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Pharmaceuticals and APIs

Regorafenib

Also known as BAY 73-4506, Stivarga, Regorafenibum

CAS 755037-03-7Formula C21H15ClF4N4O3Molar mass 482.82 g/molEC 815-051-1
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Regorafenib chemical structure, C21H15ClF4N4O3, CAS 755037-03-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
755037-03-7
Formula
C21H15ClF4N4O3
Molar mass
482.82 g/mol
EC number
815-051-1
HS code
293339
Category
Pharmaceuticals and APIs

What is Regorafenib?

Plain description, key identifiers and synonyms

Regorafenib is a pyridinecarboxamide obtained by condensation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]pyridine-2-carboxylic acid with methylamine. Used for for the treatment of metastatic colorectal cancer in patients who have previously received chemotherapy, anti-EGFR or anti-VEGF therapy. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor and a hepatotoxic agent. It is a member of phenylureas, a pyridinecarboxamide, an aromatic ether, a member of monochlorobenzenes, a member of (trifluoromethyl)benzenes and a member of monofluorobenzenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
CAS number
755037-03-7 CAS number cross-checked
EC number
815-051-1
Molecular formula
C21H15ClF4N4O3
UNII
24T2A1DOYB
MDL number
MFCD16038047
InChIKey
FNHKPVJBJVTLMP-UHFFFAOYSA-N
InChI
InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
SMILES (canonical and isomeric)
CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F

Synonyms

  • BAY 73-4506
  • Stivarga
  • Regorafenibum
  • Regorafenib anhydrous
  • 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
  • 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
  • BAY-734506 monohydrate
  • BAY 73-4506 monohydrate
  • Bay-73-4506 monohydrate
  • 4-(4-(((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)amino)-3-fluorophenoxy)-n-methylpyridine-2-carboxamide
  • 4-(4-(((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl}amino)-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
  • 4-(4-((4-chloro-3-(trifluoromethyl)phenyl)carbamoylamino)-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
  • 2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)-3-fluorophenoxy)-N-methyl-, hydrate (1:1)
  • 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide
  • Regorafenib (BAY 73-4506)
  • C21H15ClF4N4O3
  • Regorafenib,BAY 73-4506
  • 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide
  • 2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
  • Stivarga (TN)
  • 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluoro-phenoxy]-N-methyl-pyridine-2-carboxamide
  • 4-[4-({[4-Chloro-3-(trifluoromethy)phenyl]carbamoyl}amino)-3-fluorophenoxy]-1-methylpyridine-2-carboxamide
  • Regorafenib (Standard)
  • 2-Pyridinecarboxamide,4
  • Regorafenib (USAN/INN)
Show all 29 synonyms
  • BAY73-4506 hydrochloride
  • Regorafenib crystalline form I
  • 755037-03-7 , Regorafenib
  • Sdccgsbi-0654355.p001

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
482.82 g/molcalc.
Exact mass
482.0769 Dacalc.
LogP (octanol/water)
5.69calc.
Topological polar surface area
92.35 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
5calc.
Heavy atoms
33calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1ccccc1)Nc1ccc(Oc2ccncc2)cc1

O=C(Nc1ccccc1)Nc1ccc(Oc2ccncc2)cc1

3 rings, 23 atoms.

51 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Regorafenib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 72 suppliers
30 of 30 offers

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Where suppliers are based

72 suppliers in 8 countries

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Regorafenib price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Roles

  • aetiopathogenetic role
  • antineoplastic agent
  • enzyme inhibitor
  • hepatotoxic agent
  • ophthalmology drug
  • pharmaceutical
  • protein kinase inhibitor
  • tyrosine kinase inhibitor

Pharmacology

Regorafenib anhydrous is a Kinase Inhibitor. The mechanism of action of regorafenib anhydrous is as a Kinase Inhibitor, and Cytochrome P450 2C9 Inhibitor, and Breast Cancer Resistance Protein Inhibitor, and UGT1A9 Inhibitor, and UGT1A1 Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Regorafenib is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Regorafenib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Regorafenib, based on the data on this page

What is Regorafenib?

Regorafenib is a pyridinecarboxamide obtained by condensation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]pyridine-2-carboxylic acid with methylamine.

What is the CAS number of Regorafenib?

The CAS registry number of Regorafenib is 755037-03-7.

What is the molecular formula and weight of Regorafenib?

The molecular formula of Regorafenib is C21H15ClF4N4O3 and its molar mass is 482.82 g/mol.

What is Regorafenib used for?

Known uses and roles of Regorafenib include aetiopathogenetic role, antineoplastic agent, enzyme inhibitor, hepatotoxic agent, ophthalmology drug and 3 more.

Is Regorafenib hazardous?

No GHS hazard classification for Regorafenib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Regorafenib?

Regorafenib is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Regorafenib?

CompoundList lists 72 suppliers of Regorafenib in China, United States, Germany, India and 4 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Regorafenib in India?

2 suppliers in India list Regorafenib on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Regorafenib?

Suppliers quote Regorafenib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Regorafenib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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