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Antibiotics and anti-infectives

Pyronaridine

Also known as Malaridine, Benzonaphthyridine 7351, pironaridina

CAS 74847-35-1Formula C29H32ClN5O2Molar mass 518.06 g/mol
6 suppliers listed
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Pyronaridine chemical structure, C29H32ClN5O2, CAS 74847-35-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
74847-35-1
Formula
C29H32ClN5O2
Molar mass
518.06 g/mol
HS code
293399
Category
Antibiotics and anti-infectives

What is Pyronaridine?

Plain description, key identifiers and synonyms

Pyronaridine is an aminoquinoline.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol
CAS number
74847-35-1 CAS number cross-checked
Molecular formula
C29H32ClN5O2
UNII
TD3P7Q3SG6
MDL number
MFCD01748123
InChIKey
DJUFPMUQJKWIJB-UHFFFAOYSA-N
InChI
InChI=1S/C29H32ClN5O2/c1-37-26-9-8-24-28(33-26)27(23-7-6-21(30)16-25(23)32-24)31-22-14-19(17-34-10-2-3-11-34)29(36)20(15-22)18-35-12-4-5-13-35/h6-9,14-16,36H,2-5,10-13,17-18H2,1H3,(H,31,32)
SMILES (canonical and isomeric)
COC1=NC2=C(C3=C(C=C(C=C3)Cl)N=C2C=C1)NC4=CC(=C(C(=C4)CN5CCCC5)O)CN6CCCC6

Synonyms

  • Malaridine
  • Benzonaphthyridine 7351
  • pironaridina
  • 2-Methoxy-7-chloro-10-(3',5'-bis(pyrrolin-1-ylmethyl)-4'-hydroxyphenylamino)benzo(b)-1,5-naphthyridine
  • 4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol
  • 4-((7-Chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyrrolidinylmethyl)phenol
  • 4-((7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino)-2,6-bis(pyrrolidin-1-ylmethyl)phenol
  • 4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol
  • 4-((7-Chloro-2-methoxybenzo(b)(1,5)naphthyridin-10-yl)amino)-2,6-bis((pyrrolidin-1-yl)methyl)phenol
  • pyronaridinum
  • 4-((7-chloro-2-methoxybenzo(b)(1,5)naphthyridin-10-yl)amino)-2,6-bis(pyrrolidin-1-ylmethyl)phenol
  • 4-[(7-Chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis[(pyrrolidin-1-yl)methyl]phenol
  • 4-((7-chloro-2-methoxybenzo(b)1,5-naphthyridin-10-yl)amino)-2,6-bis((pyrrolidin-1-yl)methyl)phenol
  • 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one
  • 4-[(7-chloro-2-methoxy-benzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol
  • Phenol, 4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyrrolidinylmethyl)-
  • C29H32ClN5O2
  • Pyronaridine?
  • malaridine phosphate
  • Phenol, 4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-
  • 4-(2-Methoxy-6-chloro-1,10-diazaanthracene-9-ylamino)-2,6-bis(pyrrolizinomethyl)phenol
  • 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-...
  • 2-Methoxy-7-chloro-10-(3'5'-bis(pyrrolin-1-ylmethyl)-4'-hydroxyphenylamino)benzo(b)-15-naphthyridine
  • 4-({7-chloro-2-methoxy-1H,5H-benzo[b]1,5-naphthyridin-10-yl}imino)-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one
  • 4-(7-chloro-2-Methoxybenzo[b][1,5]naphthyridin-10-ylaMino)-2,6-bis(pyrrolidin-1-ylMethyl)phenol
Show all 30 synonyms
  • 4-[(7-chloranyl-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one, phosphoric acid
  • 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(1-pyrrolidinylmethyl)-1-cyclohexa-2,5-dienone, phosphoric acid
  • 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one, phosphoric acid
  • 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidinomethyl)cyclohexa-2,5-dien-1-one, phosphoric acid
  • 4-[(7-Chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
518.06 g/molcalc.
Exact mass
517.2245 Dacalc.
LogP (octanol/water)
6.09calc.
Topological polar surface area
73.75 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
7calc.
Heavy atoms
37calc.
Rings
6calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.38calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(Nc3cc(CN4CCCC4)cc(CN4CCCC4)c3)c3ncccc3nc2c1

c1ccc2c(Nc3cc(CN4CCCC4)cc(CN4CCCC4)c3)c3ncccc3nc2c1

6 rings, 33 atoms.

7 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Pyronaridine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 6 suppliers
6 of 6 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

6 suppliers in 4 countries

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Pyronaridine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antimalarials

Roles

  • antiinfective agent
  • antimalarial
  • antimicrobial agent
  • antimicrobial drug
  • antiparasitic agent
  • antiplasmodial drug
  • antiprotozoal drug
  • antiviral agent
  • ophthalmology drug
  • pharmaceutical

Pharmacology

Pyronaridine is a benzonaphthyridine derivative, with antimalarial and potential antiviral activities. Upon administration, pyronaridine inhibits the formation of beta-hematin, which results in the accumulation of toxic heme within the parasite. In addition, pyronaridine inhibits glutathione-dependent degradation of hematin. This promotes hematin-induced lysis of red blood cells (RBCs), resulting in parasite death. Pyronaridine also exhibits antiviral activity against some viruses in vitro, including Ebola (EBOV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) viruses.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Pyronaridine is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Pyronaridine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Pyronaridine, based on the data on this page

What is Pyronaridine?

Pyronaridine is an aminoquinoline.

What is the CAS number of Pyronaridine?

The CAS registry number of Pyronaridine is 74847-35-1.

What is the molecular formula and weight of Pyronaridine?

The molecular formula of Pyronaridine is C29H32ClN5O2 and its molar mass is 518.06 g/mol.

What is Pyronaridine used for?

Known uses and roles of Pyronaridine include antiinfective agent, antimalarial, antimicrobial agent, antimicrobial drug, antiparasitic agent and 6 more.

Is Pyronaridine hazardous?

No GHS hazard classification for Pyronaridine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Pyronaridine?

Pyronaridine is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Pyronaridine?

CompoundList lists 6 suppliers of Pyronaridine in China, Hong Kong, Ukraine and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Pyronaridine?

Suppliers quote Pyronaridine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Pyronaridine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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