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Analgesics and anti-inflammatories

Phenacetin

Also known as N-(4-Ethoxyphenyl)acetamide, Acetophenetidin, Acetophenetidine

CAS 62-44-2Formula C10H13NO2Molar mass 179.22 g/molEC 200-533-0
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 96 suppliers listed
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Phenacetin chemical structure, C10H13NO2, CAS 62-44-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Monoclinic prisms
Melting point
134 to 135
Boiling point
242 to 245
Solubility
1 g dissolves in 1310 mL cold water, 82 mL boiling water, 15 mL cold alcohol, 2.8 mL boi…
HS code
292429
Category
Analgesics and anti-inflammatories
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Phenacetin?

Plain description, key identifiers and synonyms

Phenacetin is a member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a 4-ethoxyphenyl group. It has a role as a non-narcotic analgesic, a peripheral nervous system drug and a cyclooxygenase 3 inhibitor. It is a member of acetamides and an aromatic ether. It is functionally related to a N-phenylacetamide, a paracetamol and a 4-ethoxyaniline.

Phenacetin is a pharmaceutical drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-(4-ethoxyphenyl)acetamide
CAS number
62-44-2 CAS number cross-checkedOther or deprecated CAS: 40674-52-0
EC numbers
200-533-0, 695-035-7
Molecular formula
C10H13NO2
UNII
ER0CTH01H9
MDL number
MFCD00009094
INCI name
PHENACETIN
InChIKey
CPJSUEIXXCENMM-UHFFFAOYSA-N
InChI
InChI=1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)
SMILES (canonical and isomeric)
CCOC1=CC=C(C=C1)NC(=O)C

Synonyms

  • N-(4-Ethoxyphenyl)acetamide
  • Acetophenetidin
  • Acetophenetidine
  • Acetophenetin
  • Acetphenetidin
  • Phenacetine
  • Phenazetin
  • p-Acetophenetidide
  • Phenacetinum
  • Fenidina
  • Kalmin
  • Achrocidin
  • Codempiral
  • Contradol
  • Contradouleur
  • Fenacetina
  • Phenedina
  • p-Acetophenetidine
  • Pertonal
  • Phenidin
  • Phenin
  • p-Acetophenetide
  • 4-Ethoxyacetanilide
  • Phenacet
  • Phenacitin
Show all 39 synonyms
  • Pyraphen
  • Fenina
  • Acetamide, N-(4-ethoxyphenyl)-
  • p-Ethoxyacetanilide
  • p-Acetphenetidin
  • Acetylphenetidin
  • para-Phenacetin
  • N-Acetyl-p-phenetidine
  • Aceto-4-phenetidine
  • Acet-p-phenalide
  • Para-acetphenetidin
  • 1-Acetamido-4-ethoxybenzene
  • Aceto-para-phenalide
  • para-Acetophenetidide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Monoclinic prismsexp.
Odour
ODORLESSexp.
Taste
Slightly bitterexp.
Melting point
134 to 135exp.
Boiling point
242 to 245exp.
Solubility
1 g dissolves in 1310 mL cold water, 82 mL boiling water, 15 mL cold alcohol, 2.8 mL boiling alcohol, 14 mL chloroform, 90 mL ether, sol in glycerol.exp.
Vapour pressure
6.29 × 10⁻⁷ mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
179.22 g/molcalc.
Exact mass
179.0946 Dacalc.
LogP (octanol/water)
2.04calc.
Topological polar surface area
38.33 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
13calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.3calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H350May cause cancer.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Phenacetin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 96 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

96 suppliers in 16 countries

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Phenacetin price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Analgesic, antipyretic (Former, US).

Therapeutic category (veterinary): Analgesic, antipyretic (Former, US).

As stabilizer for hydrogen peroxide in hair bleaching prepn. (Former, US).

Veterinary medication:.

Use classes: Cosmetics, Pharmaceuticals.

Cosmetic ingredient, INCI name PHENACETIN(light stabilizer)

Pharmacological actions

  • Analgesics, Non-Narcotic

Roles

  • analgesic
  • cyclooxygenase 3 inhibitor
  • enzyme inhibitor
  • non-narcotic analgesic
  • peripheral nervous system drug
  • pharmaceutical

Functional uses

  • Stabilizing agent

Cosmetic functions

  • Light stabilizer

Pharmacology

Phenacetin is a synthetic, white crystalline solid that is slightly soluble in water and benzene, soluble in acetone and very soluble in pyrimidine. It is used in research as the preferred marker for detecting CYP1A2-based inhibition potential in vitro. Human ingestion of phenacetin can result in a bluish discoloration of the skin due to a lack of oxygen in the blood (cyanosis), dizziness and respiratory depression. It is reasonably anticipated to be a human carcinogen. (NCI05)

How it is made

Condensation of p-nitrophenol in a sodium hydroxide solution with ethyl bromide followed by reduction with sodium sulfide and acetylation with acetic anhydride.

Obtained by reacting p-nitrophenol with sodium hydroxide & ethyl sulfate, reducing nitrite to amine with iron & acid, & then acetylating by boiling with glacial acetic acid.

By interaction of para-phenetidin & glacial acetic acid, or of ethyl bromide & para-acetaminophenol. Method of purification: crystallization.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce, Regulatory flags: Significant new use rule

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Phenacetin is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Phenacetin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Phenacetin, based on the data on this page

What is Phenacetin?

Phenacetin is a member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a 4-ethoxyphenyl group. It has a role as a non-narcotic analgesic, a peripheral nervous system drug and a cyclooxygenase 3 inhibitor.

What is the CAS number of Phenacetin?

The CAS registry number of Phenacetin is 62-44-2. Other or deprecated CAS numbers: 40674-52-0.

What is the molecular formula and weight of Phenacetin?

The molecular formula of Phenacetin is C10H13NO2 and its molar mass is 179.22 g/mol.

What is Phenacetin used for?

Therapeutic category: Analgesic, antipyretic (Former, US). Therapeutic category (veterinary): Analgesic, antipyretic (Former, US). As stabilizer for hydrogen peroxide in hair bleaching prepn. (Former, US). Veterinary medication:. Use classes: Cosmetics, Pharmaceuticals.

Is Phenacetin hazardous?

Phenacetin carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may cause cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Phenacetin?

Phenacetin is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Phenacetin?

CompoundList lists 96 suppliers of Phenacetin in China, United States, Germany, United Kingdom and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Phenacetin?

Suppliers quote Phenacetin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Phenacetin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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