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Screening compounds

Opaganib

Also known as 3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide, ABC 294640, Yeliva

CAS 915385-81-8Formula C23H25ClN2OMolar mass 380.92 g/mol
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Opaganib chemical structure, C23H25ClN2O, CAS 915385-81-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
915385-81-8
Formula
C23H25ClN2O
Molar mass
380.92 g/mol
HS code
293339
Category
Screening compounds

What is Opaganib?

Plain description, key identifiers and synonyms

3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)-1-adamantanecarboxamide is an organochlorine compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide
CAS number
915385-81-8
Molecular formula
C23H25ClN2O
UNII
DRG21OQ517
MDL number
MFCD22666355
InChIKey
CAOTVXGYTWCKQE-UHFFFAOYSA-N
InChI
InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27)
SMILES (canonical and isomeric)
C1C2CC3(CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4)C5=CC=C(C=C5)Cl

Synonyms

  • 3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide
  • ABC 294640
  • Yeliva
  • 4-pyridinylmethyl-3-(4-chlorophenyl) adamantane carboxamide
  • 4-Pyridinylmethyl 3(4-chlorophenyl)adamantine carboxamide
  • Tricyclo(3.3.1.13,7)decane-1-carboxamide, 3-(4-chlorophenyl)-N-(4-pyridinylmethyl)-
  • opaganibum
  • 3-(4-chlorophenyl)-N-((pyridin-4-yl)methyl)adamantane-1-carboxamide
  • 3-(4-chlorophenyl)-N-[(pyridin-4-yl)methyl]adamantane-1-carboxamide
  • SK2 inhibitor ABC294640
  • Opaganib (ABC294640)
  • 3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.13,7]decane-1-carboxamide
  • (1s,3r,5R,7S)-3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide
  • ABC294640Opaganib?
  • 3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.1(3,7)]decane-1-carboxamide
  • 3-(4-chlorophenyl)-N-(4-pyridylmethyl)adamantane-1-carboxamide
  • ABC294640|915385-81-8|ABC-294640

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
380.92 g/molcalc.
Exact mass
380.1655 Dacalc.
LogP (octanol/water)
4.89calc.
Topological polar surface area
41.99 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
4calc.
Heavy atoms
27calc.
Rings
6calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.48calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(NCc1ccncc1)C12CC3CC(C1)CC(c1ccccc1)(C3)C2

O=C(NCc1ccncc1)C12CC3CC(C1)CC(c1ccccc1)(C3)C2

6 rings, 26 atoms.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Opaganib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 4 suppliers
4 of 4 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

4 suppliers in 3 countries

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Opaganib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Pharmacology

Opaganib is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, opaganib competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis and may result in an inhibition of cell proliferation in cancer cells overexpressing SK2. SK2 and its isoenzyme SK1 are overexpressed in numerous cancer cell types.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Opaganib is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Opaganib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Opaganib, based on the data on this page

What is Opaganib?

3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)-1-adamantanecarboxamide is an organochlorine compound.

What is the CAS number of Opaganib?

The CAS registry number of Opaganib is 915385-81-8.

What is the molecular formula and weight of Opaganib?

The molecular formula of Opaganib is C23H25ClN2O and its molar mass is 380.92 g/mol.

What is Opaganib used for?

Known uses and roles of Opaganib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Opaganib hazardous?

No GHS hazard classification for Opaganib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Opaganib?

Opaganib is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Opaganib?

CompoundList lists 4 suppliers of Opaganib in China, Canada and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Opaganib?

Suppliers quote Opaganib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Opaganib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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