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Oncology and immunology drugs

Niraparib

Also known as 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide, 2-{4-[(3s)-piperidin-3-yl]phenyl}-2h-indazole-7-carboxamide, niraparibum

CAS 1038915-60-4Formula C19H20N4OMolar mass 320.40 g/molEC 685-112-3
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 50 suppliers listed Drug substance
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Niraparib chemical structure, C19H20N4O, CAS 1038915-60-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1038915-60-4
Formula
C19H20N4O
Molar mass
320.40 g/mol
EC number
685-112-3
HS code
293339
Category
Oncology and immunology drugs

What is Niraparib?

Plain description, key identifiers and synonyms

Niraparib is a 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy. It has a role as a radiosensitizing agent, an antineoplastic agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and an apoptosis inducer.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide
CAS number
1038915-60-4 CAS number cross-checked
EC number
685-112-3
Molecular formula
C19H20N4O
UNII
HMC2H89N35
MDL number
MFCD17779309
InChIKey
PCHKPVIQAHNQLW-CQSZACIVSA-N
InChI
InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1
Canonical SMILES
NC(=O)c1cccc2cn(-c3ccc(C4CCCNC4)cc3)nc12
Isomeric SMILES
C1C[C@H](CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N

Synonyms

  • 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide
  • 2-{4-[(3s)-piperidin-3-yl]phenyl}-2h-indazole-7-carboxamide
  • niraparibum
  • 2-(4-((3S)-piperidin-3-yl)phenyl)indazole-7-carboxamide
  • 2-(4-((3S)-Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide
  • (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide
  • 2-[4-(3S)-3-Piperidinylphenyl]-2H-indazole-7-carboxamide
  • MK-4827 (Niraparib)
  • Niraparib (USAN)
  • 2-[4-[(3S)-3-Piperidyl]phenyl]indazole-7-carboxamide
  • 2H-Indazole-7-carboxamide, 2-[4-(3S)-3-piperidinylphenyl]-
  • Niraparib (MK-4827)
  • MK 4827 (Base)
  • (S)-2-[4-(Piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide
  • 2H-Indazole-7-carboxamide, 2-(4-(3S)-3-piperidinylphenyl)-
  • Niraparib (Standard)
  • (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide, MK-4827
  • Niraparib(MK4827) free base?
  • MK-4827 (PARP-1)
  • compound 56
  • Akeega (niraparib and abiraterone acetate)
  • (S)-2(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide
  • 2H-Indazole-7-carboxamide, 2-[4-(3S)-3-piperidinylphenyl]

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
320.40 g/molcalc.
Exact mass
320.1637 Dacalc.
LogP (octanol/water)
2.59calc.
Topological polar surface area
72.94 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
24calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.26calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2nn(-c3ccc(C4CCCNC4)cc3)cc2c1

c1ccc2nn(-c3ccc(C4CCCNC4)cc3)cc2c1

4 rings, 21 atoms.

22 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H340May cause genetic defects.
  • H361Suspected of damaging fertility or the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (11)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Niraparib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 50 suppliers
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Where suppliers are based

50 suppliers in 11 countries

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Niraparib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Poly(ADP-ribose) Polymerase Inhibitors

Roles

  • antineoplastic agent
  • apoptosis inducer
  • enzyme inhibitor
  • pharmaceutical
  • radiosensitizing agent

Pharmacology

Niraparib is a Poly(ADP-Ribose) Polymerase Inhibitor. The mechanism of action of niraparib is as a Poly(ADP-Ribose) Polymerase Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Niraparib is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Niraparib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Niraparib, based on the data on this page

What is Niraparib?

Niraparib is a 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy.

What is the CAS number of Niraparib?

The CAS registry number of Niraparib is 1038915-60-4.

What is the molecular formula and weight of Niraparib?

The molecular formula of Niraparib is C19H20N4O and its molar mass is 320.40 g/mol.

What is Niraparib used for?

Known uses and roles of Niraparib include anticancer drugs in pharmaceuticals, antineoplastic agent, apoptosis inducer, enzyme inhibitor, pharmaceutical and 2 more.

Is Niraparib hazardous?

Niraparib carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may cause genetic defects, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Niraparib?

Niraparib is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Niraparib?

CompoundList lists 50 suppliers of Niraparib in China, United States, United Kingdom, Canada and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Niraparib in India?

1 supplier in India list Niraparib on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Niraparib?

Suppliers quote Niraparib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Niraparib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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