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Antibiotics and anti-infectives

Niclosamide

Also known as 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, Niclocide, Tredemine

CAS 50-65-7Formula C13H8Cl2N2O4Molar mass 327.12 g/molEC 200-056-8
GHS signal word: Warning. Pictograms: Hazardous to the environment 127 suppliers listed
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Niclosamide chemical structure, C13H8Cl2N2O4, CAS 50-65-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Pale, yellow crystals
Melting point
225 to 230
Solubility
In water = 5-8 mg/L at 20 °C
HS code
292429
Category
Antibiotics and anti-infectives
Illustrative photo, yellow pigment powder in a glass jar on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Niclosamide?

Plain description, key identifiers and synonyms

Niclosamide is a secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections. It has a role as an anticoronaviral agent, a piscicide, a molluscicide, an antiparasitic agent, an anthelminthic drug, an apoptosis inducer and a STAT3 inhibitor. It is a secondary carboxamide, a member of benzamides, a C-nitro compound, a member of salicylanilides and a member of monochlorobenzenes. It is functionally related to a 5-chlorosalicylic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
CAS number
50-65-7 CAS number cross-checked
EC number
200-056-8
Molecular formula
C13H8Cl2N2O4
UNII
8KK8CQ2K8G
MDL number
MFCD00057597
InChIKey
RJMUSRYZPJIFPJ-UHFFFAOYSA-N
InChI
InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
SMILES (canonical and isomeric)
C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O

Synonyms

  • 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
  • Niclocide
  • Tredemine
  • Cestocid
  • Fenasal
  • Mansonil
  • Phenasal
  • Vermitid
  • Yomesan
  • Lintex
  • Nasemo
  • Sulqui
  • Devermin
  • Devermine
  • Helmiantin
  • Radeverm
  • Iomesan
  • Sagimid
  • Mato
  • Fedal-Telmin
  • Zestocarp
  • Atenase
  • Iomezan
  • Bayer 2353
  • Bayer 73
Show all 39 synonyms
  • Niclosamida
  • BAY 2353
  • Chemagro 2353
  • Niclosamidum
  • 5-Chloro-2'-chloro-4'-nitrosalicylanilide
  • HL 2447
  • WR 46234
  • Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-
  • Nitrophenyl chlorsalicylamide
  • 2-Hydroxy-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide
  • N-(2-Chloro-4-nitrophenyl)-5-chlorosalicylamide
  • Salicylanilide, 2',5-dichloro-4'-nitro-
  • 2-Chloro-4-nitrophenylamide-6-chlorosalicylic acid
  • Niclosamide, anhydrous

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Pale, yellow crystalsexp.
Taste
Tastelessexp.
Melting point
225 to 230exp.
Solubility
In water = 5-8 mg/L at 20 °Cexp.
Vapour pressure
<9.87 × 10⁻⁹ mm Hg at 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
327.12 g/molcalc.
Exact mass
325.9861 Dacalc.
LogP (octanol/water)
3.86calc.
Topological polar surface area
92.47 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
3calc.
Heavy atoms
21calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1ccccc1)c1ccccc1

O=C(Nc1ccccc1)c1ccccc1

2 rings, 15 atoms, the Benzanilide ring system.

13,118 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (3)
  • P273Avoid release to the environment.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Niclosamide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 127 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

127 suppliers in 19 countries

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Niclosamide price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Molluscicide (ethanolamine salt).

Molluscicide with respiratory and stomach action, control of schistosomiasis and fascioliasis in man by control of fresh-water snails which act as intermediate hosts.

Pharmacological actions

  • Anticestodal Agents
  • Antinematodal Agents
  • Molluscacides

Roles

  • STAT3 inhibitor
  • anthelminthic drug
  • anticoronaviral agent
  • antiinfective agent
  • antimicrobial agent
  • antiparasitic agent
  • antirheumatic drug
  • antiviral agent
  • apoptosis inducer
  • hypoglycemic agent
  • molluscicide
  • pesticide
  • pharmaceutical
  • piscicide

Pharmacology

Niclosamide is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Upon oral administration, niclosamide specifically induces degradation of the androgen receptor (AR) variant V7 (AR-V7) through the proteasome-mediated pathway. This downregulates the expression of the AR variant, inhibits AR-V7-mediated transcriptional activity, and reduces AR-V7 recruitment to the prostate-specific antigen (PSA) gene promoter. Niclosamide also prevents AR-V7-mediated STAT3 phosphorylation and activation.

Read more

This inhibits AR/STAT3-mediated signaling and prevents expression of STAT3 target genes. Altogether, this may inhibit growth of AR-V7-overexpressing cancer cells. The AR-V7 variant, which is encoded by contiguous splicing of AR exons 1/2/3/CE3, is upregulated in a variety of cancer cell types, and is associated with both cancer progression and resistance to AR-targeted therapies.

How it is made

Phosphorus trichloride is slowly introduced into a boiling xylene solution containing 5-chlorosalicylic acid & 2-chloro-4-nitroaniline in equimolar ratio & heating continued for 3 hr. Crystals of niclosamide separate on cooling & are recrystallized from ethanol.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Niclosamide is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Niclosamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Niclosamide, based on the data on this page

What is Niclosamide?

Niclosamide is a secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.

What is the CAS number of Niclosamide?

The CAS registry number of Niclosamide is 50-65-7.

What is the molecular formula and weight of Niclosamide?

The molecular formula of Niclosamide is C13H8Cl2N2O4 and its molar mass is 327.12 g/mol.

What is Niclosamide used for?

Veterinary medication:. Molluscicide (ethanolamine salt). Molluscicide with respiratory and stomach action, control of schistosomiasis and fascioliasis in man by control of fresh-water snails which act as intermediate hosts.

Is Niclosamide hazardous?

Niclosamide carries the GHS signal word "Warning". Main hazards: very toxic to aquatic life, very toxic to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Niclosamide?

Niclosamide is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Niclosamide?

CompoundList lists 127 suppliers of Niclosamide in China, United States, India, United Kingdom and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Niclosamide in India?

18 suppliers in India list Niclosamide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Niclosamide?

Suppliers quote Niclosamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Niclosamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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