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Other active pharmaceutical ingredients

Probenecid

Also known as 4-(Dipropylsulfamoyl)benzoic acid, Benemid, Probenecid acid

CAS 57-66-9Formula C13H19NO4SMolar mass 285.37 g/molEC 200-344-3
GHS signal word: Warning. Pictograms: Harmful or irritant 90 suppliers listed Drug substance
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Probenecid chemical structure, C13H19NO4S, CAS 57-66-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from dil alcohol
Melting point
194 to 196
Solubility
FREELY SOL IN WATER /SODIUM SALT/
HS code
293590
Category
Other active pharmaceutical ingredients
UN number
UN 3249
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Probenecid?

Plain description, key identifiers and synonyms

Probenecid is a sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups. It has a role as a uricosuric drug. It is a member of benzoic acids and a sulfonamide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-(dipropylsulfamoyl)benzoic acid
CAS number
57-66-9 CAS number cross-checked
EC number
200-344-3
Molecular formula
C13H19NO4S
UNII
PO572Z7917
MDL number
MFCD00038402
InChIKey
DBABZHXKTCFAPX-UHFFFAOYSA-N
InChI
InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
SMILES (canonical and isomeric)
CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O

Synonyms

  • 4-(Dipropylsulfamoyl)benzoic acid
  • Benemid
  • Probenecid acid
  • Probecid
  • Benecid
  • Apurina
  • Benuryl
  • p-(Dipropylsulfamoyl)benzoic acid
  • Probalan
  • Probenemid
  • Prolongine
  • Tubophan
  • Uricosid
  • Proben
  • Synergid R
  • Probenecide
  • Probenecidum
  • 4-[(dipropylamino)sulfonyl]benzoic acid
  • Probenecida
  • 4-((Dipropylamino)sulfonyl)benzoic acid
  • Probenate
  • 4-(Di-n-propylsulfamoyl)benzoesaeure
  • Benzoic acid, p-(dipropylsulfamoyl)-
  • 4-(N,N-Dipropylsulfamoyl)benzoesaeure
  • Benzoic acid, 4-[(dipropylamino)sulfonyl]-
Show all 38 synonyms
  • p-(Dipropylsulfamyl)benzoic acid
  • Benzoic acid, 4-((dipropylamino)sulfonyl)-
  • p-[Dipropylsulfamoyl]benzoic acid
  • 4-11-00-00691 (Beilstein Handbook Reference)
  • Orlynvah component probenecid
  • Probampicin
  • SK-Probenecid
  • 4-(Dipropylaminosulfonyl)benzoic acid
  • probenate (see under pivampicillin)
  • Probexin
  • 4-(N,N-Dipropylsulfamoyl)benzoic Acid
  • Probenecid (Standard)
  • 4-Dipropylsulfamoyl-benzoic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from dil alcoholexp.
Odour
PRACTICALLY ODORLESSexp.
Taste
SLIGHTLY BITTER, PLEASANT AFTERTASTEexp.
Melting point
194 to 196exp.
Solubility
FREELY SOL IN WATER /SODIUM SALT/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
285.37 g/molcalc.
Exact mass
285.1035 Dacalc.
LogP (octanol/water)
2.2calc.
Topological polar surface area
74.68 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
7calc.
Heavy atoms
19calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.46calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 3249

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Probenecid suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 90 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

90 suppliers in 16 countries

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Probenecid price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Adjuvants, Pharmaceutic
  • Uricosuric Agents

Roles

  • anti-obesity agent
  • antibacterial agent
  • antiinfective agent
  • antimicrobial agent
  • antineoplastic agent
  • antirheumatic drug
  • antiviral agent
  • cardiovascular drug
  • gout suppressant
  • hypoglycemic agent
  • neuroprotective agent
  • pharmaceutical
  • protective agent
  • renal agent
  • renoprotective agent
  • uricosuric drug

Pharmacology

Probenecid is a benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration.

How it is made

Reaction of toluene with chlorosulfonic acid followed by hydrolysis and oxidation yields p-carboxybenzenesulfonicacid, then treatment of this acid with chlorosulfonic acid and condensation with di-n-propylamine

Preparation from p-carboxybenzenesulfonyl chloride & dipropylamine.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Probenecid (INN), Ref no: 161, Annex ref: II/161
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Probenecid is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Probenecid is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Probenecid, based on the data on this page

What is Probenecid?

Probenecid is a sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups. It has a role as a uricosuric drug. It is a member of benzoic acids and a sulfonamide.

What is the CAS number of Probenecid?

The CAS registry number of Probenecid is 57-66-9.

What is the molecular formula and weight of Probenecid?

The molecular formula of Probenecid is C13H19NO4S and its molar mass is 285.37 g/mol.

What is Probenecid used for?

Use classes: Pharmaceuticals.

Is Probenecid hazardous?

Probenecid carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Probenecid?

Probenecid is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Probenecid?

CompoundList lists 90 suppliers of Probenecid in United States, China, India, Germany and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Probenecid in India?

7 suppliers in India list Probenecid on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Probenecid?

Suppliers quote Probenecid on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Probenecid

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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