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Disinfectants and oxidizers

Proflavine

Also known as acridine-3,6-diamine, Proflavin, 3,6-Acridinediamine

CAS 92-62-6Formula C13H11N3Molar mass 209.25 g/molEC 202-172-4
GHS signal word: Warning. Pictograms: Harmful or irritant 22 suppliers listed
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Proflavine chemical structure, C13H11N3, CAS 92-62-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Yellow needles from alcohol. Solutions are brownish and when diluted are fluorescent
Melting point
284 to 286
Solubility
Red needles, hygroscopic. Sol in 300 parts cold water, in 1 part boiling water, slightly…
HS code
293399
Category
Disinfectants and oxidizers
Illustrative photo, yellow pigment powder in an open fibre drum in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Proflavine?

Plain description, key identifiers and synonyms

3,6-diaminoacridine is an aminoacridine that is acridine that is substituted by amino groups at positions 3 and 6. A slow-acting bacteriostat that is effective against many Gram-positive bacteria (but ineffective against spores), its salts were formerly used for treatment of burns and infected wounds. It has a role as a chromophore, an intercalator, an antibacterial agent, an antiseptic drug and a carcinogenic agent. It is a conjugate base of a 3,6-diaminoacridine(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
acridine-3,6-diamine
CAS number
92-62-6 CAS number cross-checked
EC number
202-172-4
Molecular formula
C13H11N3
UNII
CY3RNB3K4T
MDL number
MFCD00005030
InChIKey
WDVSHHCDHLJJJR-UHFFFAOYSA-N
InChI
InChI=1S/C13H11N3/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10/h1-7H,14-15H2
SMILES (canonical and isomeric)
C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N

Synonyms

  • acridine-3,6-diamine
  • Proflavin
  • 3,6-Acridinediamine
  • 3,6-Diaminoacridine
  • Isoflav base
  • Proflavina
  • Proflavinum
  • 2,8-Diaminoacridinium
  • 2,8-Diaminoacridine
  • 3,6-Diaminoacridinium
  • Diaminoacridine
  • 3,6 diaminoacridine
  • 3,6-diamino acridine
  • 3,6 Diamino Acridine
  • Acridine, 3,6-Diamino
  • Acridine, 3,6-diamino-
  • 3,7-Diamino-5-azaanthracene
  • Proflavine (hemisulfate)
  • Profura
  • Progarmed
  • PRL
  • Proflavin hemisulfate, 3,6-Diaminoacridine hemisulfate
  • 2,8-Diaminoacridine (European)
  • (6-aminoacridin-3-yl)amine, sulfuric acid, hydrate
  • acridine-3,6-diamine, sulfuric acid, hydrate
Show all 31 synonyms
  • 1bcu
  • 1qvt
  • 1qvu
  • 3,6-Acridinediamine hydrochloride
  • 3,6-diaminoacridin
  • proflavine-hemisulfate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Yellow needles from alcohol. Solutions are brownish and when diluted are fluorescentexp.
Melting point
284 to 286exp.
Solubility
Red needles, hygroscopic. Sol in 300 parts cold water, in 1 part boiling water, slightly sol in alc. Practically insol in ether. pH of satd soln is 6-8. pH of 0.1 percent soln is 2.5 /Sulfate/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
209.25 g/molcalc.
Exact mass
209.0953 Dacalc.
LogP (octanol/water)
2.55calc.
Topological polar surface area
64.93 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
0calc.
Heavy atoms
16calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2nc3ccccc3cc2c1

c1ccc2nc3ccccc3cc2c1

3 rings, 14 atoms, the Acridine ring system.

1,068 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Proflavine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 22 suppliers
22 of 22 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

22 suppliers in 8 countries

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Proflavine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

The survival of Salmonella dublin exposed to visible sunlight, and heterotrophic bacteria in freshwater microcosms in the presence and absence of the photosensitizer proflavine, was studied. Enumeration of S. dublin and the heterotrophic bacteria showed that in both illuminated and nonilluminated systems (without proflavine) the bacteria remained viable and culturable for at least 6 days. The optimal proflavine concentration (no effect in the dark and a maximal photoinactivation of salmonellae after irradiation) was 2 mg l(-1). In contrast to S. dublin, the heterotrophic bacteria overcame the initial inhibitory effect of proflavine. The possible use of photosterilization against contamination with pathogenic bacteria in water model ecosystems, is discussed.

Pharmacological actions

  • Anti-Infective Agents, Local

Roles

  • aetiopathogenetic role
  • antibacterial agent
  • antiinfective agent
  • antimicrobial agent
  • antineoplastic agent
  • antiseptic drug
  • carcinogenic agent
  • chromophore
  • genotoxin
  • intercalator
  • mutagen
  • pharmaceutical
  • photochemical role

How it is made

Prepn: M. Schopff, Ber. 27, 2320 (1984), DE 230412 (1910 to Cassella), C.A. 5, 2734 (1911), W.P. Thompson, GB 137214 (1919 to Poulenc Freres), C.A. 14, 1445 (1920)

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Inactive in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Proflavine is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Proflavine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Proflavine, based on the data on this page

What is Proflavine?

3,6-diaminoacridine is an aminoacridine that is acridine that is substituted by amino groups at positions 3 and 6. A slow-acting bacteriostat that is effective against many Gram-positive bacteria (but ineffective against spores), its salts were formerly used for treatment of burns and infected wounds.

What is the CAS number of Proflavine?

The CAS registry number of Proflavine is 92-62-6.

What is the molecular formula and weight of Proflavine?

The molecular formula of Proflavine is C13H11N3 and its molar mass is 209.25 g/mol.

What is Proflavine used for?

The survival of Salmonella dublin exposed to visible sunlight, and heterotrophic bacteria in freshwater microcosms in the presence and absence of the photosensitizer proflavine, was studied. Enumeration of S.

Is Proflavine hazardous?

Proflavine carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Proflavine?

Proflavine is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Proflavine?

CompoundList lists 22 suppliers of Proflavine in United States, China, Hong Kong, United Kingdom and 4 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Proflavine?

Suppliers quote Proflavine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Proflavine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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