Papaverine (CAS 58-74-2): properties, price, suppliers and safety

What is Papaverine?

Plain description, key identifiers and synonyms

Papaverine is a benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum. It has a role as a vasodilator agent and an antispasmodic drug. It is a benzylisoquinoline alkaloid, a member of isoquinolines and a dimethoxybenzene.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name: 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline
CAS number: 58-74-2 CAS number cross-checkedOther or deprecated CAS: 61-25-6
EC number: 200-397-2
Molecular formula: C₂₀H₂₁NO₄
UNII: DAA13NKG2Q
MDL number: MFCD00024138
InChIKey: XQYZDYMELSJDRZ-UHFFFAOYSA-N
InChI: InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
SMILES (canonical and isomeric): COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC

Synonyms

Robaxapap
1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline
6,7-Dimethoxy-1-veratrylisoquinoline
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline
Pavacap
Papaverinum
1-((3,4-Dimethoxyphenyl)methyl)-6,7-dimethoxyisoquinoline
Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-
Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-
Pavatym
Papaverin
Papanerine
Papanerin
Papaverina
Pavabid
Papaverine free base
Isoquinoline, 6,7-dimethoxy-1-veratryl-
S-M-R
Papaverine (BAN)
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline
4-[(6,7-Dimethoxyisoquinolyl)methyl]-1,2-dimethoxybenzene
Pavacot
Ceraspan
Mesotina (TN)
6,7-dimethoxy-1-veratryl-isoquinoline, hydrochloride

Show all 33 synonyms

Pavadyl
58-74-2 (free base)
2wey
RS 47
6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)isoquinoline
Noscapine Impurity 4
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline, hydrochloride
Isoquinoline, 6,7-dimethoxy-1-veratryl-(8Cl)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance	White prisms from alcohol-diethyl ether, needles from petroleum etherexp.
Melting point	147.5 °Cexp.
Boiling point	135 °Cexp.
Density	1.337 g/cm³ at 20 °Cexp.
Solubility	In water, 3.733 × 10⁻⁵ mg/L at 37.5 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight	339.39 g/molcalc.
Exact mass	339.1471 Dacalc.
LogP (octanol/water)	3.86calc.
Topological polar surface area	49.81 Å²calc.
Hydrogen bond donors	0calc.
Hydrogen bond acceptors	5calc.
Rotatable bonds	6calc.
Heavy atoms	25calc.
Rings	3calc.
Aromatic rings	3calc.
Fraction sp3 carbons	0.25calc.
Formal charge	0calc.
Stereocentres	0calc.
Lipinski rule of five	Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

c1ccc(Cc2nccc3ccccc23)cc1

3 rings, 17 atoms, the 1-Benzylisoquinoline ring system.

133 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word

Warning

Harmful or irritant

Hazard statements

H302Harmful if swallowed.

Precautionary statements (5)

P264Wash skin thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301 + P317If swallowed: Get medical help.
P330Rinse mouth.
P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Papaverine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 43 suppliers

Verified only30 of 30 offers

Indo German Alkaloids
India, Mumbai ManufacturerUnclaimed profile
PapaverineGrade, purity and minimum order on request
Price on request
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Faran Shimi Pharmaceutical Company
Iran, Tehran ManufacturerUnclaimed profile
PapaverineGrade, purity and minimum order on request
Price on request
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Vonage Pharma
Turkey ManufacturerUnclaimed profile
PapaverineGrade, purity and minimum order on request
Price on request
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Spark Lifesciences
India, VadodaraUnclaimed profile
PapaverineGrade, purity and minimum order on request
Price on request
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Quimica Alkano
BrazilUnclaimed profile
PapaverineGrade, purity and minimum order on request
Price on request
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10X Chem
United States, San DiegoUnclaimed profile
PapaverineGrade, purity and minimum order on request
Price on request
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A2B Chem LLC
United States, San DiegoUnclaimed profile
PapaverineGrade, purity and minimum order on request
Price on request
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Aa Blocks LLC
United States, San DiegoUnclaimed profile
PapaverineGrade, purity and minimum order on request
Price on request
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AbaChemScene, LLC
United States, Monmouth JunctionUnclaimed profile
PapaverineGrade, purity and minimum order on request
Price on request
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AgroIntelBioScan.com
Singapore, SingaporeUnclaimed profile
PapaverineGrade, purity and minimum order on request
Price on request
View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

43 suppliers in 16 countries

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Papaverine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

A vasodilator used for treatment of hypertension (also as the hydrochloride which is soluble in water).

