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Antibiotics and anti-infectives

Pentamidine

Also known as Pentamidina, 4,4'-(Pentamethylenedioxy)dibenzamidine, Pentamidin

CAS 100-33-4Formula C19H24N4O2Molar mass 340.43 g/molEC 202-841-0
GHS signal word: Warning. Pictograms: Harmful or irritant 74 suppliers listed Drug substance
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Pentamidine chemical structure, C19H24N4O2, CAS 100-33-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystallizes as colorless plates from water
Melting point
186 °C
Solubility
Mol wt: 592.69. Hygroscopic, very bitter crystals, mp approx 180 °C. Slight butyric odor…
HS code
292529
Category
Antibiotics and anti-infectives
Illustrative photo, colourless crystals beside a jumbo bulk bag in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Pentamidine?

Plain description, key identifiers and synonyms

Pentamidine is a diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease. It has a role as a calmodulin antagonist, a S100 calcium-binding protein B inhibitor, a xenobiotic, an antifungal agent, a trypanocidal drug, a NMDA receptor antagonist, a chemokine receptor 5 antagonist, an anti-inflammatory agent and an EC 2.3.1.48 (histone acetyltransferase) inhibitor. It is a carboxamidine, an aromatic ether and a diether. It is a conjugate base of a pentamidinium(2+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
CAS number
100-33-4 CAS number cross-checked
EC number
202-841-0
Molecular formula
C19H24N4O2
UNII
673LC5J4LQ
MDL number
MFCD00599574
InChIKey
XDRYMKDFEDOLFX-UHFFFAOYSA-N
InChI
InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
SMILES (canonical and isomeric)
C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N

Synonyms

  • Pentamidina
  • 4,4'-(Pentamethylenedioxy)dibenzamidine
  • Pentamidin
  • Pentamidinum
  • 4,4'-Diamidinodiphenoxypentane
  • p,p'-(Pentamethylenedioxy)dibenzamidine
  • Pentam 300 (as isethionate)
  • Nebupent (as isethionate)
  • Pentacarinat (as isethionate)
  • 1,5-bis(4-amidinophenoxy)pentane
  • Benzenecarboximidamide, 4,4'-[1,5-pentanediylbis(oxy)]bis-
  • MB 800 FREE BASE
  • MB-800 FREE BASE
  • 4,4'-(1,5-Pentanediylbis(oxy))bis-benzenecarboximidamide
  • RP 2512 FREE BASE
  • RP-2512 FREE BASE
  • 4-{[5-(4-carbamimidoylphenoxy)pentyl]oxy}benzene-1-carboximidamide
  • mb-800 (As isethionate)
  • 4,4'-[1,5-Pentanediylbis(oxy)]bis-benzenecarboximidamide
  • Benzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis-
  • 4-((5-(4-carbamimidoylphenoxy)pentyl)oxy)benzene-1-carboximidamide
  • Aerosolized Pentamadine
  • Pentamidini mesilas
  • 4,4'-(Pentane-1,5-diylbis(oxy))dibenzimidamide
  • Pentamide
Show all 34 synonyms
  • 4-[5-(4-Carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
  • Pentamidine (INN)
  • PNT
  • GNF-Pf-3680
  • 4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide
  • 4-[5-(4-carbamimidoylphenoxy)pentoxy]benzamidine
  • Lomidine (TN)
  • 4, 4'-Diamidinodiphenoxypentane
  • 1,3-Bis(4-amidinophenoxy)pentane

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystallizes as colorless plates from waterexp.
Melting point
186 °Cexp.
Solubility
Mol wt: 592.69. Hygroscopic, very bitter crystals, mp approx 180 °C. Slight butyric odor. Sol in water (approx 1 in 10 at 25 °C, approx 1 in 4 at 100 °C), sol in glycerol, more readily on warming, slightly sol in alcohol.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
340.43 g/molcalc.
Exact mass
340.1899 Dacalc.
LogP (octanol/water)
2.88calc.
Topological polar surface area
118.2 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
10calc.
Heavy atoms
25calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.26calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(OCCCCCOc2ccccc2)cc1

c1ccc(OCCCCCOc2ccccc2)cc1

2 rings, 19 atoms, the Benzene, 1,1'-(1,5-pentanediylbis(oxy))bis- ring system.

78 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Pentamidine suppliers

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All 74 suppliers
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Where suppliers are based

74 suppliers in 10 countries

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Pentamidine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Antiprotozoal (Trypanosoma, Leishmania), antipneumocystic.

Therapeutic category (veterinary): Antiprotozoal (Babesia, Leishmania).

Industries and functions

Pharmacological actions

  • Antifungal Agents
  • Antiprotozoal Agents
  • Trypanocidal Agents

Roles

  • NMDA receptor antagonist
  • S100 calcium-binding protein B inhibitor
  • antagonist
  • anti-inflammatory agent
  • antifungal agent
  • antiinfective agent
  • antileishmanial agent
  • antimicrobial agent
  • antimicrobial drug
  • antineoplastic agent
  • antiparasitic agent
  • antiprotozoal drug
  • calmodulin antagonist
  • chemokine receptor 5 antagonist
  • enzyme inhibitor
  • excitatory amino acid antagonist
  • hypoglycemic agent
  • pharmaceutical
  • protective agent
  • renoprotective agent
  • trypanocidal drug
  • xenobiotic

Pharmacology

Pentamidine is an Antiprotozoal.

How it is made

Saturating an anhydrous alcoholic solution of 4,4'-dicyanodiphenoxypentane with dry hydrogen chloride and allowing it to stand gives pentamidine.

Preparation: A.J. Ewins, GB 507565 (1939)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Pentamidine is traded under.

HS 2925.29Indicative HS code

Imines and their derivatives, salts thereof, other

World exports in 2024
$1.8B
+12.4% vs 2023, imports $1.84B
2019 to 2024
Top exporters
  1. China35.9%
  2. France * partner reported15.5%
  3. Germany9.1%
Top importers
  1. United States13.3%
  2. China13.0%
  3. Brazil9.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Pentamidine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Pentamidine, based on the data on this page

What is Pentamidine?

Pentamidine is a diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.

What is the CAS number of Pentamidine?

The CAS registry number of Pentamidine is 100-33-4.

What is the molecular formula and weight of Pentamidine?

The molecular formula of Pentamidine is C19H24N4O2 and its molar mass is 340.43 g/mol.

What is Pentamidine used for?

Therapeutic category: Antiprotozoal (Trypanosoma, Leishmania), antipneumocystic. Therapeutic category (veterinary): Antiprotozoal (Babesia, Leishmania).

Is Pentamidine hazardous?

Pentamidine carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Pentamidine?

Pentamidine is usually classified under HS code 292529 (Imines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Pentamidine?

CompoundList lists 74 suppliers of Pentamidine in United States, China, United Kingdom, Germany and 6 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Pentamidine?

Suppliers quote Pentamidine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Pentamidine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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