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Buffers and biological buffers

Pipes

Also known as 1,4-Piperazinediethanesulfonic acid, Piperazine-N,N'-bis(2-ethanesulfonic acid), 1,4-Piperazinebis(ethanesulfonic acid)

CAS 5625-37-6Formula C8H18N2O6S2Molar mass 302.37 g/molEC 227-057-6
18 suppliers listed
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Pipes chemical structure, C8H18N2O6S2, CAS 5625-37-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
5625-37-6
Formula
C8H18N2O6S2
Molar mass
302.37 g/mol
EC number
227-057-6
HS code
293359
Category
Buffers and biological buffers

What is Pipes?

Plain description, key identifiers and synonyms

2,2'-piperazine-1,4-diylbisethanesulfonic acid is a Good's buffer substance, pKa = 6.8 at 20 C. It is a conjugate acid of a 2,2'-piperazine-1,4-diylbisethanesulfonate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[4-(2-sulfoethyl)piperazin-1-yl]ethanesulfonic acid
CAS number
5625-37-6 CAS number cross-checked
EC number
227-057-6
Molecular formula
C8H18N2O6S2
UNII
G502H79V6L
MDL number
MFCD00006159
InChIKey
IHPYMWDTONKSCO-UHFFFAOYSA-N
InChI
InChI=1S/C8H18N2O6S2/c11-17(12,13)7-5-9-1-2-10(4-3-9)6-8-18(14,15)16/h1-8H2,(H,11,12,13)(H,14,15,16)
SMILES (canonical and isomeric)
C1CN(CCN1CCS(=O)(=O)O)CCS(=O)(=O)O

Synonyms

  • 1,4-Piperazinediethanesulfonic acid
  • Piperazine-N,N'-bis(2-ethanesulfonic acid)
  • 1,4-Piperazinebis(ethanesulfonic acid)
  • 2,2'-(Piperazine-1,4-diyl)bis(ethanesulphonic) acid
  • Piperazine-N,N'-bis[2-ethanesulfonic acid]
  • 1,4-piperazineethanesulfonate
  • 1,4Piperazinediethanesulfonic acid
  • 1,4-piperazinediethanesulphonic acid
  • 1,4-piperazinediethane sulfonic acid
  • 1,4Piperazinebis(ethanesulfonic acid)
  • PiperazineN,N'bis(2ethanesulfonic acid)
  • 2,2'(Piperazine1,4diyl)bis(ethanesulphonic) acid
  • piperazine-N,N'-bis(2-ethanesulfonic acid), sodium salt
  • 2,2'-(Piperazine-1,4-diyl)diethanesulfonic acid
  • 2-[4-(2-sulfoethyl)piperazin-1-yl]ethanesulfonic acid
  • 2,2'-piperazine-1,4-diylbisethanesulfonic acid
  • Piperazine-N,N-bis(2-ethanesulfonic acid)
  • disodium PIPES
  • 2,2'-piperazine-1,4-diyldiethanesulfonic acid
  • 2,2'-(Piperazine-1,4-diyl)diethanesulfonicacid
  • 1,4-Piperazinediethanesulfonic acid, 1,4-Piperazine bis(ethanesulfonic acid), NSC 157117
  • 1,4-Piperazinediethanesulfonic acid(PIPES)
  • Piperazine-N,N -bis[2-ethanesulfonic acid]
  • 1,4-piperazinebis(ethanesulphonic acid)
  • 2-[4-(2-sulfoethyl)piperazinyl]ethanesulfonic acid
Show all 36 synonyms
  • piperazine-N
  • Piperazine-1,4-bisethanesulfonic acid
  • 1,4-piperazine bis(ethanesulfonic acid)
  • Piperazine-1,4-bis(2-ethanesulfonic acid)
  • PIPES Buffered Solution
  • piperazine-n,n'-bis-(2-ethanesulphonic acid)
  • PIPES, >=99% (titration)
  • 2-[4-(2-sulfoethyl)piperazin-1-yl]ethane-1-sulfonic acid
  • PIPES, BioXtra, >=99% (titration)
  • Piperazine-N,N`-bis(2-ethanesulfonic acid)
  • PIPES, Vetec(TM) reagent grade, >=99%

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
302.37 g/molcalc.
Exact mass
302.0606 Dacalc.
LogP (octanol/water)
-1.62calc.
Topological polar surface area
115.2 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
6calc.
Heavy atoms
18calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CNCCN1

C1CNCCN1

1 ring, 6 atoms, the Piperazine ring system.

6,832 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Pipes suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 18 suppliers
18 of 18 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

18 suppliers in 3 countries

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Pipes price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Roles

  • Good's buffer substance
  • buffer

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Pipes is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Pipes is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Pipes, based on the data on this page

What is Pipes?

2,2'-piperazine-1,4-diylbisethanesulfonic acid is a Good's buffer substance, pKa = 6.8 at 20 C. It is a conjugate acid of a 2,2'-piperazine-1,4-diylbisethanesulfonate.

What is the CAS number of Pipes?

The CAS registry number of Pipes is 5625-37-6.

What is the molecular formula and weight of Pipes?

The molecular formula of Pipes is C8H18N2O6S2 and its molar mass is 302.37 g/mol.

What is Pipes used for?

Known uses and roles of Pipes include buffers in research and laboratory, good's buffer substance and buffer.

Is Pipes hazardous?

No GHS hazard classification for Pipes is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Pipes?

Pipes is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Pipes?

CompoundList lists 18 suppliers of Pipes in China, United States and Germany. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Pipes?

Suppliers quote Pipes on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Pipes

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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