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Impurities and reference standards

o-Vanillin

Also known as 2-Hydroxy-3-methoxybenzaldehyde, 2-Vanillin, 6-Formylguaiacol

CAS 148-53-8Formula C8H8O3Molar mass 152.15 g/molEC 205-715-3
GHS signal word: Danger. Pictograms: Corrosive, Harmful or irritant 28 suppliers listed
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o-Vanillin chemical structure, C8H8O3, CAS 148-53-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
148-53-8
Formula
C8H8O3
Molar mass
152.15 g/mol
EC number
205-715-3
HS code
291249
Category
Impurities and reference standards

What is o-Vanillin?

Plain description, key identifiers and synonyms

Ortho-vanillin is a member of the class of benzaldehydes that is salicylaldehyde substituted by a methoxy group at position 3. It has a role as an antimutagen and a plant metabolite. It is a member of guaiacols and a member of benzaldehydes. It is functionally related to a salicylaldehyde.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-hydroxy-3-methoxybenzaldehyde
CAS number
148-53-8 CAS number cross-checked
EC number
205-715-3
Molecular formula
C8H8O3
UNII
008LR748FI
MDL number
MFCD00003322
InChIKey
JJVNINGBHGBWJH-UHFFFAOYSA-N
InChI
InChI=1S/C8H8O3/c1-11-7-4-2-3-6(5-9)8(7)10/h2-5,10H,1H3
SMILES (canonical and isomeric)
COC1=CC=CC(=C1O)C=O

Synonyms

  • 2-Hydroxy-3-methoxybenzaldehyde
  • 2-Vanillin
  • 6-Formylguaiacol
  • Orthovanilline
  • Benzaldehyde, 2-hydroxy-3-methoxy-
  • 6-Formyl-2-methoxyphenol
  • 3-Methoxy-2-hydroxybenzaldehyde
  • m-Anisaldehyde, 2-hydroxy-
  • Oxy-2 methoxy-3 benzaldehyde
  • o-vanilin
  • 3-Methoxysalicylaldehyde
  • ortho-vanillin
  • 2-Hydroxy-m-anisaldehyde
  • o-Vanilline
  • 2-Hydroxy-3-methoxy-benzaldehyde
  • Ortho vanillin
  • Entacapone Impurity 63
  • 2-hydroxy-3-(methyloxy)benzaldehyde
  • 2-hydroxy-3-methoxy benzaldehyde
  • US8614253, .3-63
  • Benzalde
  • o-vaniline
  • 0-vanillin
  • o-Vanillin, 99%
  • Entacapone Impurity 30
Show all 35 synonyms
  • 2-hydroxy-3 methoxybenzaldehyde
  • 3-methoxy-2-hydroxy-benzaldehyde
  • 2-Hydroxyl-3-methoxybenzaldehyde
  • 2-Hydroxy-3-methoxybenzaldehyde o-Vanillin
  • Hydroxy-3-methoxybenzaldehyde, 2-
  • 2-Hydroxy-3-methoxybenzaldehyde (NIST) negative
  • 2-Hydroxy-3-methoxybenzaldehyde (NIST) positive
  • US8614253, .3-55
  • 2-Hydroxy,3-methoxy-benzaldehyde (O-vanillin)
  • 3-Methoxysalicylaldehyde(Discontinued,See C4X-162930)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
152.15 g/molcalc.
Exact mass
152.0473 Dacalc.
LogP (octanol/water)
1.21calc.
Topological polar surface area
46.53 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
11calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.13calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H317May cause an allergic skin reaction.
  • H318Causes serious eye damage.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (23)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

o-Vanillin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 28 suppliers
28 of 28 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

28 suppliers in 7 countries

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o-Vanillin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antimutagen
  • eukaryotic metabolite
  • metabolite
  • plant metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code o-Vanillin is traded under.

HS 2912.49Indicative HS code

Aldehyde-alcohols, aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen…

World exports in 2024
$159M
−9.6% vs 2023, imports $171M
2019 to 2024
Top exporters
  1. China36.7%
  2. India * partner reported27.5%
  3. Germany13.9%
Top importers
  1. China16.0%
  2. United States15.7%
  3. India * partner reported9.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for o-Vanillin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about o-Vanillin, based on the data on this page

What is o-Vanillin?

Ortho-vanillin is a member of the class of benzaldehydes that is salicylaldehyde substituted by a methoxy group at position 3. It has a role as an antimutagen and a plant metabolite. It is a member of guaiacols and a member of benzaldehydes. It is functionally related to a salicylaldehyde.

What is the CAS number of o-Vanillin?

The CAS registry number of o-Vanillin is 148-53-8.

What is the molecular formula and weight of o-Vanillin?

The molecular formula of o-Vanillin is C8H8O3 and its molar mass is 152.15 g/mol.

What is o-Vanillin used for?

Known uses and roles of o-Vanillin include antimutagen, eukaryotic metabolite, metabolite and plant metabolite.

Is o-Vanillin hazardous?

o-Vanillin carries the GHS signal word "Danger". Main hazards: harmful if swallowed, causes skin irritation, may cause an allergic skin reaction. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of o-Vanillin?

o-Vanillin is usually classified under HS code 291249 (Aldehyde-alcohols, aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy o-Vanillin?

CompoundList lists 28 suppliers of o-Vanillin in China, United States, Canada, Czech Republic and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of o-Vanillin?

Suppliers quote o-Vanillin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle o-Vanillin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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