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Pharmaceuticals and APIs

Osilodrostat

Also known as (+)-Osilodrostat, 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile, LCI 699

CAS 928134-65-0Formula C13H10FN3Molar mass 227.24 g/mol
4 suppliers listed Drug substance
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Osilodrostat chemical structure, C13H10FN3, CAS 928134-65-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
928134-65-0
Formula
C13H10FN3
Molar mass
227.24 g/mol
HS code
293399
Category
Pharmaceuticals and APIs

What is Osilodrostat?

Plain description, key identifiers and synonyms

Osilodrostat is an orally bioavailable inhibitor of both steroid 11beta-hydroxylase (cytochrome P450 (CYP) 11B1) and aldosterone synthase (CYP11B2, steroid 18-hydroxylase), with potential anti-adrenal activity and ability to treat Cushing disease (CD). Upon administration, osilodrostat binds to and inhibits the activity of CYP11B1, the enzyme that catalyzes the final step of cortisol synthesis from the precursor 11-deoxycortisol, and CYP11B2, the enzyme that catalyzes aldosterone synthesis from corticosterone and 11-deoxycorticosterone in the adrenal gland. The inhibition of CYP11B1 prevents the production of excess cortisol, thereby decreasing and normalizing the levels of cortisol. CD is most often caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary tumor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile
CAS number
928134-65-0 CAS number cross-checkedOther or deprecated CAS: 1304733-26-3
Molecular formula
C13H10FN3
UNII
5YL4IQ1078
MDL number
MFCD25976825
InChIKey
USUZGMWDZDXMDG-CYBMUJFWSA-N
InChI
InChI=1S/C13H10FN3/c14-12-5-9(6-15)1-3-11(12)13-4-2-10-7-16-8-17(10)13/h1,3,5,7-8,13H,2,4H2/t13-/m1/s1
Canonical SMILES
N#Cc1ccc(C2CCc3cncn32)c(F)c1
Isomeric SMILES
C1CC2=CN=CN2[C@H]1C3=C(C=C(C=C3)C#N)F

Synonyms

  • (+)-Osilodrostat
  • 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile
  • LCI 699
  • (R)-4-(6,7-Dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile
  • 3-Fluoro-4-[(5R)-5H,6H,7H-pyrrolo[1,2-c]imidazol-5-yl]benzonitrile
  • 4-((5R)-6,7-Dihydro-5H-pyrrolo(1,2-c)imidazol-5-yl)-3-fluoro-benzonitrile
  • Benzonitrile, 4-((5R)-6,7-dihydro-5H-pyrrolo(1,2-c)imidazol-5-yl)-3-fluoro-
  • 4-(R)-(6,7-Dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile
  • osilodrostatum
  • (R)-4-(6,7-Dihydro-5H-pyrrolo(1,2-c)imidazol-5-yl)-3-fluorobenzonitrile
  • 3-fluoro-4-((5R)-5H,6H,7H-pyrrolo(1,2-c)imidazol-5-yl)benzonitrile
  • 4-(R)-(6,7-Dihydro-5H-pyrrolo(1,2-c)imidazol-5-yl)-3-fluorobenzonitrile
  • 4-((5R)-6,7-dihydro-5H-pyrrolo(1,2-c)imidazol-5-yl)-3-fluorobenzonitrile
  • 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluoro-benzonitrile
  • Osilodrostat (LCI699)
  • 4-[(4R,5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile
  • Osilodrostat free base
  • Isturisa (Osilodrostat)
  • Osilodrostat (USAN/INN)
  • Osilodrostat, 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
227.24 g/molcalc.
Exact mass
227.0859 Dacalc.
LogP (octanol/water)
2.43calc.
Topological polar surface area
41.61 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
17calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.23calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(C2CCc3cncn32)cc1

c1ccc(C2CCc3cncn32)cc1

3 rings, 14 atoms.

11 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Osilodrostat suppliers

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All 4 suppliers
4 of 4 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

4 suppliers in 3 countries

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Osilodrostat price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antihypertensive agent
  • cardiovascular drug
  • pharmaceutical
  • protective agent
  • renoprotective agent

Pharmacology

Osilodrostat is a Cortisol Synthesis Inhibitor. The mechanism of action of osilodrostat is as a Cytochrome P450 11B1 Inhibitor, and Cytochrome P450 1A2 Inhibitor, and Cytochrome P450 2C19 Inhibitor, and Cytochrome P450 2D6 Inhibitor, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A5 Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Osilodrostat is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Osilodrostat is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Osilodrostat, based on the data on this page

What is Osilodrostat?

Osilodrostat is an orally bioavailable inhibitor of both steroid 11beta-hydroxylase (cytochrome P450 (CYP) 11B1) and aldosterone synthase (CYP11B2, steroid 18-hydroxylase), with potential anti-adrenal activity and ability to treat Cushing disease (CD).

What is the CAS number of Osilodrostat?

The CAS registry number of Osilodrostat is 928134-65-0. Other or deprecated CAS numbers: 1304733-26-3.

What is the molecular formula and weight of Osilodrostat?

The molecular formula of Osilodrostat is C13H10FN3 and its molar mass is 227.24 g/mol.

What is Osilodrostat used for?

Known uses and roles of Osilodrostat include antihypertensive agent, cardiovascular drug, pharmaceutical, protective agent and renoprotective agent.

Is Osilodrostat hazardous?

No GHS hazard classification for Osilodrostat is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Osilodrostat?

Osilodrostat is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Osilodrostat?

CompoundList lists 4 suppliers of Osilodrostat in China, India and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Osilodrostat in India?

1 supplier in India list Osilodrostat on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Osilodrostat?

Suppliers quote Osilodrostat on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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