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Refrigerants and blowing agents

Pentafluoroethane

Also known as 1,1,1,2,2-Pentafluoroethane, Ethane, pentafluoro-, 1,1,2,2,2-Pentafluoroethane

CAS 354-33-6Formula C2HF5Molar mass 120.02 g/molEC 206-557-8
GHS signal word: Warning. Pictograms: Gas under pressure 26 suppliers listed
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Pentafluoroethane chemical structure, C2HF5, CAS 354-33-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless gas
Melting point
-100.6 °C
Boiling point
-48.1 °C
Density
Liquid density = 1.23 g/cm³ at 20 °C
HS code
290344
Category
Refrigerants and blowing agents
UN number
UN 3220
Illustrative photo, a bundle of gas cylinders on a manifold in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Pentafluoroethane?

Plain description, key identifiers and synonyms

Pentafluoroethane appears as a nonflammable gas. Heavier than air. May asphyxiate by the displacement of air in confined spaces. Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1,1,1,2,2-pentafluoroethane
CAS number
354-33-6 CAS number cross-checked
EC number
206-557-8
Molecular formula
C2HF5
UNII
6TQ8593LRQ
MDL number
MFCD00042101
InChIKey
GTLACDSXYULKMZ-UHFFFAOYSA-N
InChI
InChI=1S/C2HF5/c3-1(4)2(5,6)7/h1H
SMILES (canonical and isomeric)
C(C(F)(F)F)(F)F

Synonyms

  • 1,1,1,2,2-Pentafluoroethane
  • Ethane, pentafluoro-
  • 1,1,2,2,2-Pentafluoroethane
  • Khladon 125
  • Fron 125
  • Freon 125
  • HCFC 125
  • Ethane, 1,1,1,2,2-pentafluoro-
  • FC 125
  • Hfc 125
  • Fc-125
  • 1H-perfluoroethane
  • Ethane,1,1,1,2,2-pentafluoro-
  • Ecolo Ace 125
  • Genetron HFC 125
  • Pentafluoroethane 99%
  • Norflurane EP Impurity Mm
  • HFA 125
  • HFO 125
  • Ethyl, 1,1,2,2,2-pentafluoro-
  • Pentafluoroethane or Refrigerant gas R 125
  • Controlled Substance<br>(Norflurane EP Impurity MM)
  • Pentafluoroethane or Refrigerant gas R 125 [UN3220] [Nonflammable gas]

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless gasexp.
Melting point
-100.6 °Cexp.
Boiling point
-48.1 °Cexp.
Density
Liquid density = 1.23 g/cm³ at 20 °Cexp.
Vapour pressure
9501 mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
120.02 g/molcalc.
Exact mass
119.9998 Dacalc.
LogP (octanol/water)
1.81calc.
Topological polar surface area
0 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
0calc.
Rotatable bonds
0calc.
Heavy atoms
7calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS04: Gas under pressure
Gas under pressure

Hazard statements

  • H280Contains gas under pressure, may explode if heated.
Precautionary statements (1)
  • P410 + P403Protect from sunlight. Store in a well-ventilated place.
UN number
UN 3220
Transport hazard class
2.2

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Pentafluoroethane suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 26 suppliers
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Where suppliers are based

26 suppliers in 7 countries

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Pentafluoroethane price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

According to the AFEAS database, more than 99% of HFC-125 produced worldwide by the reporting companies is used as a blend component for commercial refrigeration and air conditioning systems. The use as a fire-extinguishing agent in total flooding systems is another application of HFC-125. Minor applications include the use of HFC-125 in plastic foam blowing and as a solvent in special applications.

Refrigerant.

