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Refrigerants and blowing agents

Perfluorobutane

Also known as Perflubutane, Decafluorobutane, 1,1,1,2,2,3,3,4,4,4-Decafluorobutane

CAS 355-25-9Formula C4F10Molar mass 238.02 g/molEC 206-580-3
GHS signal word: Warning. Pictograms: Gas under pressure 12 suppliers listed
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Perfluorobutane chemical structure, C4F10, CAS 355-25-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless gas
Melting point
-129 °C
Boiling point
-2.1 °C
Density
1.6484 g/cm³ at 25 °C
Solubility
Soluble in benzene, chloroform
HS code
290349
Category
Refrigerants and blowing agents
Illustrative photo, a small gas cylinder with a regulator in a lab on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Perfluorobutane?

Plain description, key identifiers and synonyms

Perflubutane is a fluorocarbon that is butane in which all of the hydrogens have been replaced by fluorines. Microbubbles of preflubutane are used in the ultrasound contrast agent BR14. It has a role as an ultrasound contrast agent. It is a gas molecular entity, a fluoroalkane and a fluorocarbon.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1,1,1,2,2,3,3,4,4,4-decafluorobutane
CAS number
355-25-9 CAS number cross-checked
EC number
206-580-3
Molecular formula
C4F10
UNII
SE4TWR0K2C
MDL number
MFCD00042080
InChIKey
KAVGMUDTWQVPDF-UHFFFAOYSA-N
InChI
InChI=1S/C4F10/c5-1(6,3(9,10)11)2(7,8)4(12,13)14
SMILES (canonical and isomeric)
C(C(C(F)(F)F)(F)F)(C(F)(F)F)(F)F

Synonyms

  • Perflubutane
  • Decafluorobutane
  • 1,1,1,2,2,3,3,4,4,4-Decafluorobutane
  • perflubutano
  • perflubutanum
  • CEA 410
  • AI 700
  • FC 3110
  • PF 5040
  • NC 100100
  • PFC 31-10
  • AI700 compound
  • Sonazoid
  • Butane, decafluoro-
  • Perfluoro-n-butane
  • decafluoro-butane
  • Sonazoid (TN)
  • Perflubutane (JAN/USAN/INN)
  • Perfluorobutane (FC-31-10)
  • 1,1,1,2,2,3,3,4,4,4-Decafluorobutane #
  • SE4TWR0K2C355-25-9PerfluorobutanePerflubutane
  • Butane, 1,1,1,2,2,3,3,4,4,4-decafluoro-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless gasexp.
Melting point
-129 °Cexp.
Boiling point
-2.1 °Cexp.
Density
1.6484 g/cm³ at 25 °Cexp.
Solubility
Soluble in benzene, chloroformexp.
Vapour pressure
2.01 × 10⁺³ mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
238.02 g/molcalc.
Exact mass
237.984 Dacalc.
LogP (octanol/water)
3.38calc.
Topological polar surface area
0 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
0calc.
Rotatable bonds
1calc.
Heavy atoms
14calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS04: Gas under pressure
Gas under pressure

Hazard statements

  • H280Contains gas under pressure, may explode if heated.
Precautionary statements (1)
  • P410 + P403Protect from sunlight. Store in a well-ventilated place.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Perfluorobutane suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 12 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

12 suppliers in 5 countries

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Perfluorobutane price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Currently available microbubbles used for ultrasound imaging and therapeutics are limited to intravascular space due to their size distribution in the micron range. Phase-change contrast agents (PCCAs) have been proposed as a means to overcome this limitation, since droplets formed in the hundred nanometer size range might be able to extravasate through leaky microvasculature, after which they could be activated to form larger highly echogenic microbubbles. Existing PCCAs in the sub-micron size range require substantial acoustic energy to be vaporized, increasing the likelihood of unwanted bioeffects. Thus, there exists a need for PCCAs with reduced acoustic activation energies for use in imaging studies.

Read more

In this article, it is shown that decafluorobutane, which is normally a gas at room temperature, can be incorporated into metastable liquid sub-micron droplets with appropriate encapsulation methods. The resulting droplets are activatable with substantially less energy than other favored PCCA compounds. Decafluorobutane nanodroplets may present a new means to safely extend ultrasound imaging beyond the vascular space.

Sonazoid is an ultrasound contrast agent (UCA) consisting of stabilized (perfluorobutane) gas microbubbles in an aqueous suspension. Sonazoid has overcome the stability problems of first generation UCA and can produce myocardial perfusion images. Myocardial imaging using ultrasound contrast agents provides diagnosis of chronic heart disease and assessment of the coronary arteries and of the coronary blood flow reserve.

Medical research chemical.

Foaming agent for protein fire fighting foams

Used in contrast imaging applications

Plasma etching

Refrigerant.

Non-polymer PFAS -> Refrigerant systems -> Refrigerants

Roles

  • antihypertensive agent
  • antineoplastic agent
  • cardiovascular drug
  • diagnostic agent
  • diagnostic imaging agent
  • pharmaceutical
  • ultrasound contrast agent

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Perfluorobutane is traded under.

HS 2903.49Indicative HS code

Saturated fluorinated derivatives of acyclic hydrocarbons, other

World exports in 2024
$124M
−2.2% vs 2023, imports $134M
2022 to 2024
Top exporters
  1. Japan29.8%
  2. United States28.1%
  3. China18.7%
Top importers
  1. South Korea41.2%
  2. United States9.5%
  3. Singapore7.0%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Perfluorobutane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Perfluorobutane, based on the data on this page

What is Perfluorobutane?

Perflubutane is a fluorocarbon that is butane in which all of the hydrogens have been replaced by fluorines. Microbubbles of preflubutane are used in the ultrasound contrast agent BR14. It has a role as an ultrasound contrast agent. It is a gas molecular entity, a fluoroalkane and a fluorocarbon.

What is the CAS number of Perfluorobutane?

The CAS registry number of Perfluorobutane is 355-25-9.

What is the molecular formula and weight of Perfluorobutane?

The molecular formula of Perfluorobutane is C4F10 and its molar mass is 238.02 g/mol.

What is Perfluorobutane used for?

Currently available microbubbles used for ultrasound imaging and therapeutics are limited to intravascular space due to their size distribution in the micron range.

Is Perfluorobutane hazardous?

Perfluorobutane carries the GHS signal word "Warning". Main hazards: contains gas under pressure, may explode if heated. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Perfluorobutane?

Perfluorobutane is usually classified under HS code 290349 (Saturated fluorinated derivatives of acyclic hydrocarbons, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Perfluorobutane?

CompoundList lists 12 suppliers of Perfluorobutane in China, United States, United Kingdom, France and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Perfluorobutane?

Suppliers quote Perfluorobutane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Perfluorobutane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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