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Screening compounds

Ono-7475

Also known as tamnorzatinib, N-(5-((6,7-Dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide, N-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-2,5-dioxo-1-phenyl-7,8-dihydro-6H-quinoline-3-carboxamide

CAS 1646839-59-9Formula C32H26N4O6Molar mass 562.58 g/mol
1 supplier listed
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Ono-7475 chemical structure, C32H26N4O6, CAS 1646839-59-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1646839-59-9
Formula
C32H26N4O6
Molar mass
562.58 g/mol
HS code
293349
Category
Screening compounds

What is Ono-7475?

Plain description, key identifiers and synonyms

Tamnorzatinib is an orally available and selective inhibitor of the receptor tyrosine kinases (RTKs) Axl (UFO) and Mer, with potential antineoplastic activity. Upon administration, tamnorzatinib targets and binds to both Axl and Mer, and prevents their activity. This blocks Axl- and Mer-mediated signal transduction pathways, and inhibits proliferation and migration of Axl- and Mer-overexpressing tumor cells. Axl and Mer, both members of the TAM (Tyro3, Axl and Mer) family of RTKs, are overexpressed by many tumor cell types. They play key roles in tumor cell proliferation, survival, invasion, angiogenesis and metastasis, and their expression is associated with drug resistance and poor prognosis.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[5-(6,7-dimethoxyquinolin-4-yl)oxy-2-pyridinyl]-2,5-dioxo-1-phenyl-7,8-dihydro-6H-quinoline-3-carboxamide
CAS number
1646839-59-9
Molecular formula
C32H26N4O6
UNII
0VCB95RHRV
MDL number
MFCD32689448
InChIKey
WHMMKPWGWNYYFE-UHFFFAOYSA-N
InChI
InChI=1S/C32H26N4O6/c1-40-28-16-21-24(17-29(28)41-2)33-14-13-27(21)42-20-11-12-30(34-18-20)35-31(38)23-15-22-25(9-6-10-26(22)37)36(32(23)39)19-7-4-3-5-8-19/h3-5,7-8,11-18H,6,9-10H2,1-2H3,(H,34,35,38)
SMILES (canonical and isomeric)
COC1=CC2=C(C=CN=C2C=C1OC)OC3=CN=C(C=C3)NC(=O)C4=CC5=C(CCCC5=O)N(C4=O)C6=CC=CC=C6

Synonyms

  • tamnorzatinib
  • N-(5-((6,7-Dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide
  • N-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-2,5-dioxo-1-phenyl-7,8-dihydro-6H-quinoline-3-carboxamide
  • 3-Quinolinecarboxamide, N-(5-((6,7-dimethoxy-4-quinolinyl)oxy)-2-pyridinyl)-1,2,5,6,7,8-hexahydro-2,5-dioxo-1-phenyl-
  • N-(5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl)-2,5-dioxo-1-phenyl-7,8-dihydro-6H-quinoline-3-carboxamide
  • Axl/Mer Inhibitor ONO-7475
  • Axl/Mer RTK Inhibitor ONO-7475
  • Ono 7475
  • N-[5-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1,2,5,6,7,8-hexahydro-2,5-dioxo-1-phenyl-3-quinolinecarboxamide
  • N-[5-(6,7-dimethoxyquinolin-4-yl)oxy-2-pyridinyl]-2,5-dioxo-1-phenyl-7,8-dihydro-6H-quinoline-3-carboxamide
  • Tamnorzatinib (ONO-7475)
  • ONO-7475?
  • N-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-2,5-dioxo-1-phenyl-7,8-dihydro-6H-
  • N-[5-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-pyridyl]-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide
  • N-[5-[(6,7-dimethoxy-4-quinolyl)oxy]-2-pyridyl]-2,5-dioxo-1-phenyl-7,8-dihydro-6H-quinoline-3-carboxamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
562.58 g/molcalc.
Exact mass
562.1852 Dacalc.
LogP (octanol/water)
5.36calc.
Topological polar surface area
121.6 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
7calc.
Heavy atoms
42calc.
Rings
6calc.
Aromatic rings
5calc.
Fraction sp3 carbons
0.16calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCCc2c1cc(C(=O)Nc1ccc(Oc3ccnc4ccccc34)cn1)c(=O)n2-c1ccccc1

O=C1CCCc2c1cc(C(=O)Nc1ccc(Oc3ccnc4ccccc34)cn1)c(=O)n2-c1ccccc1

6 rings, 38 atoms.

No other chemical in our database has this scaffold.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Ono-7475 suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

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  • Ureiko
    ChinaUnclaimed profile
    Ono-7475Grade, purity and minimum order on request
    Price on request
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Where suppliers are based

1 supplier in 1 country

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Ono-7475 price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ono-7475 is traded under.

HS 2933.49Indicative HS code

Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…

World exports in 2024
$939M
−14.6% vs 2023, imports $1.48B
2019 to 2024
Top exporters
  1. China30.1%
  2. India * partner reported16.7%
  3. Switzerland * partner reported14.1%
Top importers
  1. United Kingdom19.2%
  2. Germany16.0%
  3. Romania8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ono-7475 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ono-7475, based on the data on this page

What is Ono-7475?

Tamnorzatinib is an orally available and selective inhibitor of the receptor tyrosine kinases (RTKs) Axl (UFO) and Mer, with potential antineoplastic activity. Upon administration, tamnorzatinib targets and binds to both Axl and Mer, and prevents their activity.

What is the CAS number of Ono-7475?

The CAS registry number of Ono-7475 is 1646839-59-9.

What is the molecular formula and weight of Ono-7475?

The molecular formula of Ono-7475 is C32H26N4O6 and its molar mass is 562.58 g/mol.

What is Ono-7475 used for?

Known uses and roles of Ono-7475 include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Ono-7475 hazardous?

No GHS hazard classification for Ono-7475 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Ono-7475?

Ono-7475 is usually classified under HS code 293349 (Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ono-7475?

CompoundList lists 1 supplier of Ono-7475 in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Ono-7475?

Suppliers quote Ono-7475 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ono-7475

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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