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Cosmetic antioxidants

Pterostilbene

Also known as trans-pterostilbene, 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol, pterostilbene, (E)-

CAS 537-42-8Formula C16H16O3Molar mass 256.30 g/molEC 611-041-4
GHS signal word: Danger. Pictograms: Corrosive, Hazardous to the environment 77 suppliers listed
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Pterostilbene chemical structure, C16H16O3, CAS 537-42-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
537-42-8
Formula
C16H16O3
Molar mass
256.30 g/mol
EC number
611-041-4
HS code
290950
Category
Cosmetic antioxidants

What is Pterostilbene?

Plain description, key identifiers and synonyms

Pterostilbene is a stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'. It has a role as an antioxidant, a neurotransmitter, a hypoglycemic agent, an antineoplastic agent, a radical scavenger, a neuroprotective agent, an anti-inflammatory agent, an apoptosis inducer and a plant metabolite. It is a stilbenol, a diether and a member of methoxybenzenes. It derives from a hydride of a trans-stilbene.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol
CAS number
537-42-8 CAS number cross-checkedOther or deprecated CAS: 1318852-41-3, 18259-15-9
EC number
611-041-4
Molecular formula
C16H16O3
UNII
26R60S6A5I
MDL number
MFCD00238710
INCI name
RESVERATROL DIMETHYL ETHER
InChIKey
VLEUZFDZJKSGMX-ONEGZZNKSA-N
InChI
InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
Canonical SMILES
COc1cc(C=Cc2ccc(O)cc2)cc(OC)c1
Isomeric SMILES
COC1=CC(=CC(=C1)/C=C/C2=CC=C(C=C2)O)OC

Synonyms

  • trans-pterostilbene
  • 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol
  • pterostilbene, (E)-
  • 3',5'-Dimethoxy-4-stilbenol
  • 3,5-Dimethoxy-4'-hydroxy-trans-stilbene
  • Phenol, 4-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-
  • 3',5'-dimethoxy-resveratrol
  • trans-3,5-dimethoxy-4'-hydroxystilbene
  • 3,5-Dimethoxy-4'-hydroxystilbene
  • 4-((E)-2-(3,5-dimethoxyphenyl)ethenyl)phenol
  • phenol, 4-((1E)-2-(3,5-dimethoxyphenyl)ethenyl)-
  • eh-301 Component pterostilbene
  • Phenol, 4-(2-(3,5-dimethoxyphenyl)ethenyl)-, (E)-
  • 3',5'-dimethoxy-4E-stilbenol
  • 3',5'-dimethoxy-4trans-stilbenol
  • 4trans-(2-(3,5-dimethoxyphenyl)ethenyl)phenol
  • Trans-3,5-dimethoxy-4-hydroxystilbene
  • 4-(3,5-Dimethoxystyryl)phenol
  • (E)-4-(3,5-dimethoxystyryl)phenol
  • 4-[(E)-2-(3,5-dimethoxyphenyl)vinyl]phenol
  • 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol
  • phenol, 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]-
  • (Z)-Pterostilbene
  • 4-((1E)-2-(3,5-Dimethoxyphenyl)ethenyl)phenol
  • pterostilben
Show all 32 synonyms
  • pTeroPure
  • Tero-STILL-bean
  • 4-Stilbenol, 3',5'-dimethoxy-, (E)-
  • Pterostilbene (Standard)
  • ACon1_000305
  • Pterostilbene - Bio-X trade mark
  • (E)-3',5'-dimethoxy-4-stilbenol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
256.30 g/molcalc.
Exact mass
256.1099 Dacalc.
LogP (octanol/water)
3.58calc.
Topological polar surface area
38.69 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
19calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.13calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C(=Cc1ccccc1)c1ccccc1

C(=Cc1ccccc1)c1ccccc1

2 rings, 14 atoms, the Stilbene ring system.

2,005 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H318Causes serious eye damage.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (7)
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Pterostilbene suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 77 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

77 suppliers in 12 countries

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Pterostilbene price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name RESVERATROL DIMETHYL ETHER(antioxidant, skin conditioning)

Roles

  • anti-inflammatory agent
  • antineoplastic agent
  • antioxidant
  • apoptosis inducer
  • eukaryotic metabolite
  • hypoglycemic agent
  • metabolite
  • molecular messenger
  • neuroprotective agent
  • neurotransmitter
  • pharmaceutical
  • plant metabolite
  • protective agent
  • radical scavenger
  • renoprotective agent

Functional uses

  • Antioxidant
  • Softener and conditioner

Cosmetic functions

  • Antioxidant
  • Skin conditioning

Pharmacology

Pterostilbene is a naturally-derived stilbenoid structurally related to resveratrol, with potential antioxidant, anti-inflammatory, pro-apoptotic, antineoplastic and cytoprotective activities. Upon administration, pterostilbene exerts its anti-oxidant activity by scavenging reactive oxygen species (ROS), thereby preventing oxidative stress and ROS-induced cell damage. It may also activate the nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated pathway and increase the expression of various antioxidant enzymes, such as superoxide dismutase (SOD).

Read more

In addition, pterostilbene is able to inhibit inflammation by reducing the expression of various inflammatory mediators, such as interleukin (IL) 1beta, tumor necrosis factor alpha (TNF-a), inducible nitric oxide synthase (iNOS), cyclooxygenases (COX), and nuclear factor kappa B (NF-kB). It also inhibits or prevents the activation of many signaling pathways involved in carcinogenesis, and increases expression of various tumor suppressor genes while decreasing expression of certain tumor promoting genes. It also directly induces apoptosis in tumor cells.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Pterostilbene is traded under.

HS 2909.50Indicative HS code

Ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or…

World exports in 2024
$284M
+11.9% vs 2023, imports $291M
2019 to 2024
Top exporters
  1. India * partner reported32.9%
  2. Indonesia17.7%
  3. France * partner reported11.2%
Top importers
  1. China20.7%
  2. United States12.0%
  3. Brazil6.8%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Pterostilbene is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Pterostilbene, based on the data on this page

What is Pterostilbene?

Pterostilbene is a stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'.

What is the CAS number of Pterostilbene?

The CAS registry number of Pterostilbene is 537-42-8. Other or deprecated CAS numbers: 1318852-41-3, 18259-15-9.

What is the molecular formula and weight of Pterostilbene?

The molecular formula of Pterostilbene is C16H16O3 and its molar mass is 256.30 g/mol.

What is Pterostilbene used for?

Known uses and roles of Pterostilbene include antioxidants in cosmetics and personal care, skin conditioning agents in cosmetics and personal care, anti-inflammatory agent, antineoplastic agent, antioxidant and 14 more.

Is Pterostilbene hazardous?

Pterostilbene carries the GHS signal word "Danger". Main hazards: causes serious eye damage, toxic to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Pterostilbene?

Pterostilbene is usually classified under HS code 290950 (Ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Pterostilbene?

CompoundList lists 77 suppliers of Pterostilbene in China, United States, India, Germany and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Pterostilbene in India?

5 suppliers in India list Pterostilbene on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Pterostilbene?

Suppliers quote Pterostilbene on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Pterostilbene

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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