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Oprozomib

Also known as ONX 0912, (2S)-3-methoxy-2-[(2S)-3-methoxy-2-[(2-methyl-1,3-thiazol-5-yl)formamido]propanamido]-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]propanamide, oprozomibum

CAS 935888-69-0Formula C25H32N4O7SMolar mass 532.62 g/mol
4 suppliers listed
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Oprozomib chemical structure, C25H32N4O7S, CAS 935888-69-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
935888-69-0
Formula
C25H32N4O7S
Molar mass
532.62 g/mol
HS code
293410
Category
Peptides

What is Oprozomib?

Plain description, key identifiers and synonyms

Oprozomib is an orally bioavailable proteasome inhibitor with potential antineoplastic activity. Proteasome inhibitor ONX 0912 inhibits the activity of the proteasome, thereby blocking the targeted proteolysis normally performed by the proteasome, this may result in an accumulation of unwanted or misfolded proteins. Disruption of various cell signaling pathways may follow, eventually leading to the induction of apoptosis and inhibition of tumor growth. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquitinated.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[(2S)-3-methoxy-1-[[(2S)-3-methoxy-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
CAS number
935888-69-0 CAS number cross-checked
Molecular formula
C25H32N4O7S
UNII
MZ37792Y8J
MDL number
MFCD25976563
InChIKey
SWZXEVABPLUDIO-WSZYKNRRSA-N
InChI
InChI=1S/C25H32N4O7S/c1-15-26-11-20(37-15)24(33)29-19(13-35-4)23(32)28-18(12-34-3)22(31)27-17(21(30)25(2)14-36-25)10-16-8-6-5-7-9-16/h5-9,11,17-19H,10,12-14H2,1-4H3,(H,27,31)(H,28,32)(H,29,33)/t17-,18-,19-,25+/m0/s1
Canonical SMILES
COCC(NC(=O)c1cnc(C)s1)C(=O)NC(COC)C(=O)NC(Cc1ccccc1)C(=O)C1(C)CO1
Isomeric SMILES
CC1=NC=C(S1)C(=O)N[C@@H](COC)C(=O)N[C@@H](COC)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)[C@]3(CO3)C

Synonyms

  • ONX 0912
  • (2S)-3-methoxy-2-[(2S)-3-methoxy-2-[(2-methyl-1,3-thiazol-5-yl)formamido]propanamido]-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]propanamide
  • oprozomibum
  • (2S)-3-methoxy-2-((2S)-3-methoxy-2-((2-methyl-1,3-thiazol-5-yl)formamido)propanamido)-N-((2S)-1-((2R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)propanamide
  • Proteasome Inhibitor ONX 0912
  • O-Methyl-N-((2-methylthiazol-5-yl)carbonyl)-L-seryl-O-methyl-N-((1S)-1-benzyl-2-((2R)-2-methyloxiran-2-yl)-2-oxoethyl)-L-serinamide
  • Oprozomib (ONX 0912)
  • PR 047
  • O-Methyl-N-((2-methylthiazol-5-yl)carbonyl)-L-seryl-O-methyl-N-((1S)-1-benzyl-2-((2R)- 2-methyloxiran-2-yl)-2-oxoethyl)-L-serinamide
  • Oprozomib (ONX-0912)
  • Onx0912(oprozomib)
  • Oprozomib (USAN/INN)
  • Oprozomib (ONX-0912)?
  • L-Serinamide, O-methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-
  • L-Serinamide, O-methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-
  • L-Serinamide, O-methyl-N-((2-methyl-5-thiazolyl)carbonyl)-L-seryl-O-methyl-N-((1S)-2- ((2R)-2-methyl-2-oxiranyl)-2-oxo-1-(phenylmethyl)ethyl)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
532.62 g/molcalc.
Exact mass
532.1992 Dacalc.
LogP (octanol/water)
0.41calc.
Topological polar surface area
148.3 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
9calc.
Rotatable bonds
14calc.
Heavy atoms
37calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.48calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CNC(=O)c1cncs1)NCC(=O)NC(Cc1ccccc1)C(=O)C1CO1

O=C(CNC(=O)c1cncs1)NCC(=O)NC(Cc1ccccc1)C(=O)C1CO1

3 rings, 29 atoms.

1 other chemical share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Oprozomib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 4 suppliers
4 of 4 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

4 suppliers in 2 countries

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Oprozomib price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • angiogenesis inhibitor
  • antineoplastic agent
  • apoptosis inducer
  • pharmaceutical
  • proteasome inhibitor

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Oprozomib is traded under.

HS 2934.10Indicative HS code

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…

World exports in 2024
$3.88B
−16.1% vs 2023, imports $3.12B
2019 to 2024
Top exporters
  1. Switzerland * partner reported36.4%
  2. Ireland28.8%
  3. China10.0%
Top importers
  1. Canada33.4%
  2. United States14.4%
  3. Ireland13.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Oprozomib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Oprozomib, based on the data on this page

What is Oprozomib?

Oprozomib is an orally bioavailable proteasome inhibitor with potential antineoplastic activity. Proteasome inhibitor ONX 0912 inhibits the activity of the proteasome, thereby blocking the targeted proteolysis normally performed by the proteasome, this may result in an accumulation of unwanted or misfolded proteins.

What is the CAS number of Oprozomib?

The CAS registry number of Oprozomib is 935888-69-0.

What is the molecular formula and weight of Oprozomib?

The molecular formula of Oprozomib is C25H32N4O7S and its molar mass is 532.62 g/mol.

What is Oprozomib used for?

Known uses and roles of Oprozomib include angiogenesis inhibitor, antineoplastic agent, apoptosis inducer, pharmaceutical and proteasome inhibitor.

Is Oprozomib hazardous?

No GHS hazard classification for Oprozomib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Oprozomib?

Oprozomib is usually classified under HS code 293410 (Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Oprozomib?

CompoundList lists 4 suppliers of Oprozomib in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Oprozomib?

Suppliers quote Oprozomib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Oprozomib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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