tele Stulln
  • AK Con
  • Vasoconstrictor Pensa
  • Pensa, Vasoconstrictor
  • naphthizinum (for the nitrate)
  • Naphthizine
  • Antan
  • 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole
  • 2-(Naphthyl-(1')-methyl)imidazolin
  • Naphazoline (INN)
  • 2-Imidazoline, 2-(1-naphthylmethyl)-
  • 2-[(naphthalen-1-yl)methyl]-4,5-dihydro-1H-imidazole
  • Naphazoline (hydrochloride)
  • Naphcon
  • Nafazoline
  • Rhinazine
Show all 30 synonyms
  • 2-(alpha-Naphthylmethyl)-imidazoline
  • 4,5-Dihydro-2-(1-naphthylmethyl)imidazole
  • Imidin
  • Privine (Salt/Mix)
  • Sanorin (Salt/Mix)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
210.28 g/molcalc.
Exact mass
210.1157 Dacalc.
LogP (octanol/water)
2.38calc.
Topological polar surface area
24.39 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
2calc.
Heavy atoms
16calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.21calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(CC3=NCCN3)cccc2c1

c1ccc2c(CC3=NCCN3)cccc2c1

3 rings, 16 atoms. This chemical is the scaffold itself.

13 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Naphazoline suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 61 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

61 suppliers in 18 countries

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Naphazoline price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Adrenergic alpha-Agonists
  • Nasal Decongestants

Pharmacology

Naphazoline is an imidazole derivative and a direct-acting sympathomimetic amine with vasoconstrictive activity. Upon ocular administration, naphazoline exerts its effect by acting on alpha-adrenergic receptors in the arterioles of the conjunctiva to produce vasoconstriction, resulting in decreased conjunctival congestion and diminished itching, irritation and redness.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Naphazoline (INN) and its salts, Ref no: 244, Annex ref: II/244
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Naphazoline is traded under.

HS 2933.29Indicative HS code

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…

World exports in 2024
$1.43B
−7.6% vs 2023, imports $1.47B
2019 to 2024
Top exporters
  1. China28.1%
  2. France * partner reported12.7%
  3. India * partner reported10.3%
Top importers
  1. United Kingdom13.0%
  2. United States7.9%
  3. China6.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Naphazoline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Naphazoline, based on the data on this page

What is Naphazoline?

2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole is a member of naphthalenes.

What is the CAS number of Naphazoline?

The CAS registry number of Naphazoline is 835-31-4. Other or deprecated CAS numbers: 10061-11-7.

What is the molecular formula and weight of Naphazoline?

The molecular formula of Naphazoline is C14H14N2 and its molar mass is 210.28 g/mol.

What is Naphazoline used for?

Use classes: Pharmaceuticals.

Is Naphazoline hazardous?

No GHS hazard classification for Naphazoline is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Naphazoline?

Naphazoline is usually classified under HS code 293329 (Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Naphazoline?

CompoundList lists 61 suppliers of Naphazoline in United States, China, United Kingdom, Spain and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Naphazoline in India?

2 suppliers in India list Naphazoline on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Naphazoline?

Suppliers quote Naphazoline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Naphazoline

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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