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Sweeteners

Phyllodulcin

Also known as d-Phyllodulcin, (3R)-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-3,4-dihydroisochromen-1-one, (3R)-8-hydroxy-3-(3-hydroxy-4-methoxy-phenyl)isochroman-1-one

CAS 21499-23-0Formula C16H14O5Molar mass 286.28 g/mol
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Phyllodulcin chemical structure, C16H14O5, CAS 21499-23-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
21499-23-0
Formula
C16H14O5
Molar mass
286.28 g/mol
HS code
293220
Category
Sweeteners

What is Phyllodulcin?

Plain description, key identifiers and synonyms

Phyllodulcin is a hydroxybenzoic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3R)-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-3,4-dihydroisochromen-1-one
CAS number
21499-23-0 CAS number cross-checked
Molecular formula
C16H14O5
UNII
9DDW04R41V
MDL number
MFCD00210357
InChIKey
PBILBHLAPJTJOT-CQSZACIVSA-N
InChI
InChI=1S/C16H14O5/c1-20-13-6-5-9(7-12(13)18)14-8-10-3-2-4-11(17)15(10)16(19)21-14/h2-7,14,17-18H,8H2,1H3/t14-/m1/s1
Canonical SMILES
COc1ccc(C2Cc3cccc(O)c3C(=O)O2)cc1O
Isomeric SMILES
COC1=C(C=C(C=C1)[C@H]2CC3=C(C(=CC=C3)O)C(=O)O2)O

Synonyms

  • d-Phyllodulcin
  • (3R)-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-3,4-dihydroisochromen-1-one
  • (3R)-8-hydroxy-3-(3-hydroxy-4-methoxy-phenyl)isochroman-1-one
  • 1H-2-Benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-, (R)-
  • (+)-Phyllodulcin
  • (R)-8-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)isochroman-1-one
  • (3R)-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-1H-2-benzopyran-1-one
  • (R)-3,4-Dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one
  • Ambap21499-23-0
  • (3R)-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-1H-isochromen-1-one
  • (3R)-3,4-Dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
286.28 g/molcalc.
Exact mass
286.0841 Dacalc.
LogP (octanol/water)
2.56calc.
Topological polar surface area
75.99 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.19calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1OC(c2ccccc2)Cc2ccccc21

O=C1OC(c2ccccc2)Cc2ccccc21

3 rings, 17 atoms, the 3-Phenyl-1-oxoisochroman ring system.

33 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Phyllodulcin suppliers

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Where suppliers are based

1 supplier in 1 country

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Phyllodulcin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Sweetening Agents

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Phyllodulcin is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Phyllodulcin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Phyllodulcin, based on the data on this page

What is Phyllodulcin?

Phyllodulcin is a hydroxybenzoic acid.

What is the CAS number of Phyllodulcin?

The CAS registry number of Phyllodulcin is 21499-23-0.

What is the molecular formula and weight of Phyllodulcin?

The molecular formula of Phyllodulcin is C16H14O5 and its molar mass is 286.28 g/mol.

What is Phyllodulcin used for?

Known uses and roles of Phyllodulcin include sweeteners in food and beverage and sweetening agents.

Is Phyllodulcin hazardous?

No GHS hazard classification for Phyllodulcin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Phyllodulcin?

Phyllodulcin is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Phyllodulcin?

CompoundList lists 1 supplier of Phyllodulcin in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Phyllodulcin?

Suppliers quote Phyllodulcin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Phyllodulcin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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