Veterinary medication:.

Use classes: Pharmaceuticals.

Industries and functions

Cardiovascular drugs in pharmaceuticals

Pharmacological actions

Phosphodiesterase Inhibitors
Urological Agents
Vasodilator Agents

Roles

antidiarrhoeal drug
antineoplastic agent
antispasmodic drug
cardiovascular drug
gastrointestinal drug
muscle relaxant
neuromuscular agent
pharmaceutical
vasodilator agent

Pharmacology

Papaverine is an opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. As a direct-acting smooth muscle relaxant, papaverine is not closely related to the other opium alkaloids in structure or pharmacological actions, its mechanism of action may involve the non-selective inhibition of phosphodiesterases and direct inhibition of calcium channels. This agent also exhibits antiviral activity against respiratory syncytial virus, cytomegalovirus, and HIV. (NCI04)

How it is made

From opium or by synthesis.

Papaverine was synthesized via the Bischler-Napieralski reaction as follows: the Schotten-Baumann reaction between the phenethylamine and the acyl chloride gave the amide. Cyclization with phosphorous pentoxide afforded the 3,4-dihydroisoquinoline. Mild dehydrogenation of (3,4-dihydroisoquinoline) gave papaverine.

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

EU harmonised classification (CLP Annex VI)
Index no: 614-018-00-7

Health and food

Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Papaverine is traded under.

HS 2939.19Indicative HS code

Alkaloids of opium and their derivatives, salts thereof, other

World exports in 2024

$239M

+42.2% vs 2023, imports $256M

2019 to 2024

Top exporters

United States19.1%
Hungary17.1%
India * partner reported15.8%

Top importers

United States19.6%
India * partner reported17.4%
Canada9.8%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Papaverine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Parent and salt forms, stereoisomers, similar structures and isomers

Salt and hydrate forms

Records that share this compound as their parent

Papaverine hydrochloride chemical structure, C20H22ClNO4, CAS 61-25-6

Papaverine hydrochloride61-25-6C₂₀H₂₂ClNO₄87 suppliers

Papaverine sulfate chemical structure, C20H23NO8S, CAS 2053-26-1

Papaverine sulfate2053-26-1C₂₀H₂₃NO₈S

Papaverine hydrobromide chemical structure, C20H22BrNO4, CAS 6152-78-9

Papaverine hydrobromide6152-78-9C₂₀H₂₂BrNO₄

Papaverine nicotinate chemical structure, C26H26N2O6, CAS 1748-09-0

Papaverine nicotinate1748-09-0C₂₆H₂₆N₂O₆

Papaverine nitrite chemical structure, C20H22N2O6, CAS 132-40-1

Papaverine nitrite132-40-1C₂₀H₂₂N₂O₆

5-Oxo-L-proline, compound with 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline (1:1) chemical structure, C25H28N2O7, CAS 93940-80-8

5-Oxo-L-proline, compound with 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline (1:1)93940-80-8C₂₅H₂₈N₂O₇

