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Synthetic aroma chemicals

Piperonal

Also known as Heliotropin, Heliotropine, Piperonyl aldehyde

CAS 120-57-0Formula C8H6O3Molar mass 150.13 g/molEC 204-409-7
GHS signal word: Warning. Pictograms: Harmful or irritant Controlled, licensed buyers only
Request as a licensed buyer Safety data
Piperonal chemical structure, C8H6O3, CAS 120-57-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless, lustrous crystals
Melting point
37 °C
Boiling point
263 °C
Solubility
In water, 3.5 × 10⁺³ mg/L at 20 °C
HS code
293293
Category
Synthetic aroma chemicals

What is Piperonal?

Plain description, key identifiers and synonyms

Piperonal is an arenecarbaldehyde that is 1,3-benzodioxole substituted by a formyl substituent at position 5. It has been isolated from Piper nigrum. It has a role as a fragrance, an insect repellent and a plant metabolite. It is an arenecarbaldehyde and a member of benzodioxoles.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1,3-benzodioxole-5-carbaldehyde
CAS number
120-57-0 CAS number cross-checkedOther or deprecated CAS: 30024-74-9
EC number
204-409-7
Molecular formula
C8H6O3
UNII
KE109YAK00
INCI name
HELIOTROPINE
InChIKey
SATCULPHIDQDRE-UHFFFAOYSA-N
InChI
InChI=1S/C8H6O3/c9-4-6-1-2-7-8(3-6)11-5-10-7/h1-4H,5H2
SMILES (canonical and isomeric)
C1OC2=C(O1)C=C(C=C2)C=O

Synonyms

  • Heliotropin
  • Heliotropine
  • Piperonyl aldehyde
  • Piperonaldehyde
  • 1,3-Benzodioxole-5-carbaldehyde
  • Piperonylaldehyde
  • Geliotropin
  • 3,4-Methylenedioxybenzaldehyde
  • 1,3-Benzodioxole-5-carboxaldehyde
  • 3,4-(Methylenedioxy)benzaldehyde
  • 5-Formyl-1,3-benzodioxole
  • Protocatechuic aldehyde methylene ether
  • 3,4-Dihydroxybenzaldehyde methylene ketal
  • 3,4-Dimethylenedioxybenzaldehyde
  • 2H-1,3-Benzodioxole-5-Carbaldehyde
  • Dioxymethylene protocatechuic aldehyde
  • Benzaldehyde, 3,4-(methylenedioxy)-
  • Dioxymethyleneprotocatechuic aldehyde
  • heliotrin
  • Benzo[D][1,3]Dioxole-5-Carbaldehyde
  • 3,4-Bis(methylenedioxy)benzaldehyde
  • Dioxymethylene-protocatechuic aldehyde
  • 3,4-Methylene-dihydroxybenzaldehyde
  • 3,4-methylenedioxy-benzaldehyde
  • 3,4-Methylen-dioxy-benzaldehyde
Show all 35 synonyms
  • benzo[1,3]dioxole-5-carbaldehyde
  • Heliotropin (natural)
  • 2H-benzo[d]1,3-dioxolane-5-carbaldehyde
  • Controlled Substance<br>(Tadalafil Impurity H)
  • Piperonale
  • Piperanal
  • Blue P
  • Piperonal, 8CI
  • Piperonal, 99%
  • Heliotropine (piperonal)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless, lustrous crystalsexp.
Odour
Heliotrope odorexp.
Taste
Bittersweet tasteexp.
Melting point
37 °Cexp.
Boiling point
263 °Cexp.
Solubility
In water, 3.5 × 10⁺³ mg/L at 20 °Cexp.
Vapour pressure
1 × 10⁻² mm Hg at 25 °C (extrapolated)exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
150.13 g/molcalc.
Exact mass
150.0317 Dacalc.
LogP (octanol/water)
1.23calc.
Topological polar surface area
35.53 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
11calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.13calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)OCO2

c1ccc2c(c1)OCO2

2 rings, 9 atoms, the 1,3-Benzodioxole ring system.