Non-polymer PFAS -> Electronic Industry -> Electrical equipment, appliance, and component manufacturing

Non-polymer PFAS -> Electronic Industry -> Heat transfer fluids (cooling of electrical equipment)

Non-polymer PFAS -> Air conditioning -> Air conditioning

Non-polymer PFAS -> Food Production Industry -> Manufacture of food products and beverages

Non-polymer PFAS -> Chemical Industry -> Production of other chemicals

Non-polymer PFAS -> Refrigerant systems -> Refrigerants

Non-pol

Read more

ymer PFAS -> Flame Retardants -> Flame retardants and extinguishing agents

Non-polymer PFAS -> Machinery and equipment -> (Electrical) machinery and equipment

Non-polymer PFAS -> Cleaning compositions -> Cleaning compositions in general

Non-polymer PFAS -> Building and Construction -> General use.

Refrigerant - Heat transfer fluid

Foaming agent for protein fire fighting foams

Construction

Cleaning/washing agents

Heat transfer agent

Air Conditioner/Refrigeration in Industrial gas manufacturing

Cooling agent

Functional fluids (closed systems) in electrical equipment, appliance, and component manufacturing

Refrigerant

Manufacture of food products and beverages

Machinery and equipment

Manufacture of chemicals and chemical products

Flame ratardant and fire extinguishing agent

Functional fluids (closed systems) in machinery manufacturing.

Functional uses

  • Fire extinguishing agent

How it is made

Higher temperatures and higher hydrogen fluoride-to-substrate ratios are necessary to achieve complete replacement of all chlorine atoms in the starting chloro compounds by fluorine. Both liquid-phase halogen exchange in the presence of catalysts, such as antimony(V) or tin(IV) chlorofluorides and vapor phase reactions using solid-phase catalysts based on chromium are employed. Preferred starting materials are chloroform for HFC 23, dichloromethane for HFC 32, and 1,1,1-trichloroethane for HFC 143a.

Read more

The conversion of tetrachloroethylene to HFC 125 and trichloroethylene to HFC 134a involves initial HF-addition across the double bond followed by a series of chlorine-fluorine exchange reactions.

Fluorination of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123) is employed to manufacture 2-chloro-1,1,1,2-tetrafluoroethane (HCFC-124), which in turn is fluorinated to 1,1,1,2,2-pentafluoroethane (HFC-125).

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce, Regulatory flags: Added by a premanufacture notice

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Pentafluoroethane is traded under.

HS 2903.44Exact HS code

Pentafluoroethane (HFC-125), 1,1,1-trifluoroethane (HFC-143a) and 1,1,2-trifluoroethane…

World exports in 2024
$97.3M
−56.4% vs 2023, imports $111M
2022 to 2024
Top exporters
  1. China56.5%
  2. India * partner reported18.6%
  3. Lithuania4.5%
Top importers
  1. United States27.5%
  2. Netherlands10.9%
  3. United Arab Emirates * partner reported7.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Pentafluoroethane is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Pentafluoroethane, based on the data on this page

What is Pentafluoroethane?

Pentafluoroethane appears as a nonflammable gas. Heavier than air. May asphyxiate by the displacement of air in confined spaces. Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket.

What is the CAS number of Pentafluoroethane?

The CAS registry number of Pentafluoroethane is 354-33-6.

What is the molecular formula and weight of Pentafluoroethane?

The molecular formula of Pentafluoroethane is C2HF5 and its molar mass is 120.02 g/mol.

What is Pentafluoroethane used for?

According to the AFEAS database, more than 99% of HFC-125 produced worldwide by the reporting companies is used as a blend component for commercial refrigeration and air conditioning systems. The use as a fire-extinguishing agent in total flooding systems is another application of HFC-125.

Is Pentafluoroethane hazardous?

Pentafluoroethane carries the GHS signal word "Warning". Main hazards: contains gas under pressure, may explode if heated. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Pentafluoroethane?

Pentafluoroethane is usually classified under HS code 290344 (Pentafluoroethane (HFC-125), 1,1,1-trifluoroethane (HFC-143a) and 1,1,2-trifluoroethane…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Pentafluoroethane?

CompoundList lists 26 suppliers of Pentafluoroethane in United States, China, India, South Korea and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Pentafluoroethane in India?

4 suppliers in India list Pentafluoroethane on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Pentafluoroethane?

Suppliers quote Pentafluoroethane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Pentafluoroethane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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