Similar structures

Nearest neighbours by Morgan fingerprint Tanimoto similarity

Ethaverine hydrochloride chemical structure, C24H30ClNO4, CAS 985-13-7

Pseudocoralyne chemical structure, C22H23NO5, CAS 38714-92-0

61% similar

Pseudocoralyne38714-92-0C₂₂H₂₃NO₅

Same formula isomers

Different compounds that share this molecular formula

All isomers

(±)-Tetrahydroberberine chemical structure, C20H21NO4, CAS 522-97-4

(±)-Tetrahydroberberine522-97-4C₂₀H₂₁NO₄15 suppliers

(R)-Canadine chemical structure, C20H21NO4, CAS 2086-96-6

(R)-Canadine2086-96-6C₂₀H₂₁NO₄2 suppliers

(S)-Canadine chemical structure, C20H21NO4, CAS 5096-57-1

(S)-Canadine5096-57-1C₂₀H₂₁NO₄

Nantenine chemical structure, C20H21NO4, CAS 2565-01-7

Nantenine2565-01-7C₂₀H₂₁NO₄

(+)-Dicentrine chemical structure, C20H21NO4, CAS 517-66-8

(+)-Dicentrine517-66-8C₂₀H₂₁NO₄1 supplier

(-)-Dicentrine chemical structure, C20H21NO4, CAS 28832-07-7

(-)-Dicentrine28832-07-7C₂₀H₂₁NO₄

$Ethyl 6-{2,4-dioxo-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(13),5,7,9,11-pentaen-3-yl}hexanoate chemical structure, C20H21NO4, CAS 300815-53-6$

Ethyl 6-{2,4-dioxo-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(13),5,7,9,11-pentaen-3-yl}hexanoate300815-53-6C₂₀H₂₁NO₄

N-((9H-Fluoren-9-ylmethoxy)carbonyl)-L-valine chemical structure, C20H21NO4, CAS 126727-02-4

N-((9H-Fluoren-9-ylmethoxy)carbonyl)-L-valine126727-02-4C₂₀H₂₁NO₄5 suppliers

Crebanine chemical structure, C20H21NO4, CAS 25127-29-1

Crebanine25127-29-1C₂₀H₂₁NO₄2 suppliers

Phenicaberan chemical structure, C20H21NO4, CAS 95696-19-8

Phenicaberan95696-19-8C₂₀H₂₁NO₄

FMOC-L-valine chemical structure, C20H21NO4, CAS 68858-20-8

FMOC-L-valine68858-20-8C₂₀H₂₁NO₄26 suppliers

(2R)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanoic acid chemical structure, C20H21NO4, CAS 84624-17-9

(2R)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanoic acid84624-17-9C₂₀H₂₁NO₄10 suppliers

Frequently asked questions

Quick answers about Papaverine, based on the data on this page

What is Papaverine?

Papaverine is a benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum. It has a role as a vasodilator agent and an antispasmodic drug.

What is the CAS number of Papaverine?

The CAS registry number of Papaverine is 58-74-2. Other or deprecated CAS numbers: 61-25-6.

What is the molecular formula and weight of Papaverine?

The molecular formula of Papaverine is C20H21NO4 and its molar mass is 339.39 g/mol.

What is Papaverine used for?

A vasodilator used for treatment of hypertension (also as the hydrochloride which is soluble in water). Veterinary medication:. Use classes: Pharmaceuticals.

Is Papaverine hazardous?

Papaverine carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Papaverine?

Papaverine is usually classified under HS code 293919 (Alkaloids of opium and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Papaverine?

CompoundList lists 43 suppliers of Papaverine in United States, China, Hong Kong, Germany and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Papaverine in India?

2 suppliers in India list Papaverine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Papaverine?

Suppliers quote Papaverine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Papaverine

Papaverine

Key facts

What is Papaverine?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Hazard statements

Papaverine suppliers

Where suppliers are based

Send one request to many suppliers

Papaverine price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Pharmacology

How it is made

Regulatory status

Europe

Health and food

HS code and trade data

Global trade

Frequently asked questions

What is Papaverine?

What is the CAS number of Papaverine?

What is the molecular formula and weight of Papaverine?

What is Papaverine used for?

Is Papaverine hazardous?

What is the HS code of Papaverine?

Where can I buy Papaverine?

Where can I buy Papaverine in India?

What is the price of Papaverine?

Guides for buyers

Get quotes for Papaverine

Key facts

What is Papaverine?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Hazard statements

Papaverine suppliers

Where suppliers are based

Send one request to many suppliers

Papaverine price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Pharmacology

How it is made

Regulatory status

Europe

Health and food

HS code and trade data

Global trade

Related chemicals

Salt and hydrate forms

Similar structures

Same formula isomers

Frequently asked questions

What is Papaverine?

What is the CAS number of Papaverine?

What is the molecular formula and weight of Papaverine?

What is Papaverine used for?

Is Papaverine hazardous?

What is the HS code of Papaverine?

Where can I buy Papaverine?

Where can I buy Papaverine in India?

What is the price of Papaverine?

Guides for buyers

Get quotes for Papaverine