4,560 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H317May cause an allergic skin reaction.
Precautionary statements (8)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Piperonal suppliers

Controlled substance, listings of documented suppliers only, in the documented ranking

Drug precursor

Piperonal is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.

Licensed buyers only, every enquiry is reviewed by our compliance team.

Reference: UN Convention against Illicit Traffic 1988 Table I, India NDPS controlled substance, HS 2022 subheading 2932.93 (piperonal)

Our policy on controlled substances
No documented supplier lists it yet

Licensed buyers can post a request for Piperonal with their licence. Our compliance team reviews it before suppliers see it.

Request as a licensed buyer

Piperonal price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Reported uses (ppm):

Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association, 1994) [Table#1679].

Has been used as pediculicide.

Perfumery, suntan preparations, mosquito repellent, laboratory reagent, flavoring.

In perfumery, in cherry and vanilla flavors, in organic syntheses.

Industrial uses: Flavoring and nutrient, Fragrance.

Consumer uses: Fragrance.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name HELIOTROPINE(fragrance, perfuming)

Roles

  • eukaryotic metabolite
  • fragrance
  • insect repellent
  • insecticide
  • metabolite
  • pesticide
  • plant metabolite

Functional uses

  • Deodorizer
  • Flavouring and nutrient
  • Fragrance
  • Softener and conditioner

Cosmetic functions

  • Fragrance
  • Perfuming

How it is made

Piperonal (3,4-methylenedioxybenzaldehyde) is prepared in 94% yield via ozonolysis and reduction of isosafrole.

By the oxidation of isosafrole with potassium dichromate and sulfuric acid and subsequent steam distillation of piperonal.

Derivation: By oxidation of isosafrole.

Regulatory status

Inventories, regulations and trade controls that list this substance

Drug precursor

Piperonal is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.

Licensed buyers only, every enquiry is reviewed by our compliance team.

Reference: UN Convention against Illicit Traffic 1988 Table I, India NDPS controlled substance, HS 2022 subheading 2932.93 (piperonal)

Our policy on controlled substances

Health and food

  • EU cosmetic ingredient inventory

Controls

  • US DEA controlled substance or listed chemical
  • Drug precursor (UN 1988 Convention)

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Piperonal is traded under.

HS 2932.93Exact HS code

Heterocyclic compounds: with oxygen hetero-atom(s) only, (other than lactones or compounds containing an…

World exports in 2024
$38.5M
+7.4% vs 2023, imports $38.4M
2019 to 2024
Top exporters
  1. China75.6%
  2. Germany7.8%
  3. Hong Kong5.8%
Top importers
  1. United States22.5%
  2. Germany12.0%
  3. India * partner reported7.2%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Piperonal is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Piperonal, based on the data on this page

What is Piperonal?

Piperonal is an arenecarbaldehyde that is 1,3-benzodioxole substituted by a formyl substituent at position 5. It has been isolated from Piper nigrum. It has a role as a fragrance, an insect repellent and a plant metabolite. It is an arenecarbaldehyde and a member of benzodioxoles.

What is the CAS number of Piperonal?

The CAS registry number of Piperonal is 120-57-0. Other or deprecated CAS numbers: 30024-74-9.

What is the molecular formula and weight of Piperonal?

The molecular formula of Piperonal is C8H6O3 and its molar mass is 150.13 g/mol.

What is Piperonal used for?

Reported uses (ppm): Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association, 1994) [Table#1679]. Has been used as pediculicide. Perfumery, suntan preparations, mosquito repellent, laboratory reagent, flavoring. In perfumery, in cherry and vanilla flavors, in organic syntheses.

Is Piperonal hazardous?

Piperonal carries the GHS signal word "Warning". Main hazards: may cause an allergic skin reaction. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Piperonal?

Piperonal is usually classified under HS code 293293 (Piperonal). This is indicative, confirm it with your customs broker before shipping.

Can I buy Piperonal on CompoundList?

Piperonal is a controlled substance. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed by our compliance team before suppliers see it.

Guides for buyers

Practical guides that help when you source, ship or handle Piperonal

Request as a licensed buyer

Upload your licence with the request. Our compliance team reviews it before the documented suppliers see it.
Request as a licensed buyer
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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