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Antibiotics and anti-infectives

Proguanil

Also known as Chloroguanide, Chlorguanide, Bigumal

CAS 500-92-5Formula C11H16ClN5Molar mass 253.74 g/molEC 207-915-6
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Proguanil chemical structure, C11H16ClN5, CAS 500-92-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
500-92-5
Formula
C11H16ClN5
Molar mass
253.74 g/mol
EC number
207-915-6
HS code
292529
Category
Antibiotics and anti-infectives

What is Proguanil?

Plain description, key identifiers and synonyms

Proguanil is a biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells. It has a role as an antiprotozoal drug, an antimalarial and an EC 1.5.1.3 (dihydrofolate reductase) inhibitor. It is a member of biguanides and a member of monochlorobenzenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1E)-1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine
CAS number
500-92-5 CAS number cross-checked
EC number
207-915-6
Molecular formula
C11H16ClN5
UNII
S61K3P7B2V
InChIKey
SSOLNOMRVKKSON-UHFFFAOYSA-N
InChI
InChI=1S/C11H16ClN5/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9/h3-7H,1-2H3,(H5,13,14,15,16,17)
Canonical SMILES
CC(C)N=C(N)N=C(N)Nc1ccc(Cl)cc1
Isomeric SMILES
CC(C)N=C(N)/N=C(\N)/NC1=CC=C(C=C1)Cl

Synonyms

  • Chloroguanide
  • Chlorguanide
  • Bigumal
  • Chlorguanid
  • Paludrin
  • Proguanilum
  • 1-(p-Chlorophenyl)-5-isopropylbiguanide
  • Proguanile
  • N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide
  • Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-
  • N-(4-chlorophenyl)-N'-(propan-2-yl)imidodicarbonimidic diamide
  • bigumalum (for the hydrochloride)
  • (1E)-1-(amino-(4-chloroanilino)methylidene)-2-propan-2-ylguanidine
  • N1-p-Chlorophenyl-N5-isopropylbiguanide
  • N1-(4-Chlorophenyl)-N5-isopropylbiguanide
  • Proguanil (INN)
  • BIGUANIDE, 1-(p-CHLOROPHENYL)-5-ISOPROPYL-
  • N-(4-chlorophenyl)-N'-(propan-2-yl)triimidodicarbonic diamide
  • N-(4-Chlorophenyl)-N'-(1-methylethyl)imidodicarbonimidic diamide
  • (hydrochloride)
  • Tirian (hydrochloride)
  • Palusil (hydrochloride)
  • Diguanyl (hydrochloride)
  • Drinupal (hydrochloride)
  • Paludrine (hydrochloride)
Show all 29 synonyms
  • M-4888 (hydrochloride)
  • SN-12837 (hydrochloride)
  • XEW
  • Proguanil (Standard)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
253.74 g/molcalc.
Exact mass
253.1094 Dacalc.
LogP (octanol/water)
1.79calc.
Topological polar surface area
88.79 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
2calc.
Heavy atoms
17calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.27calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Proguanil suppliers

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Proguanil price

Indicative price range per kg from live supplier offers

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Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antimalarials
  • Antimetabolites

Roles

  • antifolate
  • antiinfective agent
  • antimalarial
  • antimetabolite
  • antimicrobial agent
  • antimicrobial drug
  • antiparasitic agent
  • antiplasmodial drug
  • antiprotozoal drug
  • enzyme inhibitor
  • pharmaceutical

Pharmacology

Proguanil is an Antimalarial. The mechanism of action of proguanil is as a Dihydrofolate Reductase Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Proguanil is traded under.

HS 2925.29Indicative HS code

Imines and their derivatives, salts thereof, other

World exports in 2024
$1.8B
+12.4% vs 2023, imports $1.84B
2019 to 2024
Top exporters
  1. China35.9%
  2. France * partner reported15.5%
  3. Germany9.1%
Top importers
  1. United States13.3%
  2. China13.0%
  3. Brazil9.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Proguanil is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Proguanil, based on the data on this page

What is Proguanil?

Proguanil is a biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P.

What is the CAS number of Proguanil?

The CAS registry number of Proguanil is 500-92-5.

What is the molecular formula and weight of Proguanil?

The molecular formula of Proguanil is C11H16ClN5 and its molar mass is 253.74 g/mol.

What is Proguanil used for?

Known uses and roles of Proguanil include antifolate, antiinfective agent, antimalarial, antimetabolite, antimicrobial agent and 8 more.

Is Proguanil hazardous?

No GHS hazard classification for Proguanil is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Proguanil?

Proguanil is usually classified under HS code 292529 (Imines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Proguanil?

Post a free request on CompoundList and suppliers of Proguanil will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Proguanil?

Suppliers quote Proguanil on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Proguanil

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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