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Cosmetic preservatives

Hexamidine

Also known as Hexamidina, Hexamidinum, 4,4'-(1,6-Hexanediylbis(oxy))bis-benzenecarboximidamide

CAS 3811-75-4Formula C20H26N4O2Molar mass 354.45 g/mol
1 supplier listed
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Hexamidine chemical structure, C20H26N4O2, CAS 3811-75-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
3811-75-4
Formula
C20H26N4O2
Molar mass
354.45 g/mol
HS code
292529
Category
Cosmetic preservatives

What is Hexamidine?

Plain description, key identifiers and synonyms

Hexamidine is a polyether that is the bis(4-guanidinophenyl) ether of hexane-1,6-diol. It has a role as an antimicrobial agent and an antiseptic drug. It is a member of guanidines, an aromatic ether and a polyether. It is functionally related to a hexane-1,6-diol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide
CAS number
3811-75-4 CAS number cross-checked
Molecular formula
C20H26N4O2
UNII
3483C2H13H
INCI name
HEXAMIDINE
InChIKey
OQLKNTOKMBVBKV-UHFFFAOYSA-N
InChI
InChI=1S/C20H26N4O2/c21-19(22)15-5-9-17(10-6-15)25-13-3-1-2-4-14-26-18-11-7-16(8-12-18)20(23)24/h5-12H,1-4,13-14H2,(H3,21,22)(H3,23,24)
SMILES (canonical and isomeric)
C1=CC(=CC=C1C(=N)N)OCCCCCCOC2=CC=C(C=C2)C(=N)N

Synonyms

  • Hexamidina
  • Hexamidinum
  • 4,4'-(1,6-Hexanediylbis(oxy))bis-benzenecarboximidamide
  • Benzenecarboximidamide, 4,4'-(1,6-hexanediylbis(oxy))bis-
  • 1,6-di(para-amidinophenoxy)hexane
  • 4-{[6-(4-carbamimidoylphenoxy)hexyl]oxy}benzene-1-carboximidamide
  • 4-((6-(4-carbamimidoylphenoxy)hexyl)oxy)benzene-1-carboximidamide
  • 1,6-di-(4-amidinophenoxy)hexane
  • 4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide
  • 4,4'[1,6-Hexanediylbis(oxy)]bisbenzenecarboximidamide
  • 4,4'-[hexane-1,6-diylbis(oxy)]di(benzene-1-carboximidamide)
  • Hexamidine (INN/BAN)
  • 4-[6-(4-carbamimidoylphenoxy)hexoxy]benzamidine
  • 1,6-Di(4-amidinophenoxy)hexane
  • 1,6-Di (4-amidinophenoxy)-n-hexane
  • 4-[6-(4-Carbamimidoyl-phenoxy)-hexyloxy]-benzamidine
  • 4,4'-[hexane-1,6-diylbis(oxy)]dibenzenecarboximidamide
  • 4,4''''[1,6-Hexanediylbis(oxy)]bisbenzenecarboximidamide
  • 4-{6-[4-amino(imino)methylphenoxy]hexyloxy}phenyl-iminomethanamine
  • 4-{6-[4-ammino(imino)methylphenoxy]hexyloxy}phenyl-iminomethanammine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
354.45 g/molcalc.
Exact mass
354.2056 Dacalc.
LogP (octanol/water)
3.27calc.
Topological polar surface area
118.2 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
11calc.
Heavy atoms
26calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.3calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(OCCCCCCOc2ccccc2)cc1

c1ccc(OCCCCCCOc2ccccc2)cc1

2 rings, 20 atoms, the 1,6-Diphenoxyhexane ring system.

54 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Hexamidine suppliers

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  • CD Formulation
    United States, ShirleyUnclaimed profile
    HexamidineGrade, purity and minimum order on request
    Price on request
    View

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Where suppliers are based

1 supplier in 1 country

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Hexamidine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Cosmetics.

Cosmetic ingredient, INCI name HEXAMIDINE(preservative)

Pharmacological actions

  • Anti-Infective Agents

Roles

  • antiinfective agent
  • antimicrobial agent
  • antiseptic drug
  • nasal decongestant
  • ophthalmology drug
  • pharmaceutical

Functional uses

  • Preservative

Cosmetic functions

  • Preservative

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • EU Cosmetics Regulation Annex V, allowed preservative
    Name: HEXAMIDINE / HEXAMIDINE DIISETHIONATE / HEXAMIDINE DIPARABEN / HEXAMIDINE PARABEN, Ref no: 47, Annex ref: V/47

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Hexamidine is traded under.

HS 2925.29Indicative HS code

Imines and their derivatives, salts thereof, other

World exports in 2024
$1.8B
+12.4% vs 2023, imports $1.84B
2019 to 2024
Top exporters
  1. China35.9%
  2. France * partner reported15.5%
  3. Germany9.1%
Top importers
  1. United States13.3%
  2. China13.0%
  3. Brazil9.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Hexamidine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Hexamidine, based on the data on this page

What is Hexamidine?

Hexamidine is a polyether that is the bis(4-guanidinophenyl) ether of hexane-1,6-diol. It has a role as an antimicrobial agent and an antiseptic drug. It is a member of guanidines, an aromatic ether and a polyether. It is functionally related to a hexane-1,6-diol.

What is the CAS number of Hexamidine?

The CAS registry number of Hexamidine is 3811-75-4.

What is the molecular formula and weight of Hexamidine?

The molecular formula of Hexamidine is C20H26N4O2 and its molar mass is 354.45 g/mol.

What is Hexamidine used for?

Use classes: Cosmetics.

Is Hexamidine hazardous?

No GHS hazard classification for Hexamidine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Hexamidine?

Hexamidine is usually classified under HS code 292529 (Imines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Hexamidine?

CompoundList lists 1 supplier of Hexamidine in United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Hexamidine?

Suppliers quote Hexamidine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Hexamidine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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