Piperazine

Veterinary medication:.

Piperazine is used as a scruber in gas-washer formulations, as a hardener for glue prepolymers, as an intermediate in the preparation of hydroxyethyl piperazine, N,N'-dimethyl piperazine, and N-methyl piperazine, and as a raw material to prepare intermediates used for antihistamine production. Piperazine salts are human and veterinary medicinal drugs used as anthelmintics.

In mfg of ... corrosion inhibitors, surface-active agents.

Industrial uses: Intermediate.

Use classes: Pharmaceuticals.

Piperazine is a cyclic organic compound possessing two nitrogen atoms in opposite positions within a 6-member heterocyclic ring that serves as a backbone for piperazine derivatives and acts as a gamma-amino-butyric acid (GABA) receptor agonist in nematodes, with potential anti-helminthic activity. Upon administration, piperazine binds to the GABA inhibitory receptors in susceptible nematodes, thereby inducing chloride channel opening and hyperpolarization.

Condensation & de-amination of diethylenetriamine, condensation of diethanolamine in the presence of ammonia, condensation & dehydration of monethanolamine

The ethanol amine based process: Piperazine is synthesized by reaction of ethanolamine with ammonia under high pressure over a catalyst in the presence of hydrogen to produce a mixture of ethylene amines, e.g. piperazine, as well as water as by-product. The ethyleneamines are separated via distillation. Sometimes this process is integrated with the ethanolamine process.