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Hormones and steroids

Propylthiouracil

Also known as 6-Propyl-2-thiouracil, Propacil, Prothyran

CAS 51-52-5Formula C7H10N2OSMolar mass 170.24 g/molEC 200-103-2
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 106 suppliers listed Drug substance
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Propylthiouracil chemical structure, C7H10N2OS, CAS 51-52-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White crystalline powder of starch-like appearance to eye and to touch
Melting point
219 to 221
Solubility
1 part dissolves in about 900 parts water at 20 °C, in 100 parts boiling water, in 60 pa…
HS code
293359
Category
Hormones and steroids
Illustrative photo, off-white crystalline powder in fibre drums in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Propylthiouracil?

Plain description, key identifiers and synonyms

6-propyl-2-thiouracil is a pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group. It has a role as an antioxidant, an antimetabolite, a hormone antagonist, an antithyroid drug, a carcinogenic agent, an EC 1.14.13.39 (nitric oxide synthase) inhibitor and an antidote to paracetamol poisoning. It is functionally related to a uracil.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6-propyl-2-sulfanylidene-1H-pyrimidin-4-one
CAS number
51-52-5 CAS number cross-checkedOther or deprecated CAS: 500-50-5
EC number
200-103-2
Molecular formula
C7H10N2OS
UNII
721M9407IY
MDL number
MFCD00006041, MFCD00052385
InChIKey
KNAHARQHSZJURB-UHFFFAOYSA-N
InChI
InChI=1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)
SMILES (canonical and isomeric)
CCCC1=CC(=O)NC(=S)N1

Synonyms

  • 6-Propyl-2-thiouracil
  • Propacil
  • Prothyran
  • Procasil
  • Propycil
  • Prothiurone
  • Thiuragyl
  • Prothiucil
  • Protiural
  • Prothycil
  • Propyl-Thiorist
  • Propyl-Thyracil
  • 6-Propylthiouracil
  • Thyreostat II
  • 6-propyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
  • Propylthiorit
  • Propythiouracil
  • Propilthiouracil
  • Propyl-Thiorit
  • Propylthiouracile
  • 6-Thio-4-propyluracil
  • Propiltiouracilo
  • 4-Propyl-2-thiouracil
  • Propylthiouracilum
  • 2-Mercapto-6-propyl-4-pyrimidone
Show all 38 synonyms
  • Propiltiouracile
  • 2-Mercapto-6-propylpyrimid-4-one
  • 2-Thio-6-propyl-1,3-pyrimidin-4-one
  • 2-Thio-4-oxo-6-propyl-1,3-pyrimidine
  • 6-propyl-2-sulfanylidene-1H-pyrimidin-4-one
  • 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone
  • 4-Hydroxy-2-mercapto-6-propylpyrimidine
  • Propyl thiouracil
  • 2-Mercapto-4-hydroxy-6-n-propylpyrimidine
  • 6-Propyl-2-thio-2,4(1H,3H)pyrimidinedione
  • 4(1H)-Pyrimidinone, 2,3-dihydro-6-propyl-2-thioxo-
  • 6-propyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one
  • 6 Propyl 2 Thiouracil

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White crystalline powder of starch-like appearance to eye and to touchexp.
Taste
Bitterexp.
Melting point
219 to 221exp.
Solubility
1 part dissolves in about 900 parts water at 20 °C, in 100 parts boiling water, in 60 parts ethyl alc, in 60 parts acetone, practically insol in ether, chloroform, benzene, freely sol in aq soln of ammonia and alkali hydroxidesexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
170.24 g/molcalc.
Exact mass
170.0514 Dacalc.
LogP (octanol/water)
1.38calc.
Topological polar surface area
48.65 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
2calc.
Heavy atoms
11calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.43calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cc[nH]c(=S)[nH]1

O=c1cc[nH]c(=S)[nH]1

1 ring, 8 atoms, the Thiouracil ring system.

260 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H351Suspected of causing cancer.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Propylthiouracil suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 106 suppliers
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Where suppliers are based

106 suppliers in 19 countries

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Propylthiouracil price

Indicative price range per kg from live supplier offers

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Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Medication, thyroid inhibitor.

Veterinary medication:.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Antimetabolites
  • Antithyroid Agents

Roles

  • aetiopathogenetic role
  • antagonist
  • antidote
  • antidote to paracetamol poisoning
  • antimetabolite
  • antioxidant
  • antithyroid drug
  • carcinogenic agent
  • enzyme inhibitor
  • hormone antagonist
  • hormone receptor modulator
  • pharmaceutical
  • protective agent
  • receptor modulator

Pharmacology

Propylthiouracil is a Thyroid Hormone Synthesis Inhibitor. The mechanism of action of propylthiouracil is as a Thyroid Hormone Synthesis Inhibitor.

How it is made

Prepd by condensation of ethyl beta-oxocaproate with thiourea.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Propylthiouracil is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Propylthiouracil is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Propylthiouracil, based on the data on this page

What is Propylthiouracil?

6-propyl-2-thiouracil is a pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group.

What is the CAS number of Propylthiouracil?

The CAS registry number of Propylthiouracil is 51-52-5. Other or deprecated CAS numbers: 500-50-5.

What is the molecular formula and weight of Propylthiouracil?

The molecular formula of Propylthiouracil is C7H10N2OS and its molar mass is 170.24 g/mol.

What is Propylthiouracil used for?

Medication, thyroid inhibitor. Veterinary medication:. Use classes: Pharmaceuticals.

Is Propylthiouracil hazardous?

Propylthiouracil carries the GHS signal word "Warning". Main hazards: harmful if swallowed, suspected of causing cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Propylthiouracil?

Propylthiouracil is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Propylthiouracil?

CompoundList lists 106 suppliers of Propylthiouracil in China, United States, Germany, United Kingdom and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Propylthiouracil in India?

3 suppliers in India list Propylthiouracil on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Propylthiouracil?

Suppliers quote Propylthiouracil on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Propylthiouracil

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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