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Analgesics and anti-inflammatories

Parthenolide

Also known as (-)-Parthenolide, (1S,2S,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one, (1S,2S,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo(9.3.0.02,4)tetradec-7-en-13-one

CAS 20554-84-1Formula C15H20O3Molar mass 248.32 g/molEC 692-532-0
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 16 suppliers listed
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Parthenolide chemical structure, C15H20O3, CAS 20554-84-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
20554-84-1
Formula
C15H20O3
Molar mass
248.32 g/mol
EC number
692-532-0
HS code
293220
Category
Analgesics and anti-inflammatories

What is Parthenolide?

Plain description, key identifiers and synonyms

(1Ar,7aS,10aS,10bS)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one is a germacranolide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1S,2S,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one
CAS number
20554-84-1 CAS number cross-checkedOther or deprecated CAS: 503551-53-9
EC number
692-532-0
Molecular formula
C15H20O3
INCI name
PARTHENOLIDE
InChIKey
KTEXNACQROZXEV-SLXBATTESA-N
InChI
InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13-,15+/m0/s1
Canonical SMILES
C=C1C(=O)OC2C1CCC(C)=CCCC1(C)OC21
Isomeric SMILES
C/C/1=C\CC[C@@]2([C@@H](O2)[C@@H]3[C@@H](CC1)C(=C)C(=O)O3)C

Synonyms

  • (-)-Parthenolide
  • (1S,2S,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one
  • (1S,2S,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo(9.3.0.02,4)tetradec-7-en-13-one
  • (1aR,7aS,10aS,10bS)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
  • 4,5alpha-Epoxy-6beta-hydroxygermacra-1(10),11(13)-dien-12-oic Acid gamma-Lactone
  • ACon1_001961
  • (1aR,7aS,10aS,10bS,E)-1a,5-dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-9(1aH)-one
  • Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-, (1aR,4E,7aS,10aS,10bS)-
  • Sesquiterpene lactone found in feverfew (Tanacetum parthenium)
  • (1S,2S,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.0,2,4]tetradec-7-en-13-one
  • Germacra-1(10),11(13)-dien-12-oic acid, 4,5alpha-epoxy-6beta-hydroxy-, gamma-lactone

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
248.32 g/molcalc.
Exact mass
248.1412 Dacalc.
LogP (octanol/water)
2.76calc.
Topological polar surface area
38.83 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
0calc.
Heavy atoms
18calc.
Rings
3calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C=C1C(=O)OC2C1CCC=CCCC1OC12

C=C1C(=O)OC2C1CCC=CCCC1OC12

3 rings, 16 atoms.

35 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H317May cause an allergic skin reaction.
  • H341Suspected of causing genetic defects.
Precautionary statements (11)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Parthenolide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 16 suppliers
16 of 16 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

16 suppliers in 4 countries

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Parthenolide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name PARTHENOLIDE(skin conditioning)

Roles

  • aetiopathogenetic role
  • allergen
  • analgesic
  • anti-inflammatory agent
  • anti-inflammatory drug
  • antirheumatic drug
  • drug allergen
  • inhibitor
  • non-narcotic analgesic
  • non-steroidal anti-inflammatory drug
  • peripheral nervous system drug
  • pharmaceutical

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Pharmacology

Parthenolide is a Standardized Chemical Allergen. The physiologic effect of parthenolide is by means of Increased Histamine Release and Cell-mediated Immunity.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Parthenolide is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Parthenolide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Parthenolide, based on the data on this page

What is Parthenolide?

(1Ar,7aS,10aS,10bS)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one is a germacranolide.

What is the CAS number of Parthenolide?

The CAS registry number of Parthenolide is 20554-84-1. Other or deprecated CAS numbers: 503551-53-9.

What is the molecular formula and weight of Parthenolide?

The molecular formula of Parthenolide is C15H20O3 and its molar mass is 248.32 g/mol.

What is Parthenolide used for?

Known uses and roles of Parthenolide include analgesics and antipyretics in pharmaceuticals, anti-inflammatories in pharmaceuticals, skin conditioning agents in cosmetics and personal care, aetiopathogenetic role, allergen and 12 more.

Is Parthenolide hazardous?

Parthenolide carries the GHS signal word "Warning". Main hazards: may cause an allergic skin reaction, suspected of causing genetic defects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Parthenolide?

Parthenolide is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Parthenolide?

CompoundList lists 16 suppliers of Parthenolide in China, United States, Israel and Thailand. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Parthenolide?

Suppliers quote Parthenolide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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