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Alkaloids

Phenothiazine

Also known as 10H-Phenothiazine, Thiodiphenylamine, Dibenzothiazine

CAS 92-84-2Formula C12H9NSMolar mass 199.28 g/molEC 202-196-5
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard, Hazardous to the environment 116 suppliers listed
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Phenothiazine chemical structure, C12H9NS, CAS 92-84-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Yellow, rhombic leaflets or diamond-shaped plates from toluene or butanol
Melting point
185.1 °C
Boiling point
371 °C
Density
1.34 g/cm³
Flash point
202 °C
HS code
293979
Category
Alkaloids
Illustrative photo, yellow pigment powder in a glass jar on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Phenothiazine?

Plain description, key identifiers and synonyms

10H-phenothiazine is the 10H-tautomer of phenothiazine. It has a role as a ferroptosis inhibitor, a radical scavenger and a plant metabolite. It is a tautomer of a 4aH-phenothiazine, a 1H-phenothiazine and a 3H-phenothiazine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
10H-phenothiazine
CAS number
92-84-2 CAS number cross-checkedOther or deprecated CAS: 75788-67-9
EC number
202-196-5
Molecular formula
C12H9NS
UNII
GS9EX7QNU6
MDL number
MFCD00005015
InChIKey
WJFKNYWRSNBZNX-UHFFFAOYSA-N
InChI
InChI=1S/C12H9NS/c1-3-7-11-9(5-1)13-10-6-2-4-8-12(10)14-11/h1-8,13H
SMILES (canonical and isomeric)
C1=CC=C2C(=C1)NC3=CC=CC=C3S2

Synonyms

  • 10H-Phenothiazine
  • Thiodiphenylamine
  • Dibenzothiazine
  • Contaverm
  • Dibenzo-1,4-thiazine
  • Fenoverm
  • Nemazine
  • Phenosan
  • Feeno
  • Phenthiazine
  • Antiverm
  • Fentiazin
  • Helmetina
  • Lethelmin
  • Padophene
  • Phenegic
  • Phenoverm
  • Phenovis
  • Phenoxur
  • Souframine
  • Orimon
  • Reconox
  • AFI-Tiazin
  • Agrazine
  • Fenotiazina
Show all 39 synonyms
  • Nemazene
  • Nexarbol
  • Penthazine
  • Phenzeen
  • Biverm
  • Thiodiphenylamin
  • Wurm-Thional
  • Dibenzoparathiazine
  • Early bird wormer
  • Fenothiazine
  • Tiodifenilamina
  • Thiodifenylamine
  • Danikoropa
  • ENT 38

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Yellow, rhombic leaflets or diamond-shaped plates from toluene or butanolexp.
Odour
SLIGHT ODORexp.
Taste
TASTELESSexp.
Melting point
185.1 °Cexp.
Boiling point
371 °Cexp.
Density
1.34 g/cm³exp.
Flash point
202 °Cexp.
Autoignition temperature
471 °Cexp.
Solubility
Water solubilty = 1.59 mg/l at 25 °Cexp.
Vapour pressure
0 mmHg (approx)exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
199.28 g/molcalc.
Exact mass
199.0456 Dacalc.
LogP (octanol/water)
3.89calc.
Topological polar surface area
12.03 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
0calc.
Heavy atoms
14calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)Nc1ccccc1S2

c1ccc2c(c1)Nc1ccccc1S2

3 rings, 14 atoms. This chemical is the scaffold itself.

1,001 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H317May cause an allergic skin reaction.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
  • H412Harmful to aquatic life with long lasting effects.
Precautionary statements (16)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Phenothiazine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 116 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

116 suppliers in 16 countries

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Phenothiazine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Manufacture of dyes, parent cmpd for chlorpromazine & related antipsychotic drugs, polymerization inhibitor, antioxidant.

Used in control of insects that breed in manure.

Synthesis of promethazine hydrochloride.

Polymerization inhibitor for chloroprene.

Industrial uses: Intermediate, Oxidizing agent, Defoamer, Stabilizing agent, Monomers, Processing aids not otherwise specified, Dispersing agent, Other.

Consumer uses: Hydraulic fluids, Intermediate, Other, Monomers.

Use classes: Animal Drugs.

Pharmacological actions

  • Antiprotozoal Agents

Roles

  • antioxidant
  • eukaryotic metabolite
  • ferroptosis inhibitor
  • metabolite
  • plant metabolite
  • radical scavenger

Pharmacology

Phenothiazine is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis. In addition, these agents have peripherally or centrally antagonistic activity against alpha adrenergic, serotonergic, histaminic, and muscarinic receptors. (NCI)

How it is made

By fusing diphenylamine with sulfur, improved yields with iodine as catalyst.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Phenothiazine (INN) and its compounds, Ref no: 320, Annex ref: II/320

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Phenothiazine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Phenothiazine is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Phenothiazine, based on the data on this page

What is Phenothiazine?

10H-phenothiazine is the 10H-tautomer of phenothiazine. It has a role as a ferroptosis inhibitor, a radical scavenger and a plant metabolite. It is a tautomer of a 4aH-phenothiazine, a 1H-phenothiazine and a 3H-phenothiazine.

What is the CAS number of Phenothiazine?

The CAS registry number of Phenothiazine is 92-84-2. Other or deprecated CAS numbers: 75788-67-9.

What is the molecular formula and weight of Phenothiazine?

The molecular formula of Phenothiazine is C12H9NS and its molar mass is 199.28 g/mol.

What is Phenothiazine used for?

Manufacture of dyes, parent cmpd for chlorpromazine & related antipsychotic drugs, polymerization inhibitor, antioxidant. Used in control of insects that breed in manure. Synthesis of promethazine hydrochloride. Polymerization inhibitor for chloroprene.

Is Phenothiazine hazardous?

Phenothiazine carries the GHS signal word "Warning". Main hazards: harmful if swallowed, may cause an allergic skin reaction, may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Phenothiazine?

Phenothiazine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Phenothiazine?

CompoundList lists 116 suppliers of Phenothiazine in China, United States, Germany, United Kingdom and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Phenothiazine in India?

4 suppliers in India list Phenothiazine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Phenothiazine?

Suppliers quote Phenothiazine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Phenothiazine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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