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Antibiotics and anti-infectives

Primaquine diphosphate

Also known as Primaquine phosphate, Malquine, 1,4-Pentanediamine, N4-(6-methoxy-8-quinolinyl)-, phosphate (1:2)

CAS 63-45-6Formula C15H27N3O9P2Molar mass 455.34 g/molEC 200-560-8
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 79 suppliers listed Drug substance
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Primaquine diphosphate chemical structure, C15H27N3O9P2, CAS 63-45-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
63-45-6
Formula
C15H27N3O9P2
Molar mass
455.34 g/mol
EC number
200-560-8
HS code
293349
Category
Antibiotics and anti-infectives

What is Primaquine diphosphate?

Plain description, key identifiers and synonyms

Primaquine Phosphate is the phosphate salt form of primaquine, a synthetic, 8-aminoquinoline derivative with antimalarial properties. Although its mechanism of action is unclear, primaquine bind to and alter the properties of protozoal DNA. This agent eliminates tissue (exo-erythrocytic) malarial infection, preventing the development of the erythrocytic forms of the parasite which are responsible for relapses in Plasmodium vivax and ovale malaria. Primaquine is active against late hepatic stages (hypnozoites, schizonts).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine, phosphoric acid
CAS number
63-45-6 CAS number cross-checked
EC number
200-560-8
Molecular formula
C15H27N3O9P2
UNII
H0982HF78B
MDL number
MFCD00013166
InChIKey
GJOHLWZHWQUKAU-UHFFFAOYSA-N
InChI
InChI=1S/C15H21N3O.2H3O4P/c1-11(5-3-7-16)18-14-10-13(19-2)9-12-6-4-8-17-15(12)14;2*1-5(2,3)4/h4,6,8-11,18H,3,5,7,16H2,1-2H3;2*(H3,1,2,3,4)
SMILES (canonical and isomeric)
CC(CCCN)NC1=C2C(=CC(=C1)OC)C=CC=N2.OP(=O)(O)O.OP(=O)(O)O

Synonyms

  • Primaquine phosphate
  • Malquine
  • 1,4-Pentanediamine, N4-(6-methoxy-8-quinolinyl)-, phosphate (1:2)
  • Camden
  • Primaquini diphosphas
  • WR 2975
  • Diphosphate, Primaquine
  • Phosphate, Primaquine
  • Primaquine bisphosphate
  • Primaquine (Diphosphate)
  • N4-(6-methoxyquinolin-8-yl)pentane-1,4-diamine bis(phosphate)
  • Primaquine phosphate, Primaquine bisphosphate
  • 4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine, phosphoric acid
  • N-(5-aminopentan-2-yl)-6-methoxyquinolin-8-amine, bis(phosphoric acid)
  • Primaquine Diphosphate (>90%)
  • Primaquine bis(phosphate)
  • Primachina,
  • Primaquina,
  • Primaquinum,
  • Primachin,
  • Primaquin,
  • SN13272 diphosphate
  • 8-((4-Amino-1-methylbutyl)amino)-6-methoxyquinoline diphosphate
  • 8-((4-Amino-1-methylbutyl)amino)-6-methoxyquinoline phosphate (1:2)
  • Primaquine diphosphate CRS
Show all 29 synonyms
  • Primaquine bisphosphate, 98%
  • Primaquine phosphate (JAN/USP)
  • 8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline diphosphate
  • Primaquine (diphosphate) (Standard)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
455.34 g/molcalc.
Exact mass
455.1223 Dacalc.
LogP (octanol/water)
0.93calc.
Topological polar surface area
215.7 Ųcalc.
Hydrogen bond donors
8calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
6calc.
Heavy atoms
29calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.4calc.
Formal charge
0calc.
Stereocentres
1calc.
Components
3calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2ncccc2c1

c1ccc2ncccc2c1

2 rings, 10 atoms, the Quinoline ring system.

21,766 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Primaquine diphosphate suppliers

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All 79 suppliers
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Where suppliers are based

79 suppliers in 12 countries

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Primaquine diphosphate price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antiinfective agent
  • antimalarial
  • antimicrobial agent
  • antimicrobial drug
  • antiparasitic agent
  • antiplasmodial drug
  • antiprotozoal drug
  • pharmaceutical

Pharmacology

Primaquine Phosphate is the phosphate salt form of primaquine, a synthetic, 8-aminoquinoline derivative with antimalarial properties. Although its mechanism of action is unclear, primaquine bind to and alter the properties of protozoal DNA. This agent eliminates tissue (exo-erythrocytic) malarial infection, preventing the development of the erythrocytic forms of the parasite which are responsible for relapses in Plasmodium vivax and ovale malaria. Primaquine is active against late hepatic stages (hypnozoites, schizonts).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Primaquine diphosphate is traded under.

HS 2933.49Indicative HS code

Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…

World exports in 2024
$939M
−14.6% vs 2023, imports $1.48B
2019 to 2024
Top exporters
  1. China30.1%
  2. India * partner reported16.7%
  3. Switzerland * partner reported14.1%
Top importers
  1. United Kingdom19.2%
  2. Germany16.0%
  3. Romania8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Primaquine diphosphate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Primaquine diphosphate, based on the data on this page

What is Primaquine diphosphate?

Primaquine Phosphate is the phosphate salt form of primaquine, a synthetic, 8-aminoquinoline derivative with antimalarial properties. Although its mechanism of action is unclear, primaquine bind to and alter the properties of protozoal DNA.

What is the CAS number of Primaquine diphosphate?

The CAS registry number of Primaquine diphosphate is 63-45-6.

What is the molecular formula and weight of Primaquine diphosphate?

The molecular formula of Primaquine diphosphate is C15H27N3O9P2 and its molar mass is 455.34 g/mol.

What is Primaquine diphosphate used for?

Known uses and roles of Primaquine diphosphate include antiinfective agent, antimalarial, antimicrobial agent, antimicrobial drug, antiparasitic agent and 3 more.

Is Primaquine diphosphate hazardous?

Primaquine diphosphate carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Primaquine diphosphate?

Primaquine diphosphate is usually classified under HS code 293349 (Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Primaquine diphosphate?

CompoundList lists 79 suppliers of Primaquine diphosphate in United States, China, India, Germany and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Primaquine diphosphate in India?

6 suppliers in India list Primaquine diphosphate on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Primaquine diphosphate?

Suppliers quote Primaquine diphosphate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Primaquine diphosphate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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