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Central nervous system drugs

Pramoxine

Also known as Pramocaine, Proxazocain, 4-[3-(4-Butoxyphenoxy)propyl]morpholine

CAS 140-65-8Formula C17H27NO3Molar mass 293.41 g/molEC 205-425-7
1 supplier listed Drug substance
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Pramoxine chemical structure, C17H27NO3, CAS 140-65-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
140-65-8
Formula
C17H27NO3
Molar mass
293.41 g/mol
EC number
205-425-7
HS code
293499
Category
Central nervous system drugs

What is Pramoxine?

Plain description, key identifiers and synonyms

Pramocaine is a member of the class of morpholines that is morpholine substituted at the nitrogen atom by a 3-(4-butoxyphenoxy)propyl group. It has a role as a local anaesthetic. It is an aromatic ether and a member of morpholines.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[3-(4-butoxyphenoxy)propyl]morpholine
CAS number
140-65-8 CAS number cross-checked
EC number
205-425-7
Molecular formula
C17H27NO3
UNII
068X84E056
InChIKey
DQKXQSGTHWVTAD-UHFFFAOYSA-N
InChI
InChI=1S/C17H27NO3/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18/h5-8H,2-4,9-15H2,1H3
SMILES (canonical and isomeric)
CCCCOC1=CC=C(C=C1)OCCCN2CCOCC2

Synonyms

  • Pramocaine
  • Proxazocain
  • 4-[3-(4-Butoxyphenoxy)propyl]morpholine
  • pramocainum
  • Pramocaina
  • 4-(3-(p-Butoxyphenoxy)propyl)morpholine
  • p-Butoxyphenyl gamma-morpholinopropyl ether
  • gamma-Morpholinopropyl 4-n-butoxyphenyl ether
  • 4-(3-(4-butoxyphenoxy)propyl)morpholine
  • Tronopthane
  • Morpholine, 4-(3-(p-butoxyphenoxy)propyl)-
  • Pramocaine (INN)
  • Morpholine, 4-[3-(4-butoxyphenoxy)propyl]-
  • 4-27-00-00127 (Beilstein Handbook Reference)
  • DivK1c_000882
  • 4-[3-(4-Butoxyphenoxy)propyl]morpholine #
  • Morpholine,4-[3-(4-butoxyphenoxy)propyl]-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
293.41 g/molcalc.
Exact mass
293.1991 Dacalc.
LogP (octanol/water)
2.97calc.
Topological polar surface area
30.93 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
9calc.
Heavy atoms
21calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.65calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(OCCCN2CCOCC2)cc1

c1ccc(OCCCN2CCOCC2)cc1

2 rings, 16 atoms, the 4-(3-Phenoxypropyl)morpholine ring system.

202 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Pramoxine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

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  • Leapchem
    China, Hong KongUnclaimed profile
    PramoxineGrade, purity and minimum order on request
    Price on request
    View

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Where suppliers are based

1 supplier in 1 country

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Pramoxine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Anesthetics, Local

Roles

  • anaesthetic
  • local anaesthetic
  • pharmaceutical

Pharmacology

Pramocaine is a morpholine derivative with local anesthetic property. Pramocaine decreases the permeability of the neuronal membrane to sodium ions by reversibly binding to and inhibiting voltage-gated sodium channels. This results in stabilization of the membrane and, thereby inhibiting the ionic fluxes required for membrane depolarization, hence resulting in the failure to initiate a propagated action potential and subsequent conduction blockade.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Pramocaine (INN), Ref no: 405, Annex ref: II/405
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Pramoxine is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Pramoxine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Pramoxine, based on the data on this page

What is Pramoxine?

Pramocaine is a member of the class of morpholines that is morpholine substituted at the nitrogen atom by a 3-(4-butoxyphenoxy)propyl group. It has a role as a local anaesthetic. It is an aromatic ether and a member of morpholines.

What is the CAS number of Pramoxine?

The CAS registry number of Pramoxine is 140-65-8.

What is the molecular formula and weight of Pramoxine?

The molecular formula of Pramoxine is C17H27NO3 and its molar mass is 293.41 g/mol.

What is Pramoxine used for?

Use classes: Pharmaceuticals.

Is Pramoxine hazardous?

No GHS hazard classification for Pramoxine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Pramoxine?

Pramoxine is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Pramoxine?

CompoundList lists 1 supplier of Pramoxine in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Pramoxine?

Suppliers quote Pramoxine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Pramoxine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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