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Antibiotics and anti-infectives

Pyrazinamide

Also known as pyrazinecarboxamide, pyrazine-2-carboxamide, Aldinamide

CAS 98-96-4Formula C5H5N3OMolar mass 123.12 g/molEC 202-717-6
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant 131 suppliers listed Drug substance
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Pyrazinamide chemical structure, C5H5N3O, CAS 98-96-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
192 °C
Boiling point
SUB
Solubility
In water, 15 mg/ml @ 25 °C
HS code
293399
Category
Antibiotics and anti-infectives
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Pyrazinamide?

Plain description, key identifiers and synonyms

Pyrazinecarboxamide is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis. It has a role as an antitubercular agent and a prodrug. It is a monocarboxylic acid amide, a member of pyrazines and a N-acylammonia.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
pyrazine-2-carboxamide
CAS number
98-96-4 CAS number cross-checked
EC number
202-717-6
Molecular formula
C5H5N3O
UNII
2KNI5N06TI
MDL number
MFCD00006132
InChIKey
IPEHBUMCGVEMRF-UHFFFAOYSA-N
InChI
InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
SMILES (canonical and isomeric)
C1=CN=C(C=N1)C(=O)N

Synonyms

  • pyrazinecarboxamide
  • pyrazine-2-carboxamide
  • Aldinamide
  • Zinamide
  • pyrazinoic acid amide
  • Aldinamid
  • Farmizina
  • Pirazimida
  • Pirazinamid
  • Unipyranamide
  • Eprazin
  • Novamid
  • Tebrazid
  • Pyrafat
  • pyrazine carboxylamide
  • Pyrazineamide
  • Isopas
  • 2-Carbamylpyrazine
  • Pyrazinecarboxylic acid amide
  • Pirazinamida
  • Pyrazinamidum
  • Pyrazide
  • Rozide
  • Pirazinamide
  • Pyrazine carboxamide
Show all 37 synonyms
  • pyramizade
  • MK 56
  • pyrazine-2-carboximidic acid
  • 5-25-04-00178 (Beilstein Handbook Reference)
  • alpha-pyrazinamide
  • pyrazinamide tablet
  • Pirilene
  • 2-Pyrazinecarboxamide
  • PZA
  • Tisamid
  • Piraldina
  • Pyrazinamide (Pyrazinoic acid amide)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Melting point
192 °Cexp.
Boiling point
SUBexp.
Solubility
In water, 15 mg/ml @ 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
123.12 g/molcalc.
Exact mass
123.0433 Dacalc.
LogP (octanol/water)
-0.42calc.
Topological polar surface area
68.87 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
9calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cnccn1

c1cnccn1

1 ring, 6 atoms, the Pyrazine ring system.

6,118 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H310Fatal in contact with skin.
  • H315Causes skin irritation.
  • H330Fatal if inhaled.
Precautionary statements (18)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Pyrazinamide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 131 suppliers
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Where suppliers are based

131 suppliers in 23 countries

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Pyrazinamide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Antibacterial (tuberculostatic).

Pyrazinamide is a bactericidal antitubercular agent that is used in combination with other antitubercular agents, especially in developing nations. ... In the US, pyrazinamide is generally reserved for combination use in patients infected with drug-resistant strains.

Pharmacological actions

  • Antitubercular Agents

Roles

  • anti-HIV agent
  • antibacterial agent
  • antibacterial drug
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • antimycobacterial drug
  • antitubercular agent
  • antiviral agent
  • pharmaceutical
  • pro-agent
  • prodrug

Pharmacology

Pyrazinamide is an Antimycobacterial.

How it is made

Quinoxaline + ammonia (side-chain oxidation/decarboxylation/amide formation)

Prepd by ammonolysis of methyl pyrazinoate (from quinoxaline): Dalmer, Walter, Ger. Pat. 632,257 (1936 to E. Merck), Brit. Pat. 451,304, U.S. pat. 2,149,279 (1939 to Merck & Co.), Hall, Spoerri, J. Am. Chem. Soc. 62, 664 (1940), Williams, Kushner, U.S. pat. 2,677,641 (1954 to Am Cyanamid), by thermal decarboxylation of pyrazine-2-carboxamide-3-carboxylic acid: Webb, Arlt, U.S. pat. 2,780,624 (1957 to Am. Cyanamid).

Prepn: O. Dalmer, E. Walter, DE 632257 (1936 to E. Merck), eidem, US 2149279 (1939 to Merck & Co.)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Inactive in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Pyrazinamide is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Pyrazinamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Pyrazinamide, based on the data on this page

What is Pyrazinamide?

Pyrazinecarboxamide is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.

What is the CAS number of Pyrazinamide?

The CAS registry number of Pyrazinamide is 98-96-4.

What is the molecular formula and weight of Pyrazinamide?

The molecular formula of Pyrazinamide is C5H5N3O and its molar mass is 123.12 g/mol.

What is Pyrazinamide used for?

Antibacterial (tuberculostatic). Pyrazinamide is a bactericidal antitubercular agent that is used in combination with other antitubercular agents, especially in developing nations. ... In the US, pyrazinamide is generally reserved for combination use in patients infected with drug-resistant strains.

Is Pyrazinamide hazardous?

Pyrazinamide carries the GHS signal word "Danger". Main hazards: fatal in contact with skin, causes skin irritation, fatal if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Pyrazinamide?

Pyrazinamide is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Pyrazinamide?

CompoundList lists 131 suppliers of Pyrazinamide in United States, China, India, United Kingdom and 19 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Pyrazinamide in India?

19 suppliers in India list Pyrazinamide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Pyrazinamide?

Suppliers quote Pyrazinamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Pyrazinamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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